Barbiturate anaesthesia reduces the neurotoxic effects of quinolinate but not ibotenate in the rat pedunculopontine tegmental nucleus
We have previously demonstrated that ibotenate (IBO) injected into the pedunculopontine tegmental nucleus (PPTg) damages all neurones there while quinolinate (QUIN) makes relatively selective lesions of cholinergic neurones. We now compare the effects of two anaesthetics, sodium pentobarbitone and A...
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| Veröffentlicht in: | Neuroscience letters 1993-06, Vol.156 (1), p.78-82 |
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| creator | Inglis, Wendy L. Dunbar, Jay S. Winn, Philip |
| description | We have previously demonstrated that ibotenate (IBO) injected into the pedunculopontine tegmental nucleus (PPTg) damages all neurones there while quinolinate (QUIN) makes relatively selective lesions of cholinergic neurones. We now compare the effects of two anaesthetics, sodium pentobarbitone and Avertin (tribromoethanol/
tert-amylalcohol dissolved in ethanol, saline and phosphate buffer), on three doses of IBO and QUIN in the PPTg. Diaphorase-positive cell loss after QUIN was attenuated under barbiturate, the relative selectivity of QUIN for diaphorase-positive neurones was lost and lesion volumes were uniformly small compared with lesions made under Avertin anaesthesia. IBO toxicity was unaffected by anaesthesia. These data are discussed with reference to the actions of excitotoxins at glutamate receptor subtypes and interactions of barbiturates with the GABA
A receptor. |
| doi_str_mv | 10.1016/0304-3940(93)90444-P |
| format | Article |
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tert-amylalcohol dissolved in ethanol, saline and phosphate buffer), on three doses of IBO and QUIN in the PPTg. Diaphorase-positive cell loss after QUIN was attenuated under barbiturate, the relative selectivity of QUIN for diaphorase-positive neurones was lost and lesion volumes were uniformly small compared with lesions made under Avertin anaesthesia. IBO toxicity was unaffected by anaesthesia. These data are discussed with reference to the actions of excitotoxins at glutamate receptor subtypes and interactions of barbiturates with the GABA
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tert-amylalcohol dissolved in ethanol, saline and phosphate buffer), on three doses of IBO and QUIN in the PPTg. Diaphorase-positive cell loss after QUIN was attenuated under barbiturate, the relative selectivity of QUIN for diaphorase-positive neurones was lost and lesion volumes were uniformly small compared with lesions made under Avertin anaesthesia. IBO toxicity was unaffected by anaesthesia. These data are discussed with reference to the actions of excitotoxins at glutamate receptor subtypes and interactions of barbiturates with the GABA
A receptor.</description><subject>Anaesthesia</subject><subject>Anesthesia, General</subject><subject>Anesthetics - pharmacology</subject><subject>Animals</subject><subject>Avertin</subject><subject>Barbiturate</subject><subject>Diaphorase</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ethanol - analogs & derivatives</subject><subject>Ethanol - pharmacology</subject><subject>Ibotenate</subject><subject>Ibotenic Acid - antagonists & inhibitors</subject><subject>Ibotenic Acid - toxicity</subject><subject>Male</subject><subject>Neurons - drug effects</subject><subject>Neurons - pathology</subject><subject>Neurotoxins - antagonists & inhibitors</subject><subject>Neurotoxins - toxicity</subject><subject>Pedunculopontine tegmental nucleus</subject><subject>Pentobarbital - pharmacology</subject><subject>Pons - drug effects</subject><subject>Pons - pathology</subject><subject>Quinolinate</subject><subject>Quinolinic Acid - antagonists & inhibitors</subject><subject>Quinolinic Acid - toxicity</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtqHDEQRYWJGU8c_0EMWplk0Y7UUj-0MSRDYgcGPIvZC7VUHcv0SDN6GOcD_N_RPPAyq6Kq7r1FHYQ-U3JLCW2_EUZ4xQQnXwT7KgjnvFqdoTntu7rqRFd_QPN3yQX6GOMzIaShDZ-hWc8pp4LP0dsPFQabclAJsHIKYnqCaBUOYLKGiEuLHeTgk3-1GsM4gk4R-xHvsnV-sm7vHHLCzidsB5_gMLHuYC25eFuinM6T33qXrAOc4M8GXFITdllPkOMndD6qKcLVqV6i9a-f68VDtXy8_734vqw06_tUCdO3huhx6JoehDG9rjtDG82F4EJR03Z05Ko3NdOma0ljxMgJUDG0tGXMsEt0c4zdBr_L5VW5sVHDNCkHPkdJ25YTWtMi5EehDj7GAKPcBrtR4a-kRO7hyz1ZuScrBZMH-HJVbNen_DxswLybTrTL_u64h_Lji4Ugo7bgNBgbClVpvP3_gX8jWpdb</recordid><startdate>19930625</startdate><enddate>19930625</enddate><creator>Inglis, Wendy L.</creator><creator>Dunbar, Jay S.</creator><creator>Winn, Philip</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19930625</creationdate><title>Barbiturate anaesthesia reduces the neurotoxic effects of quinolinate but not ibotenate in the rat pedunculopontine tegmental nucleus</title><author>Inglis, Wendy L. ; Dunbar, Jay S. ; Winn, Philip</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-9d86d0cfb758e9dd8c27d15c49949a1d671f4a8d23cd7605d9f40e19b61633d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Anaesthesia</topic><topic>Anesthesia, General</topic><topic>Anesthetics - pharmacology</topic><topic>Animals</topic><topic>Avertin</topic><topic>Barbiturate</topic><topic>Diaphorase</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ethanol - analogs & derivatives</topic><topic>Ethanol - pharmacology</topic><topic>Ibotenate</topic><topic>Ibotenic Acid - antagonists & inhibitors</topic><topic>Ibotenic Acid - toxicity</topic><topic>Male</topic><topic>Neurons - drug effects</topic><topic>Neurons - pathology</topic><topic>Neurotoxins - antagonists & inhibitors</topic><topic>Neurotoxins - toxicity</topic><topic>Pedunculopontine tegmental nucleus</topic><topic>Pentobarbital - pharmacology</topic><topic>Pons - drug effects</topic><topic>Pons - pathology</topic><topic>Quinolinate</topic><topic>Quinolinic Acid - antagonists & inhibitors</topic><topic>Quinolinic Acid - toxicity</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inglis, Wendy L.</creatorcontrib><creatorcontrib>Dunbar, Jay S.</creatorcontrib><creatorcontrib>Winn, Philip</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inglis, Wendy L.</au><au>Dunbar, Jay S.</au><au>Winn, Philip</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Barbiturate anaesthesia reduces the neurotoxic effects of quinolinate but not ibotenate in the rat pedunculopontine tegmental nucleus</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1993-06-25</date><risdate>1993</risdate><volume>156</volume><issue>1</issue><spage>78</spage><epage>82</epage><pages>78-82</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>We have previously demonstrated that ibotenate (IBO) injected into the pedunculopontine tegmental nucleus (PPTg) damages all neurones there while quinolinate (QUIN) makes relatively selective lesions of cholinergic neurones. We now compare the effects of two anaesthetics, sodium pentobarbitone and Avertin (tribromoethanol/
tert-amylalcohol dissolved in ethanol, saline and phosphate buffer), on three doses of IBO and QUIN in the PPTg. Diaphorase-positive cell loss after QUIN was attenuated under barbiturate, the relative selectivity of QUIN for diaphorase-positive neurones was lost and lesion volumes were uniformly small compared with lesions made under Avertin anaesthesia. IBO toxicity was unaffected by anaesthesia. These data are discussed with reference to the actions of excitotoxins at glutamate receptor subtypes and interactions of barbiturates with the GABA
A receptor.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>8414194</pmid><doi>10.1016/0304-3940(93)90444-P</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1993-06, Vol.156 (1), p.78-82 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anaesthesia Anesthesia, General Anesthetics - pharmacology Animals Avertin Barbiturate Diaphorase Dose-Response Relationship, Drug Ethanol - analogs & derivatives Ethanol - pharmacology Ibotenate Ibotenic Acid - antagonists & inhibitors Ibotenic Acid - toxicity Male Neurons - drug effects Neurons - pathology Neurotoxins - antagonists & inhibitors Neurotoxins - toxicity Pedunculopontine tegmental nucleus Pentobarbital - pharmacology Pons - drug effects Pons - pathology Quinolinate Quinolinic Acid - antagonists & inhibitors Quinolinic Acid - toxicity Rat Rats Rats, Inbred Strains |
| title | Barbiturate anaesthesia reduces the neurotoxic effects of quinolinate but not ibotenate in the rat pedunculopontine tegmental nucleus |
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