Hydrogen sulfide protects testicular germ cells against heat-induced injury

•CBS, CSE and 3MST are all expressed in mouse testicular germ cells.•Heat stress caused CBS and CSE down-regulation and decreased H2S level in mouse testis.•Heat stress promoted germ cells apoptosis via an intrinsic pathway.•H2S ameliorates heat-induced germ cells apoptosis through an antioxidant me...

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Veröffentlicht in:	Nitric oxide 2015-04, Vol.46, p.165-171
Hauptverfasser:	Li, Guang, Xie, Zhi-Zhong, Chua, Jason M.W., Wong, P.C., Bian, Jinsong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant Antioxidants - metabolism Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Cell Survival - drug effects Germ Cells - drug effects Germ Cells - metabolism Heat stress Heat-Shock Response - drug effects Hydrogen sulfide Hydrogen Sulfide - metabolism Hydrogen Sulfide - pharmacology Infertility Male Mice Mice, Inbred C57BL Reactive Oxygen Species - metabolism Testicular germ cell Testis - cytology Testis - drug effects Testis - injuries
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