Megakaryocytic Leukemia 1 Directs a Histone H3 Lysine 4 Methyltransferase Complex to Regulate Hypoxic Pulmonary Hypertension

Enhanced interaction between vascular endothelial cells and circulating leukocytes, as a result of transcriptional activation of cell adhesion molecules (CAM), helps establish a proinflammatory milieu contributing to the pathogenesis of chronic hypoxia-induced pulmonary hypertension. The molecular s...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2015-04, Vol.65 (4), p.821-833
Hauptverfasser:	Chen, Dewei, Yang, Yuyu, Cheng, Xian, Fang, Fei, Xu, Gang, Yuan, Zhibin, Xia, Jun, Kong, Hui, Xie, Weiping, Wang, Hong, Fang, Mingming, Gao, Yuqi, Xu, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Epigenesis, Genetic Gene Expression Regulation Hypertension, Pulmonary - etiology Hypertension, Pulmonary - genetics Hypertension, Pulmonary - metabolism Hypoxia - etiology Hypoxia - genetics Hypoxia - metabolism Leukemia, Megakaryoblastic, Acute - complications Leukemia, Megakaryoblastic, Acute - genetics Leukemia, Megakaryoblastic, Acute - metabolism Mice Mice, Knockout Polymerase Chain Reaction Pulmonary Wedge Pressure RNA - genetics Trans-Activators - biosynthesis Trans-Activators - genetics Transcriptional Activation Vasodilation
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