Dual energy X-ray absorptiometry of the knee in spinal cord injury: methodology and correlation with quantitative computed tomography
Study Design: Comparison of diagnostic tests; methodological validation. Objectives: Primary: to investigate the precision and reliability of a knee bone mineral density (BMD) assessment protocol that uses an existing dual energy X-ray absorptiometry (DXA) forearm acquisition algorithm in individual...
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description | Study Design:
Comparison of diagnostic tests; methodological validation.
Objectives:
Primary: to investigate the precision and reliability of a knee bone mineral density (BMD) assessment protocol that uses an existing dual energy X-ray absorptiometry (DXA) forearm acquisition algorithm in individuals with spinal cord injury (SCI). Secondary: to correlate DXA-based knee areal BMD with volumetric BMD assessments derived from quantitative computed tomography (QCT).
Setting:
Academic medical center, Chicago, IL, USA.
Methods:
Participants: a convenience sample of 12 individuals with acute SCI recruited for an observational study of bone loss and 34 individuals with chronic SCI who were screened for a longitudinal study evaluating interventions to increase BMD. Main outcome measures: root-mean-square standard deviation (RMS-SD) and intra/inter-rater reliability of areal BMD acquired at three knee regions using an existing DXA forearm acquisition algorithm; correlation of DXA-based areal BMD with QCT-derived volumetric BMD.
Results:
The RMS-SD of areal BMD at the distal femoral epiphysis, distal femoral metaphysis and proximal tibial epiphysis averaged 0.021, 0.012 and 0.016 g cm
−2
, respectively, in acute SCI and 0.018, 0.02 and 0.016 g cm
−2
in chronic SCI. All estimates of intra/inter-rater reliability exceeded 97% and DXA-based areal BMD was significantly correlated with QCT-derived volumetric BMD at all knee regions analyzed.
Conclusions:
Existing DXA forearm acquisition algorithms are sufficiently precise and reliable for short-term assessments of knee BMD in individuals with SCI. Future work is necessary to quantify the reliability of this approach in longitudinal investigations and to determine its ability to predict fractures and recovery potential.
Sponsorship:
This work was funded by the Department of Defense, grant number DOD W81XWH-10-1-0951, with partial support from Merck & Co, Inc. |
doi_str_mv | 10.1038/sc.2014.122 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1664202916</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1622057612</sourcerecordid><originalsourceid>FETCH-LOGICAL-c494t-688fb42e05527037a832845645060bcfa56a2701405070b336090f0d9201c0263</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhi1UREvhxL2y1EslyDL-TNJbtXxKlbiAxC1yEmc328RObacoP4D_3Vm2VAhx4OTxvM-8I81LyCsGKwaieBubFQcmV4zzJ-SEyVxnSnN5hLXQPJOiFMfkeYw7AChZWTwjx1wBF4VmJ-Tnu9kM1DobNgv9ngWzUFNHH6bU-9GmsFDf0bS19MZZS3tH49Q7nGh8aPG7m8NySRHc-tYPHj2Ma_disINBC0d_9GlLb2fjUp-wc2dRHac52ZYmP_pNMNN2eUGedmaI9uXDe0q-fXj_df0pu_7y8fP66jprZClTpouiqyW3oBTPQeSmELyQSksFGuqmM0obFJgEBTnUQmgooYO2xPs0wLU4JRcH3yn429nGVI19bOwwGGf9HCumteTAS_Y_KOegcs04oud_oTs_B7zSL4rhXqEEUq8PVBN8jMF21RT60YSlYlDtg6xiU-2DrDBIpM8ePOd6tO0j-zs5BN4cgIiS29jwx9J_-N0DDUSmYQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1621263353</pqid></control><display><type>article</type><title>Dual energy X-ray absorptiometry of the knee in spinal cord injury: methodology and correlation with quantitative computed tomography</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>McPherson, J G ; Edwards, W B ; Prasad, A ; Troy, K L ; Griffith, J W ; Schnitzer, T J</creator><creatorcontrib>McPherson, J G ; Edwards, W B ; Prasad, A ; Troy, K L ; Griffith, J W ; Schnitzer, T J</creatorcontrib><description>Study Design:
Comparison of diagnostic tests; methodological validation.
Objectives:
Primary: to investigate the precision and reliability of a knee bone mineral density (BMD) assessment protocol that uses an existing dual energy X-ray absorptiometry (DXA) forearm acquisition algorithm in individuals with spinal cord injury (SCI). Secondary: to correlate DXA-based knee areal BMD with volumetric BMD assessments derived from quantitative computed tomography (QCT).
Setting:
Academic medical center, Chicago, IL, USA.
Methods:
Participants: a convenience sample of 12 individuals with acute SCI recruited for an observational study of bone loss and 34 individuals with chronic SCI who were screened for a longitudinal study evaluating interventions to increase BMD. Main outcome measures: root-mean-square standard deviation (RMS-SD) and intra/inter-rater reliability of areal BMD acquired at three knee regions using an existing DXA forearm acquisition algorithm; correlation of DXA-based areal BMD with QCT-derived volumetric BMD.
Results:
The RMS-SD of areal BMD at the distal femoral epiphysis, distal femoral metaphysis and proximal tibial epiphysis averaged 0.021, 0.012 and 0.016 g cm
−2
, respectively, in acute SCI and 0.018, 0.02 and 0.016 g cm
−2
in chronic SCI. All estimates of intra/inter-rater reliability exceeded 97% and DXA-based areal BMD was significantly correlated with QCT-derived volumetric BMD at all knee regions analyzed.
Conclusions:
Existing DXA forearm acquisition algorithms are sufficiently precise and reliable for short-term assessments of knee BMD in individuals with SCI. Future work is necessary to quantify the reliability of this approach in longitudinal investigations and to determine its ability to predict fractures and recovery potential.
Sponsorship:
This work was funded by the Department of Defense, grant number DOD W81XWH-10-1-0951, with partial support from Merck & Co, Inc.</description><identifier>ISSN: 1362-4393</identifier><identifier>EISSN: 1476-5624</identifier><identifier>DOI: 10.1038/sc.2014.122</identifier><identifier>PMID: 25023861</identifier><identifier>CODEN: SPCOFM</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/375/1824 ; 692/700/1421/1846/2771 ; 692/700/1421/2770 ; Absorptiometry, Photon ; Adolescent ; Adult ; Anatomy ; Biomedical and Life Sciences ; Biomedicine ; Bone Diseases - diagnosis ; Bone Diseases - etiology ; Cohort Studies ; Female ; Forearm - diagnostic imaging ; Forearm - pathology ; Human Physiology ; Humans ; Knee - diagnostic imaging ; Male ; Middle Aged ; Neurochemistry ; Neuropsychology ; Neurosciences ; original-article ; Reproducibility of Results ; Spinal Cord Injuries - complications ; Spinal Cord Injuries - pathology ; Tomography Scanners, X-Ray Computed ; Young Adult</subject><ispartof>Spinal cord, 2014-11, Vol.52 (11), p.821-825</ispartof><rights>International Spinal Cord Society 2014</rights><rights>Copyright Nature Publishing Group Nov 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-688fb42e05527037a832845645060bcfa56a2701405070b336090f0d9201c0263</citedby><cites>FETCH-LOGICAL-c494t-688fb42e05527037a832845645060bcfa56a2701405070b336090f0d9201c0263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sc.2014.122$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sc.2014.122$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25023861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McPherson, J G</creatorcontrib><creatorcontrib>Edwards, W B</creatorcontrib><creatorcontrib>Prasad, A</creatorcontrib><creatorcontrib>Troy, K L</creatorcontrib><creatorcontrib>Griffith, J W</creatorcontrib><creatorcontrib>Schnitzer, T J</creatorcontrib><title>Dual energy X-ray absorptiometry of the knee in spinal cord injury: methodology and correlation with quantitative computed tomography</title><title>Spinal cord</title><addtitle>Spinal Cord</addtitle><addtitle>Spinal Cord</addtitle><description>Study Design:
Comparison of diagnostic tests; methodological validation.
Objectives:
Primary: to investigate the precision and reliability of a knee bone mineral density (BMD) assessment protocol that uses an existing dual energy X-ray absorptiometry (DXA) forearm acquisition algorithm in individuals with spinal cord injury (SCI). Secondary: to correlate DXA-based knee areal BMD with volumetric BMD assessments derived from quantitative computed tomography (QCT).
Setting:
Academic medical center, Chicago, IL, USA.
Methods:
Participants: a convenience sample of 12 individuals with acute SCI recruited for an observational study of bone loss and 34 individuals with chronic SCI who were screened for a longitudinal study evaluating interventions to increase BMD. Main outcome measures: root-mean-square standard deviation (RMS-SD) and intra/inter-rater reliability of areal BMD acquired at three knee regions using an existing DXA forearm acquisition algorithm; correlation of DXA-based areal BMD with QCT-derived volumetric BMD.
Results:
The RMS-SD of areal BMD at the distal femoral epiphysis, distal femoral metaphysis and proximal tibial epiphysis averaged 0.021, 0.012 and 0.016 g cm
−2
, respectively, in acute SCI and 0.018, 0.02 and 0.016 g cm
−2
in chronic SCI. All estimates of intra/inter-rater reliability exceeded 97% and DXA-based areal BMD was significantly correlated with QCT-derived volumetric BMD at all knee regions analyzed.
Conclusions:
Existing DXA forearm acquisition algorithms are sufficiently precise and reliable for short-term assessments of knee BMD in individuals with SCI. Future work is necessary to quantify the reliability of this approach in longitudinal investigations and to determine its ability to predict fractures and recovery potential.
Sponsorship:
This work was funded by the Department of Defense, grant number DOD W81XWH-10-1-0951, with partial support from Merck & Co, Inc.</description><subject>692/699/375/1824</subject><subject>692/700/1421/1846/2771</subject><subject>692/700/1421/2770</subject><subject>Absorptiometry, Photon</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Anatomy</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bone Diseases - diagnosis</subject><subject>Bone Diseases - etiology</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Forearm - diagnostic imaging</subject><subject>Forearm - pathology</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Knee - diagnostic imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurochemistry</subject><subject>Neuropsychology</subject><subject>Neurosciences</subject><subject>original-article</subject><subject>Reproducibility of Results</subject><subject>Spinal Cord Injuries - complications</subject><subject>Spinal Cord Injuries - pathology</subject><subject>Tomography Scanners, X-Ray Computed</subject><subject>Young Adult</subject><issn>1362-4393</issn><issn>1476-5624</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1v1DAQhi1UREvhxL2y1EslyDL-TNJbtXxKlbiAxC1yEmc328RObacoP4D_3Vm2VAhx4OTxvM-8I81LyCsGKwaieBubFQcmV4zzJ-SEyVxnSnN5hLXQPJOiFMfkeYw7AChZWTwjx1wBF4VmJ-Tnu9kM1DobNgv9ngWzUFNHH6bU-9GmsFDf0bS19MZZS3tH49Q7nGh8aPG7m8NySRHc-tYPHj2Ma_disINBC0d_9GlLb2fjUp-wc2dRHac52ZYmP_pNMNN2eUGedmaI9uXDe0q-fXj_df0pu_7y8fP66jprZClTpouiqyW3oBTPQeSmELyQSksFGuqmM0obFJgEBTnUQmgooYO2xPs0wLU4JRcH3yn429nGVI19bOwwGGf9HCumteTAS_Y_KOegcs04oud_oTs_B7zSL4rhXqEEUq8PVBN8jMF21RT60YSlYlDtg6xiU-2DrDBIpM8ePOd6tO0j-zs5BN4cgIiS29jwx9J_-N0DDUSmYQ</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>McPherson, J G</creator><creator>Edwards, W B</creator><creator>Prasad, A</creator><creator>Troy, K L</creator><creator>Griffith, J W</creator><creator>Schnitzer, T J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20141101</creationdate><title>Dual energy X-ray absorptiometry of the knee in spinal cord injury: methodology and correlation with quantitative computed tomography</title><author>McPherson, J G ; Edwards, W B ; Prasad, A ; Troy, K L ; Griffith, J W ; Schnitzer, T J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-688fb42e05527037a832845645060bcfa56a2701405070b336090f0d9201c0263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>692/699/375/1824</topic><topic>692/700/1421/1846/2771</topic><topic>692/700/1421/2770</topic><topic>Absorptiometry, Photon</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Anatomy</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bone Diseases - diagnosis</topic><topic>Bone Diseases - etiology</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Forearm - diagnostic imaging</topic><topic>Forearm - pathology</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Knee - diagnostic imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurochemistry</topic><topic>Neuropsychology</topic><topic>Neurosciences</topic><topic>original-article</topic><topic>Reproducibility of Results</topic><topic>Spinal Cord Injuries - complications</topic><topic>Spinal Cord Injuries - pathology</topic><topic>Tomography Scanners, X-Ray Computed</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McPherson, J G</creatorcontrib><creatorcontrib>Edwards, W B</creatorcontrib><creatorcontrib>Prasad, A</creatorcontrib><creatorcontrib>Troy, K L</creatorcontrib><creatorcontrib>Griffith, J W</creatorcontrib><creatorcontrib>Schnitzer, T J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Spinal cord</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McPherson, J G</au><au>Edwards, W B</au><au>Prasad, A</au><au>Troy, K L</au><au>Griffith, J W</au><au>Schnitzer, T J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dual energy X-ray absorptiometry of the knee in spinal cord injury: methodology and correlation with quantitative computed tomography</atitle><jtitle>Spinal cord</jtitle><stitle>Spinal Cord</stitle><addtitle>Spinal Cord</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>52</volume><issue>11</issue><spage>821</spage><epage>825</epage><pages>821-825</pages><issn>1362-4393</issn><eissn>1476-5624</eissn><coden>SPCOFM</coden><abstract>Study Design:
Comparison of diagnostic tests; methodological validation.
Objectives:
Primary: to investigate the precision and reliability of a knee bone mineral density (BMD) assessment protocol that uses an existing dual energy X-ray absorptiometry (DXA) forearm acquisition algorithm in individuals with spinal cord injury (SCI). Secondary: to correlate DXA-based knee areal BMD with volumetric BMD assessments derived from quantitative computed tomography (QCT).
Setting:
Academic medical center, Chicago, IL, USA.
Methods:
Participants: a convenience sample of 12 individuals with acute SCI recruited for an observational study of bone loss and 34 individuals with chronic SCI who were screened for a longitudinal study evaluating interventions to increase BMD. Main outcome measures: root-mean-square standard deviation (RMS-SD) and intra/inter-rater reliability of areal BMD acquired at three knee regions using an existing DXA forearm acquisition algorithm; correlation of DXA-based areal BMD with QCT-derived volumetric BMD.
Results:
The RMS-SD of areal BMD at the distal femoral epiphysis, distal femoral metaphysis and proximal tibial epiphysis averaged 0.021, 0.012 and 0.016 g cm
−2
, respectively, in acute SCI and 0.018, 0.02 and 0.016 g cm
−2
in chronic SCI. All estimates of intra/inter-rater reliability exceeded 97% and DXA-based areal BMD was significantly correlated with QCT-derived volumetric BMD at all knee regions analyzed.
Conclusions:
Existing DXA forearm acquisition algorithms are sufficiently precise and reliable for short-term assessments of knee BMD in individuals with SCI. Future work is necessary to quantify the reliability of this approach in longitudinal investigations and to determine its ability to predict fractures and recovery potential.
Sponsorship:
This work was funded by the Department of Defense, grant number DOD W81XWH-10-1-0951, with partial support from Merck & Co, Inc.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25023861</pmid><doi>10.1038/sc.2014.122</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 692/699/375/1824 692/700/1421/1846/2771 692/700/1421/2770 Absorptiometry, Photon Adolescent Adult Anatomy Biomedical and Life Sciences Biomedicine Bone Diseases - diagnosis Bone Diseases - etiology Cohort Studies Female Forearm - diagnostic imaging Forearm - pathology Human Physiology Humans Knee - diagnostic imaging Male Middle Aged Neurochemistry Neuropsychology Neurosciences original-article Reproducibility of Results Spinal Cord Injuries - complications Spinal Cord Injuries - pathology Tomography Scanners, X-Ray Computed Young Adult |
title | Dual energy X-ray absorptiometry of the knee in spinal cord injury: methodology and correlation with quantitative computed tomography |
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