Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer

The maintenance cytosine DNA methyltransferase DNMT1 and de novo methyltransferase DNMT3b cooperate to establish aberrant DNA methylation and chromatin complexes to repress gene transcription during cancer development. The expression of DNMT3b was constitutively increased 5–20-fold in hTERT/CDK4 -im...

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Veröffentlicht in:	Oncogene 2015-01, Vol.34 (5), p.621-630
Hauptverfasser:	Teneng, I, Tellez, C S, Picchi, M A, Klinge, D M, Yingling, C M, Snider, A M, Liu, Y, Belinsky, S A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/2487/2486 631/67/1612/1350 Animals Apoptosis Basic Helix-Loop-Helix Transcription Factors - biosynthesis Carcinogens Carcinogens - toxicity Cell Biology Chromatin Chromatin - genetics Cyclin-dependent kinase 4 Cytosine Deoxyribonucleic acid Development and progression DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA methylation DNA Methylation - genetics DNA methyltransferase DNA Methyltransferase 3B DNMT1 protein Epigenesis, Genetic - genetics Epigenetic inheritance Epithelial cells Gene Expression Regulation, Neoplastic Gene silencing Genes Genetic aspects Genetic transformation Genomes Human Genetics Humans Internal Medicine Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Medicine Medicine & Public Health Membrane Glycoproteins - biosynthesis Methylation Methyltransferases Mice Nerve Tissue Proteins - biosynthesis Non-small cell lung carcinoma Olig2 protein Oligodendrocyte Transcription Factor 2 Oncology original-article Physiological aspects Polycomb group proteins Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism Protein Transport Receptors, Interleukin-1 - biosynthesis Risk factors Studies Telomerase - metabolism Telomerase reverse transcriptase Tobacco Transcription Tumor cell lines Tumor suppressor genes Xenograft Model Antitumor Assays Xenografts
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