Antigenic site variation in foot-and-mouth disease virus serotype O grown under vaccinal serum antibodies in vitro

•Neutralizing antibody-resistant populations of FMD virus serotype O were characterized.•Amino acid substitutions were fixed within antigenic sites of serotype O except site 4 and 5.•Substitutions outside of the antigenic sites might be significant for immune escape.•In majority of the variant popul...

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