Analysis of TGF-β1- and drug-induced epithelial–mesenchymal transition in cultured alveolar epithelial cell line RLE/Abca3

In this study, we examined the induction of epithelial–mesenchymal transition (EMT) by transforming growth factor (TGF)-β1 and drugs in genetically engineered type II alveolar epithelial cell line RLE/Abca3. Treatment of RLE/Abca3 cells with TGF-β1 induced marked changes in cell morphology from epit...

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Veröffentlicht in:	Drug metabolism and pharmacokinetics 2015-02, Vol.30 (1), p.111-118
Hauptverfasser:	Takano, Mikihisa, Yamamoto, Chieko, Yamaguchi, Koki, Kawami, Masashi, Yumoto, Ryoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Alveolar epithelial cells Animals ATP-Binding Cassette Transporters - genetics Bleomycin Bleomycin - pharmacology Cell Culture Techniques Cell Line, Tumor Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial-Mesenchymal Transition - drug effects Epithelial–mesenchymal transition Humans Keratin-19 - metabolism Methotrexate Methotrexate - pharmacology Microscopy, Confocal Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology Pulmonary fibrosis Pyridones - pharmacology Rats Real-Time Polymerase Chain Reaction TGF-β1 Transforming Growth Factor beta1 - pharmacology
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