Image analysis of neuritic regeneration by adult rat dorsal root ganglion neurons in culture: quantification of the neurotoxicity of anticancer agents and of its prevention by nerve growth factor or basic fibroblast growth factor but not brain-derived neurotrophic factor or neurotrophin-3

Peripheral neuropathies are a common side effect of chemotherapeutic agents, particularly antineoplastic drugs such as taxol, cisplatin, or vinca-alkaloids (vincristine, vinblastine, vindesine). Using dissociated cultures of adult rat dorsal root ganglion (DRG) neurons and video image analysis after...

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Veröffentlicht in:	Journal of neuroscience methods 1994-07, Vol.53 (1), p.111-122
Hauptverfasser:	Malgrange, B., Delrée, P., Rigo, J.M., Baron, H., Moonen, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - toxicity Basic fibroblast growth factor Biological and medical sciences Brain-Derived Neurotrophic Factor Cell Division - drug effects Cells, Cultured Cisplatin - toxicity Colchicine - toxicity Dorsal root ganglion Dose-Response Relationship, Drug Fibroblast Growth Factor 2 - pharmacology Ganglia, Spinal - cytology Ganglia, Spinal - physiology Image Processing, Computer-Assisted Male Medical sciences Nerve growth factor Nerve Growth Factors - pharmacology Nerve Regeneration - drug effects Nerve Tissue Proteins - pharmacology Neurites - drug effects Neurites - ultrastructure Neurofilament Proteins - analysis Neurons - drug effects Neurons - physiology Neuropharmacology Neuroprotective agent Neurotrophin 3 Paclitaxel - toxicity Peripheral neuropathy Pharmacology. Drug treatments Rats Rats, Wistar Video image analysis Videotape Recording Vinca Alkaloids - toxicity
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