Evaluation of Mycobacterium bovis double knockout mce2-phoP as candidate vaccine against bovine tuberculosis

Summary In this study, a Mycobacterium bovis knockout strain in phoP-phoR and mce2 operons was tested as an antituberculosis experimental vaccine in animal models. The double mutant strain was significantly more attenuated than the wild type strain in inmunocompetent and inmunodeficient mice. Vaccin...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2015-03, Vol.95 (2), p.186-189
Hauptverfasser:	García, Elizabeth, Bianco, María V, Gravisaco, María José, Rocha, Rosana V, Blanco, Federico C, Bigi, Fabiana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - genetics Bacterial Proteins - genetics Bovine tuberculosis Cattle Colony Count, Microbial Cytokines - biosynthesis Disease Models, Animal Gene Knockout Techniques Infectious Disease Mice, Inbred BALB C Mice, Nude Mycobacerium bovis Mycobacterium bovis - genetics Mycobacterium bovis - growth & development Mycobacterium bovis - pathogenicity phoP Pulmonary/Respiratory Th1 Cells - immunology Tuberculosis Vaccines - genetics Tuberculosis Vaccines - immunology Tuberculosis Vaccines - toxicity Tuberculosis, Bovine - prevention & control Vaccine Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Vaccines, Attenuated - toxicity Virulence - genetics
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Zusammenfassung:	Summary In this study, a Mycobacterium bovis knockout strain in phoP-phoR and mce2 operons was tested as an antituberculosis experimental vaccine in animal models. The double mutant strain was significantly more attenuated than the wild type strain in inmunocompetent and inmunodeficient mice. Vaccination with the double mutant protected mice against challenge with a virulent M. bovis strain.
ISSN:	1472-9792 1873-281X
DOI:	10.1016/j.tube.2015.01.001