A gold glyco-nanoparticle carrying a listeriolysin O peptide and formulated with Advax™ delta inulin adjuvant induces robust T-cell protection against listeria infection

Abstract In the search for an effective vaccine against the human pathogen, Listeria monocytogenes ( Listeria ), gold glyconanoparticles (GNP) loaded with a listeriolysin O peptide LLO91–99 (GNP-LLO) were used to immunise mice, initially using a dendritic cell (DC) vaccine approach, but subsequently...

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Veröffentlicht in:	Vaccine 2015-03, Vol.33 (12), p.1465-1473
Hauptverfasser:	Rodriguez-Del Rio, Estela, Marradi, Marco, Calderon-Gonzalez, Ricardo, Frande-Cabanes, Elisabet, Penadés, Soledad, Petrovsky, Nikolai, Alvarez-Dominguez, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Advax Allergy and Immunology Animals Apoptosis Bacterial Toxins - immunology Bacterial Vaccines - immunology Biocompatibility CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cytokines - immunology Cytokines - metabolism Dendritic cells Dendritic Cells - immunology Development strategies Epitopes, T-Lymphocyte - immunology Glucose Glyconanoparticles Gold Heat-Shock Proteins - immunology Hemolysin Proteins - immunology Hepatitis Immunity, Cellular Immunization Immunogenicity Inulin - immunology Killer Cells, Natural Ligands Listeria Listeria monocytogenes Listeria monocytogenes - immunology Listeriosis Listeriosis - prevention & control Lymphocytes Metal Nanoparticles Mice Mice, Inbred BALB C Peptides Spleen - cytology T cell receptors T-Lymphocytes - immunology Vaccination Vaccines West Nile virus
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