Valproic acid-induced rapid changes of met-enkephalin levels in rat brain: Probable association with abstinence behavior and anticonvulsant activity

Valproic acid (VPA) induces abstinence behavior and analgesia and displays an anticonvulsant effect, but its exact mechanism of action is not yet clear. In order to view whether proenkephalin derived-peptides are involved in the mechanism of VPA-induced behavior, we analyzed immunoreactive-met-enkep...

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Veröffentlicht in:	Neuropeptides (Edinburgh) 1994-09, Vol.27 (3), p.203-210
Hauptverfasser:	Asai, M., Talavera, E., Massarini, A., Zubieta, M., Vindrola, O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Brain Chemistry - drug effects Chromatography, Gel Chromatography, High Pressure Liquid Enkephalin, Methionine - metabolism Epilepsy, Tonic-Clonic - chemically induced Epilepsy, Tonic-Clonic - prevention & control Injections, Intraperitoneal Male Medical sciences Neuropharmacology Pentylenetetrazole Pharmacology. Drug treatments Rats Rats, Wistar Substance Withdrawal Syndrome - psychology Valproic Acid - adverse effects Valproic Acid - pharmacology
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