Effects of intracerebral dopaminergic grafts on behavioural deficits induced by neonatal 6-hydroxydopamine lesions of the mesotelencephalic dopaminergic pathway

The functional capabilities of dopamine neuron-rich grafts implanted into the accumbens and striatal regions in neonatal rats were evaluated in a series of behavioural tests. The ascending mesotelencephalic dopaminergic system of three-day-old rat pups was bilaterally lesioned by injecting 6-hydroxy...

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Veröffentlicht in:	Neuroscience 1993-05, Vol.54 (2), p.499-511
Hauptverfasser:	Abrous, D.N., Choulli, K., Rouge-Pont, F., Simon, H., Le Moal, M., Herman, J.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences Brain Tissue Transplantation - physiology Corpus Striatum Degeneration. Regeneration. Wound healing. Graft Dopamine - physiology Fetal Tissue Transplantation - physiology Fundamental and applied biological sciences. Psychology Hypothalamic Area, Lateral - drug effects Hypothalamic Area, Lateral - pathology Mesencephalon - drug effects Mesencephalon - pathology Mesencephalon - transplantation Motor Activity - drug effects Motor Activity - physiology Neurons - physiology Neurons - transplantation Oxidopamine - toxicity Rats Rats, Wistar Telencephalon - drug effects Telencephalon - pathology Vertebrates: anatomy and physiology, studies on body, several organs or systems
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