Distribution of genetic polymorphisms associated with hepatitis C virus (HCV) antiviral response in a multiethnic and admixed population
The prevalence of genetic polymorphisms identified as predictors of therapeutic-induced hepatitis C virus (HCV) clearance differs among ethnic groups. However, there is a paucity of information about their prevalence in South American populations, whose genetic background is highly admixed. Hence, s...
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| Veröffentlicht in: | The pharmacogenomics journal 2014-12, Vol.14 (6), p.549-554 |
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| creator | Trinks, J Hulaniuk, M L Caputo, M Pratx, L Burgos Ré, V Fortuny, L Pontoriero, A Frías, A Torres, O Nuñez, F Gadano, A Corach, D Flichman, D |
| description | The prevalence of genetic polymorphisms identified as predictors of therapeutic-induced hepatitis C virus (HCV) clearance differs among ethnic groups. However, there is a paucity of information about their prevalence in South American populations, whose genetic background is highly admixed. Hence, single-nucleotide polymorphisms rs12979860, rs1127354 and rs7270101 were characterized in 1350 healthy individuals, and ethnicity was assessed in 259 randomly selected samples. The frequency of rs12979860CC, associated to HCV treatment response, and rs1127354nonCC, related to protection against hemolytic anemia, were significantly higher among individuals with maternal and paternal Non-native American haplogroups (64.5% and 24.2%), intermediate among admixed samples (44.1% and 20.4%) and the lowest for individuals with Native American ancestry (30.4% and 6.5%). This is the first systematic study focused on analyzing HCV predictors of antiviral response and ethnicity in South American populations. The characterization of these variants is critical to evaluate the risk–benefit of antiviral treatment according to the patient ancestry in admixed populations. |
| doi_str_mv | 10.1038/tpj.2014.20 |
| format | Article |
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However, there is a paucity of information about their prevalence in South American populations, whose genetic background is highly admixed. Hence, single-nucleotide polymorphisms rs12979860, rs1127354 and rs7270101 were characterized in 1350 healthy individuals, and ethnicity was assessed in 259 randomly selected samples. The frequency of rs12979860CC, associated to HCV treatment response, and rs1127354nonCC, related to protection against hemolytic anemia, were significantly higher among individuals with maternal and paternal Non-native American haplogroups (64.5% and 24.2%), intermediate among admixed samples (44.1% and 20.4%) and the lowest for individuals with Native American ancestry (30.4% and 6.5%). This is the first systematic study focused on analyzing HCV predictors of antiviral response and ethnicity in South American populations. The characterization of these variants is critical to evaluate the risk–benefit of antiviral treatment according to the patient ancestry in admixed populations.</description><identifier>ISSN: 1470-269X</identifier><identifier>EISSN: 1473-1150</identifier><identifier>DOI: 10.1038/tpj.2014.20</identifier><identifier>PMID: 24841973</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/457/649 ; 692/699/255/234/2513/1551 ; 692/700/565/1436/434 ; Antiviral Agents - pharmacology ; Antiviral Agents - therapeutic use ; Antiviral drugs ; Biomedical and Life Sciences ; Biomedicine ; Drug metabolism ; Drug therapy ; Ethnic Groups - genetics ; Ethnicity ; Gene Expression ; Gene polymorphism ; Genetic aspects ; Genetic polymorphisms ; Genotype ; Hemolytic anemia ; Hepacivirus - drug effects ; Hepatitis C ; Hepatitis C virus ; Hepatitis C, Chronic - drug therapy ; Hepatitis C, Chronic - genetics ; Hepatitis C, Chronic - virology ; Human Genetics ; Humans ; Identification and classification ; Minority & ethnic groups ; Oncology ; original-article ; Pharmacotherapy ; Polymorphism, Single Nucleotide - genetics ; Population genetics ; Psychopharmacology ; Risk Assessment ; Single-nucleotide polymorphism ; South America</subject><ispartof>The pharmacogenomics journal, 2014-12, Vol.14 (6), p.549-554</ispartof><rights>Macmillan Publishers Limited 2014</rights><rights>COPYRIGHT 2014 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2014</rights><rights>Macmillan Publishers Limited 2014.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-f1b99e3a539121cc40031863b6eebda6a255bd70f1a647dfae7465a114e35cd33</citedby><cites>FETCH-LOGICAL-c552t-f1b99e3a539121cc40031863b6eebda6a255bd70f1a647dfae7465a114e35cd33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24841973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trinks, J</creatorcontrib><creatorcontrib>Hulaniuk, M L</creatorcontrib><creatorcontrib>Caputo, M</creatorcontrib><creatorcontrib>Pratx, L Burgos</creatorcontrib><creatorcontrib>Ré, V</creatorcontrib><creatorcontrib>Fortuny, L</creatorcontrib><creatorcontrib>Pontoriero, A</creatorcontrib><creatorcontrib>Frías, A</creatorcontrib><creatorcontrib>Torres, O</creatorcontrib><creatorcontrib>Nuñez, F</creatorcontrib><creatorcontrib>Gadano, A</creatorcontrib><creatorcontrib>Corach, D</creatorcontrib><creatorcontrib>Flichman, D</creatorcontrib><title>Distribution of genetic polymorphisms associated with hepatitis C virus (HCV) antiviral response in a multiethnic and admixed population</title><title>The pharmacogenomics journal</title><addtitle>Pharmacogenomics J</addtitle><addtitle>Pharmacogenomics J</addtitle><description>The prevalence of genetic polymorphisms identified as predictors of therapeutic-induced hepatitis C virus (HCV) clearance differs among ethnic groups. However, there is a paucity of information about their prevalence in South American populations, whose genetic background is highly admixed. Hence, single-nucleotide polymorphisms rs12979860, rs1127354 and rs7270101 were characterized in 1350 healthy individuals, and ethnicity was assessed in 259 randomly selected samples. The frequency of rs12979860CC, associated to HCV treatment response, and rs1127354nonCC, related to protection against hemolytic anemia, were significantly higher among individuals with maternal and paternal Non-native American haplogroups (64.5% and 24.2%), intermediate among admixed samples (44.1% and 20.4%) and the lowest for individuals with Native American ancestry (30.4% and 6.5%). This is the first systematic study focused on analyzing HCV predictors of antiviral response and ethnicity in South American populations. The characterization of these variants is critical to evaluate the risk–benefit of antiviral treatment according to the patient ancestry in admixed populations.</description><subject>631/208/457/649</subject><subject>692/699/255/234/2513/1551</subject><subject>692/700/565/1436/434</subject><subject>Antiviral Agents - pharmacology</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Antiviral drugs</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Drug metabolism</subject><subject>Drug therapy</subject><subject>Ethnic Groups - genetics</subject><subject>Ethnicity</subject><subject>Gene Expression</subject><subject>Gene polymorphism</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genotype</subject><subject>Hemolytic anemia</subject><subject>Hepacivirus - drug effects</subject><subject>Hepatitis C</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic - drug therapy</subject><subject>Hepatitis C, Chronic - genetics</subject><subject>Hepatitis C, Chronic - virology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>Minority & ethnic groups</subject><subject>Oncology</subject><subject>original-article</subject><subject>Pharmacotherapy</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Population genetics</subject><subject>Psychopharmacology</subject><subject>Risk Assessment</subject><subject>Single-nucleotide polymorphism</subject><subject>South America</subject><issn>1470-269X</issn><issn>1473-1150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkk1v1DAQhiMEoqVw4o4scSmCLJ74a3Oslo8iVeICiJvlJJNdrxI72E6h_4CfjcMWVFCFkKXx2H7mHY_0FsVjoCugbP0yTftVRYHncKc4Bq5YCSDo3Z85LStZfz4qHsS4pxQkqPX94qjiaw61YsfF91c2pmCbOVnviO_JFh0m25LJD1ejD9POxjESE6NvrUnYka827cgOJ5NsspFsyKUNcySn55tPz4hxyeazGUjAOHkXkVhHDBnnIVlMO5eVjeuI6Ub7LYtNfpoHs_R-WNzrzRDx0fV-Unx88_rD5ry8eP_23ebsomyFqFLZQ1PXyIxgNVTQtpxSBmvJGonYdEaaSoimU7QHI7nqeoOKS2EAODLRdoydFKcH3Sn4LzPGpEcbWxwG49DPUYOUvKJ8zeh_oJWiSkgmMvr0L3Tv5-DyILqSHBRdoH9RWUvUVCm4obU1A2rrep-CaZfW-ozVFSgpFc_U6hYqrw5H23qHvc33fxQ8PxS0wccYsNdTsKMJVxqoXoyks5H0YqQcMv3k-qtzM2L3m_3lnAy8OAAxP7kthhuz3KL3Ay390UI</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Trinks, J</creator><creator>Hulaniuk, M L</creator><creator>Caputo, M</creator><creator>Pratx, L Burgos</creator><creator>Ré, V</creator><creator>Fortuny, L</creator><creator>Pontoriero, A</creator><creator>Frías, A</creator><creator>Torres, O</creator><creator>Nuñez, F</creator><creator>Gadano, A</creator><creator>Corach, D</creator><creator>Flichman, D</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20141201</creationdate><title>Distribution of genetic polymorphisms associated with hepatitis C virus (HCV) antiviral response in a multiethnic and admixed population</title><author>Trinks, J ; Hulaniuk, M L ; Caputo, M ; Pratx, L Burgos ; Ré, V ; Fortuny, L ; Pontoriero, A ; Frías, A ; Torres, O ; Nuñez, F ; Gadano, A ; Corach, D ; Flichman, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-f1b99e3a539121cc40031863b6eebda6a255bd70f1a647dfae7465a114e35cd33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>631/208/457/649</topic><topic>692/699/255/234/2513/1551</topic><topic>692/700/565/1436/434</topic><topic>Antiviral Agents - 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Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The pharmacogenomics journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trinks, J</au><au>Hulaniuk, M L</au><au>Caputo, M</au><au>Pratx, L Burgos</au><au>Ré, V</au><au>Fortuny, L</au><au>Pontoriero, A</au><au>Frías, A</au><au>Torres, O</au><au>Nuñez, F</au><au>Gadano, A</au><au>Corach, D</au><au>Flichman, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of genetic polymorphisms associated with hepatitis C virus (HCV) antiviral response in a multiethnic and admixed population</atitle><jtitle>The pharmacogenomics journal</jtitle><stitle>Pharmacogenomics J</stitle><addtitle>Pharmacogenomics J</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>14</volume><issue>6</issue><spage>549</spage><epage>554</epage><pages>549-554</pages><issn>1470-269X</issn><eissn>1473-1150</eissn><abstract>The prevalence of genetic polymorphisms identified as predictors of therapeutic-induced hepatitis C virus (HCV) clearance differs among ethnic groups. However, there is a paucity of information about their prevalence in South American populations, whose genetic background is highly admixed. Hence, single-nucleotide polymorphisms rs12979860, rs1127354 and rs7270101 were characterized in 1350 healthy individuals, and ethnicity was assessed in 259 randomly selected samples. The frequency of rs12979860CC, associated to HCV treatment response, and rs1127354nonCC, related to protection against hemolytic anemia, were significantly higher among individuals with maternal and paternal Non-native American haplogroups (64.5% and 24.2%), intermediate among admixed samples (44.1% and 20.4%) and the lowest for individuals with Native American ancestry (30.4% and 6.5%). This is the first systematic study focused on analyzing HCV predictors of antiviral response and ethnicity in South American populations. The characterization of these variants is critical to evaluate the risk–benefit of antiviral treatment according to the patient ancestry in admixed populations.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24841973</pmid><doi>10.1038/tpj.2014.20</doi><tpages>6</tpages></addata></record> |
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| subjects | 631/208/457/649 692/699/255/234/2513/1551 692/700/565/1436/434 Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Antiviral drugs Biomedical and Life Sciences Biomedicine Drug metabolism Drug therapy Ethnic Groups - genetics Ethnicity Gene Expression Gene polymorphism Genetic aspects Genetic polymorphisms Genotype Hemolytic anemia Hepacivirus - drug effects Hepatitis C Hepatitis C virus Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - genetics Hepatitis C, Chronic - virology Human Genetics Humans Identification and classification Minority & ethnic groups Oncology original-article Pharmacotherapy Polymorphism, Single Nucleotide - genetics Population genetics Psychopharmacology Risk Assessment Single-nucleotide polymorphism South America |
| title | Distribution of genetic polymorphisms associated with hepatitis C virus (HCV) antiviral response in a multiethnic and admixed population |
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