Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo , mice homozygous for a targeted mutation in the myogenin gene were generated. These mice survive fetal development but die immediately aft...
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| Veröffentlicht in: | Nature (London) 1993-08, Vol.364 (6437), p.501-506 |
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| creator | Hasty, Paul Bradley, Allan Morris, Julia H. Edmondson, Diane G. Venuti, Judith M. Olson, Eric N. Klein, William H. |
| description | Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role
in vivo
, mice homozygous for a targeted mutation in the
myogenin
gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle. |
| doi_str_mv | 10.1038/364501a0 |
| format | Article |
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in vivo
, mice homozygous for a targeted mutation in the
myogenin
gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/364501a0</identifier><identifier>PMID: 8393145</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Animals, Newborn - anatomy & histology ; Animals, Newborn - genetics ; Biological and medical sciences ; Blotting, Northern ; Blotting, Western ; Classical genetics, quantitative genetics, hybrids ; Embryonic and Fetal Development - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Genes, Lethal ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Humanities and Social Sciences ; Male ; Mice ; Mice, Mutant Strains ; multidisciplinary ; Muscle Proteins - genetics ; Muscle Proteins - physiology ; Muscles - anatomy & histology ; Muscles - cytology ; Muscles - embryology ; Muscular system ; Mutagenesis ; Mutation ; MyoD Protein ; Myogenin ; Phenotype ; RNA, Messenger - genetics ; Rodents ; Science ; Science (multidisciplinary) ; Trans-Activators - genetics ; Trans-Activators - physiology ; Vertebrata</subject><ispartof>Nature (London), 1993-08, Vol.364 (6437), p.501-506</ispartof><rights>Springer Nature Limited 1993</rights><rights>1993 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Aug 5, 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-d468656378a4569d960ce19f1e1b746c9fb044ce3ee3ec5d06ee6c2dd8ca08663</citedby><cites>FETCH-LOGICAL-c399t-d468656378a4569d960ce19f1e1b746c9fb044ce3ee3ec5d06ee6c2dd8ca08663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/364501a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/364501a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4839264$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8393145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasty, Paul</creatorcontrib><creatorcontrib>Bradley, Allan</creatorcontrib><creatorcontrib>Morris, Julia H.</creatorcontrib><creatorcontrib>Edmondson, Diane G.</creatorcontrib><creatorcontrib>Venuti, Judith M.</creatorcontrib><creatorcontrib>Olson, Eric N.</creatorcontrib><creatorcontrib>Klein, William H.</creatorcontrib><title>Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role
in vivo
, mice homozygous for a targeted mutation in the
myogenin
gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle.</description><subject>Animals</subject><subject>Animals, Newborn - anatomy & histology</subject><subject>Animals, Newborn - genetics</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Blotting, Western</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Embryonic and Fetal Development - genetics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Lethal</subject><subject>Genetics</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Humanities and Social Sciences</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>multidisciplinary</subject><subject>Muscle Proteins - genetics</subject><subject>Muscle Proteins - physiology</subject><subject>Muscles - anatomy & histology</subject><subject>Muscles - cytology</subject><subject>Muscles - embryology</subject><subject>Muscular system</subject><subject>Mutagenesis</subject><subject>Mutation</subject><subject>MyoD Protein</subject><subject>Myogenin</subject><subject>Phenotype</subject><subject>RNA, Messenger - genetics</subject><subject>Rodents</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Trans-Activators - genetics</subject><subject>Trans-Activators - physiology</subject><subject>Vertebrata</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNplkE9LxDAQxYMouq6CX0AIIqKHatKkaXsU8R8oXvTipWST6RppU01SZL-9I7sqKISEyfsx8-YRssfZKWeiOhNKFoxrtkYmXJYqk6oq18mEsbzKWCXUFtmO8ZUxVvBSbpLNStSCy2JCnu_HaDqgFlpnHHizoNpb6mHwOukO_3V6oc7T3hmgHw4LTZMOc0hgaT8mndzgv4D0ArRfDHPwWOANO2Sj1V2E3dU7JU9Xl48XN9ndw_XtxfldZkRdp8yiV1UoUVZaFqq2tWIGeN1y4LNSKlO3MyalAQF4TGGZAlAmt7YymlVKiSk5WvZ9C8P7CDE1vYsGuk7jFmNsODJlXnAED_6Ar8MYPHprchxRcI5RTcnxEjJhiDFA27wF1-uwaDhrvrJuvrNGdH_Vb5z1YH_AVbioH650HY3u2qC9cfEHk8jlSiJ2ssQiKn4O4dfWv5GfvHGR9w</recordid><startdate>19930805</startdate><enddate>19930805</enddate><creator>Hasty, Paul</creator><creator>Bradley, Allan</creator><creator>Morris, Julia H.</creator><creator>Edmondson, Diane G.</creator><creator>Venuti, Judith M.</creator><creator>Olson, Eric N.</creator><creator>Klein, William H.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope></search><sort><creationdate>19930805</creationdate><title>Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene</title><author>Hasty, Paul ; Bradley, Allan ; Morris, Julia H. ; Edmondson, Diane G. ; Venuti, Judith M. ; Olson, Eric N. ; Klein, William H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-d468656378a4569d960ce19f1e1b746c9fb044ce3ee3ec5d06ee6c2dd8ca08663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Animals, Newborn - anatomy & histology</topic><topic>Animals, Newborn - genetics</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Blotting, Western</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Embryonic and Fetal Development - genetics</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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To test myogenin's role
in vivo
, mice homozygous for a targeted mutation in the
myogenin
gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8393145</pmid><doi>10.1038/364501a0</doi><tpages>6</tpages></addata></record> |
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| ispartof | Nature (London), 1993-08, Vol.364 (6437), p.501-506 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature |
| subjects | Animals Animals, Newborn - anatomy & histology Animals, Newborn - genetics Biological and medical sciences Blotting, Northern Blotting, Western Classical genetics, quantitative genetics, hybrids Embryonic and Fetal Development - genetics Female Fundamental and applied biological sciences. Psychology Genes, Lethal Genetics Genetics of eukaryotes. Biological and molecular evolution Humanities and Social Sciences Male Mice Mice, Mutant Strains multidisciplinary Muscle Proteins - genetics Muscle Proteins - physiology Muscles - anatomy & histology Muscles - cytology Muscles - embryology Muscular system Mutagenesis Mutation MyoD Protein Myogenin Phenotype RNA, Messenger - genetics Rodents Science Science (multidisciplinary) Trans-Activators - genetics Trans-Activators - physiology Vertebrata |
| title | Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene |
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