Protein amino-terminal modifications and proteomic approaches for N-terminal profiling

•N-terminal acetylation, pyroglutamate formation, N-degrons and proteolysis are reviewed.•N-terminomics provide comprehensive profiling of modification at protein N-termini in a proteome-wide manner.•We outline a number of established methodologies for the enrichment of protein N-termini through pos...

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Veröffentlicht in:	Current opinion in chemical biology 2015-02, Vol.24, p.71-79
Hauptverfasser:	Lai, Zon W, Petrera, Agnese, Schilling, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Humans Mass Spectrometry - methods Molecular Sequence Data Protein Processing, Post-Translational Proteins - chemistry Proteome - chemistry Proteomics - methods
Online-Zugang:	Volltext
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