Dose-Response Relationships in Mice Following Subchronic Exposure to 2,3,7,8-Tetrachlorodibenzo- p-dioxin: CYP1A1, CYP1A2, Estrogen Receptor, and Protein Tyrosine Phosphorylation

The dose-response relationships for different endpoints in different tissues were compared in response to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) treatment. TCDD was administered 5 days a week for 13 weeks at doses ranging from 1.5 to 150 ng/kg/day to female B6C3F1 mice. Ethoxyresorufin- O-deeth...

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Veröffentlicht in:	Toxicology and applied pharmacology 1994, Vol.124 (1), p.82-90
Hauptverfasser:	Devito, M.J., Ma, X.F., Babish, J.G., Menache, M., Birnbaum, L.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Cytochrome P-450 CYP1A1 Cytochrome P-450 Enzyme System - drug effects Cytochrome P-450 Enzyme System - metabolism Dose-Response Relationship, Drug Drug Administration Schedule Female Liver - drug effects Liver - metabolism Lung - drug effects Lung - metabolism Medical sciences Mice Mice, Inbred Strains Microsomes - drug effects Microsomes - enzymology Oxidoreductases - drug effects Oxidoreductases - metabolism Phosphorylation - drug effects Polychlorinated Dibenzodioxins - administration & dosage Polychlorinated Dibenzodioxins - toxicity Receptors, Estrogen - drug effects Receptors, Estrogen - metabolism Skin - drug effects Skin - metabolism Subcellular Fractions Toxicology Tyrosine - drug effects Tyrosine - metabolism Uterus - drug effects Uterus - metabolism Various organic compounds
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