Arachidonic acid induces brain endothelial cell apoptosis via p38-MAPK and intracellular calcium signaling

Arachidonic acid (AA), a bioactive fatty acid whose levels increase during neuroinflammation, contributes to cerebral vascular damage and dysfunction. However, the mode of injury and underlying signaling mechanisms remain unknown. Challenge of primary human brain endothelial cells (HBECs) with AA ac...

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Veröffentlicht in:	Microvascular research 2015-03, Vol.98, p.145-158
Hauptverfasser:	Evans, Justin, Ko, YooSeung, Mata, Wilmer, Saquib, Muhammad, Eldridge, Joel, Cohen-Gadol, Aaron, Leaver, H. Anne, Wang, Shukun, Rizzo, Maria Teresa
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Arachidonic Acid Arachidonic Acid - metabolism Brain - cytology Brain endothelial cells Calcium Calcium - metabolism Calcium Signaling Caspase 3 - metabolism Cell Proliferation Cells, Cultured Endothelial Cells - metabolism Endothelial Cells - pathology Gene Silencing HSP27 Heat-Shock Proteins - metabolism Humans Inflammation - metabolism Intracellular Signaling Peptides and Proteins - metabolism Lipoxygenases - metabolism MAP Kinase Signaling System Mitochondria - pathology Mitogen-Activated Protein Kinase 14 - metabolism p38-MAPK Protein-Serine-Threonine Kinases - metabolism RNA Interference
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