Berberine improves endothelial function by inhibiting endoplasmic reticulum stress in the carotid arteries of spontaneously hypertensive rats

Activation of endoplasmic reticulum (ER) stress in endothelial cells leads to increased oxidative stress and often results in cell death, which has been implicated in hypertension. The present study investigated the effects of berberine, a botanical alkaloid purified from Coptidis rhizoma, on ER str...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-03, Vol.458 (4), p.796-801
Hauptverfasser:	Liu, Limei, Liu, Jian, Huang, Zhengxiang, Yu, Xiaoxing, Zhang, Xinyu, Dou, Dou, Huang, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Berberine - pharmacology Carotid Arteries - drug effects Carotid Arteries - metabolism Carotid Arteries - pathology Carotid artery Cyclooxygenase Cyclooxygenase 2 - metabolism Endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Endothelial function Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Enzyme Activation - drug effects Hypertension - drug therapy Hypertension - metabolism Hypertension - pathology Male Rats Rats, Inbred SHR Rats, Inbred WKY Reactive Oxygen Species - metabolism Spontaneously hypertensive rats
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