African-American Race Is a Predictor of Seminal Vesicle Invasion After Radical Prostatectomy

African-American Race Is a Predictor of Seminal Vesicle Invasion After Radical Prostatectomy

Micro-Abstract African-American (AA) men have worse outcomes after definitive treatment for prostate cancer compared to Caucasian (CS) men. Whether this is due to differences in patterns of disease progression within the prostate gland itself it currently unknown. In this report we evaluated 1000+ m...

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Veröffentlicht in:Clinical genitourinary cancer 2015-04, Vol.13 (2), p.e65-e72
Hauptverfasser: Yamoah, Kosj, Walker, Amy, Spangler, Elaine, Zeigler-Johnson, Charnita M, Malkowicz, Bruce, Lee, David I, Dicker, Adam P, Rebbeck, Timothy R, Lal, Priti
Format: Artikel
Sprache:eng
Schlagworte:
Adverse pathologic features invasion
African Americans
African-American
Biochemical failure
Black men
Cohort Studies
Disease Progression
Disparities
European Continental Ancestry Group
Hematology, Oncology and Palliative Medicine
Humans
Male
Middle Aged
Neoplasm Grading
Neoplasm Invasiveness
Prognosis
Prostate cancer
Prostatic Neoplasms - ethnology
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Risk Factors
Seminal vesicle invasion
Seminal Vesicles - pathology
United States - ethnology
Urology
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Zusammenfassung:Micro-Abstract African-American (AA) men have worse outcomes after definitive treatment for prostate cancer compared to Caucasian (CS) men. Whether this is due to differences in patterns of disease progression within the prostate gland itself it currently unknown. In this report we evaluated 1000+ men treated with radical prostatectomy and compared the pattern of disease progression by race. We showed that AA men had higher risk of seminal vesicle invasion when compared to CS men, even when both race had identical risk factors for disease recurrence. This phenomenon may contributor to worse outcomes in the AA population.
ISSN:1558-7673
1938-0682
DOI:10.1016/j.clgc.2014.08.012