Dual energy X-ray absorptiometry of the knee in spinal cord injury: methodology and correlation with quantitative computed tomography

Study Design: Comparison of diagnostic tests; methodological validation. Objectives: Primary: to investigate the precision and reliability of a knee bone mineral density (BMD) assessment protocol that uses an existing dual energy X-ray absorptiometry (DXA) forearm acquisition algorithm in individual...

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Veröffentlicht in:Spinal cord 2014-11, Vol.52 (11), p.821-825
Hauptverfasser: McPherson, J G, Edwards, W B, Prasad, A, Troy, K L, Griffith, J W, Schnitzer, T J
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container_issue 11
container_start_page 821
container_title Spinal cord
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creator McPherson, J G
Edwards, W B
Prasad, A
Troy, K L
Griffith, J W
Schnitzer, T J
description Study Design: Comparison of diagnostic tests; methodological validation. Objectives: Primary: to investigate the precision and reliability of a knee bone mineral density (BMD) assessment protocol that uses an existing dual energy X-ray absorptiometry (DXA) forearm acquisition algorithm in individuals with spinal cord injury (SCI). Secondary: to correlate DXA-based knee areal BMD with volumetric BMD assessments derived from quantitative computed tomography (QCT). Setting: Academic medical center, Chicago, IL, USA. Methods: Participants: a convenience sample of 12 individuals with acute SCI recruited for an observational study of bone loss and 34 individuals with chronic SCI who were screened for a longitudinal study evaluating interventions to increase BMD. Main outcome measures: root-mean-square standard deviation (RMS-SD) and intra/inter-rater reliability of areal BMD acquired at three knee regions using an existing DXA forearm acquisition algorithm; correlation of DXA-based areal BMD with QCT-derived volumetric BMD. Results: The RMS-SD of areal BMD at the distal femoral epiphysis, distal femoral metaphysis and proximal tibial epiphysis averaged 0.021, 0.012 and 0.016 g cm −2 , respectively, in acute SCI and 0.018, 0.02 and 0.016 g cm −2 in chronic SCI. All estimates of intra/inter-rater reliability exceeded 97% and DXA-based areal BMD was significantly correlated with QCT-derived volumetric BMD at all knee regions analyzed. Conclusions: Existing DXA forearm acquisition algorithms are sufficiently precise and reliable for short-term assessments of knee BMD in individuals with SCI. Future work is necessary to quantify the reliability of this approach in longitudinal investigations and to determine its ability to predict fractures and recovery potential. Sponsorship: This work was funded by the Department of Defense, grant number DOD W81XWH-10-1-0951, with partial support from Merck & Co, Inc.
doi_str_mv 10.1038/sc.2014.122
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Results: The RMS-SD of areal BMD at the distal femoral epiphysis, distal femoral metaphysis and proximal tibial epiphysis averaged 0.021, 0.012 and 0.016 g cm −2 , respectively, in acute SCI and 0.018, 0.02 and 0.016 g cm −2 in chronic SCI. All estimates of intra/inter-rater reliability exceeded 97% and DXA-based areal BMD was significantly correlated with QCT-derived volumetric BMD at all knee regions analyzed. Conclusions: Existing DXA forearm acquisition algorithms are sufficiently precise and reliable for short-term assessments of knee BMD in individuals with SCI. Future work is necessary to quantify the reliability of this approach in longitudinal investigations and to determine its ability to predict fractures and recovery potential. 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Objectives: Primary: to investigate the precision and reliability of a knee bone mineral density (BMD) assessment protocol that uses an existing dual energy X-ray absorptiometry (DXA) forearm acquisition algorithm in individuals with spinal cord injury (SCI). Secondary: to correlate DXA-based knee areal BMD with volumetric BMD assessments derived from quantitative computed tomography (QCT). Setting: Academic medical center, Chicago, IL, USA. Methods: Participants: a convenience sample of 12 individuals with acute SCI recruited for an observational study of bone loss and 34 individuals with chronic SCI who were screened for a longitudinal study evaluating interventions to increase BMD. Main outcome measures: root-mean-square standard deviation (RMS-SD) and intra/inter-rater reliability of areal BMD acquired at three knee regions using an existing DXA forearm acquisition algorithm; correlation of DXA-based areal BMD with QCT-derived volumetric BMD. 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methodological validation. Objectives: Primary: to investigate the precision and reliability of a knee bone mineral density (BMD) assessment protocol that uses an existing dual energy X-ray absorptiometry (DXA) forearm acquisition algorithm in individuals with spinal cord injury (SCI). Secondary: to correlate DXA-based knee areal BMD with volumetric BMD assessments derived from quantitative computed tomography (QCT). Setting: Academic medical center, Chicago, IL, USA. Methods: Participants: a convenience sample of 12 individuals with acute SCI recruited for an observational study of bone loss and 34 individuals with chronic SCI who were screened for a longitudinal study evaluating interventions to increase BMD. Main outcome measures: root-mean-square standard deviation (RMS-SD) and intra/inter-rater reliability of areal BMD acquired at three knee regions using an existing DXA forearm acquisition algorithm; correlation of DXA-based areal BMD with QCT-derived volumetric BMD. Results: The RMS-SD of areal BMD at the distal femoral epiphysis, distal femoral metaphysis and proximal tibial epiphysis averaged 0.021, 0.012 and 0.016 g cm −2 , respectively, in acute SCI and 0.018, 0.02 and 0.016 g cm −2 in chronic SCI. All estimates of intra/inter-rater reliability exceeded 97% and DXA-based areal BMD was significantly correlated with QCT-derived volumetric BMD at all knee regions analyzed. Conclusions: Existing DXA forearm acquisition algorithms are sufficiently precise and reliable for short-term assessments of knee BMD in individuals with SCI. Future work is necessary to quantify the reliability of this approach in longitudinal investigations and to determine its ability to predict fractures and recovery potential. Sponsorship: This work was funded by the Department of Defense, grant number DOD W81XWH-10-1-0951, with partial support from Merck &amp; Co, Inc.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25023861</pmid><doi>10.1038/sc.2014.122</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects 692/699/375/1824
692/700/1421/1846/2771
692/700/1421/2770
Absorptiometry, Photon
Adolescent
Adult
Anatomy
Biomedical and Life Sciences
Biomedicine
Bone Diseases - diagnosis
Bone Diseases - etiology
Cohort Studies
Female
Forearm - diagnostic imaging
Forearm - pathology
Human Physiology
Humans
Knee - diagnostic imaging
Male
Middle Aged
Neurochemistry
Neuropsychology
Neurosciences
original-article
Reproducibility of Results
Spinal Cord Injuries - complications
Spinal Cord Injuries - pathology
Tomography Scanners, X-Ray Computed
Young Adult
title Dual energy X-ray absorptiometry of the knee in spinal cord injury: methodology and correlation with quantitative computed tomography
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