The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

The NLRP3 inflammasome is involved in IL-1 production and pyroptosis. Pelegrín et al . demonstrate that it is also released extracellularly as a functional proinflammatory particle. Assembly of the NLRP3 inflammasome activates caspase-1 and mediates the processing and release of the leaderless cytok...

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Veröffentlicht in:	Nature immunology 2014-08, Vol.15 (8), p.738-748
Hauptverfasser:	Baroja-Mazo, Alberto, Martín-Sánchez, Fatima, Gomez, Ana I, Martínez, Carlos M, Amores-Iniesta, Joaquín, Compan, Vincent, Barberà-Cremades, Maria, Yagüe, Jordi, Ruiz-Ortiz, Estibaliz, Antón, Jordi, Buján, Segundo, Couillin, Isabelle, Brough, David, Arostegui, Juan I, Pelegrín, Pablo
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/21 13/31 13/51 14/28 14/63 59 631/250/2520 631/250/256/2177 64 64/60 692/699/249/2510/2511 96 Animals Apoptosis Regulatory Proteins Biomedicine CARD Signaling Adaptor Proteins Carrier Proteins - blood Carrier Proteins - genetics Carrier Proteins - immunology Caspase 1 - genetics Caspase 1 - immunology Caspases - genetics Caspases - immunology Cells, Cultured Cryopyrin-Associated Periodic Syndromes - blood Cytoskeletal Proteins - blood Cytoskeletal Proteins - genetics Cytoskeletal Proteins - immunology Genetic aspects HEK293 Cells Humans Immune response Immunology Infectious Diseases Inflammasomes - blood Inflammasomes - immunology Inflammation Inflammation - immunology Interleukin-1beta - blood Interleukin-1beta - immunology Macrophages Macrophages - immunology Mice Mice, Inbred C57BL Mice, Knockout NLR Family, Pyrin Domain-Containing 3 Protein Phagocytosis - immunology Properties Signal Transduction - immunology
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