Dietary determinants for Hb-acrylamide and Hb-glycidamide adducts in Danish non-smoking women
Acrylamide (AA) is a probable human carcinogen that is formed in heat-treated carbohydrate-rich foods. The validity of FFQ to assess AA exposure has been questioned. The aim of the present cross-sectional study was to investigate dietary determinants of Hb-AA and Hb-glycidamide (GA) adducts. The stu...
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| Veröffentlicht in: | British journal of nutrition 2011-05, Vol.105 (9), p.1381-1387 |
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| creator | Outzen, Malene Egeberg, Rikke Dragsted, Lars Christensen, Jane Olesen, Pelle T. Frandsen, Henrik Overvad, Kim Tjønneland, Anne Olsen, Anja |
| description | Acrylamide (AA) is a probable human carcinogen that is formed in heat-treated carbohydrate-rich foods. The validity of FFQ to assess AA exposure has been questioned. The aim of the present cross-sectional study was to investigate dietary determinants of Hb-AA and Hb-glycidamide (GA) adducts. The study included 537 non-smoking women aged 50–65 years who participated in the Diet, Cancer and Health cohort (1993–97). At study baseline, blood samples and information on dietary and lifestyle variables obtained from self-administered questionnaires were collected. From blood samples, Hb-AA and Hb-GA in erythrocytes were analysed by liquid chromatography/MS/MS. Dietary determinants were evaluated by multiple linear regression analyses adjusted for age and smoking behaviour among ex-smokers. The median for Hb-AA was 35 pmol/g globin (5th percentile 17, 95th percentile 89) and for Hb-GA 21 pmol/g globin (5th percentile 8, 95th percentile 49). Of the dietary factors studied, intakes of coffee and chips were statistically significantly associated with a 4 % per 200 g/d (95 % CI 2, 7; P |
| doi_str_mv | 10.1017/S0007114510005003 |
| format | Article |
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The validity of FFQ to assess AA exposure has been questioned. The aim of the present cross-sectional study was to investigate dietary determinants of Hb-AA and Hb-glycidamide (GA) adducts. The study included 537 non-smoking women aged 50–65 years who participated in the Diet, Cancer and Health cohort (1993–97). At study baseline, blood samples and information on dietary and lifestyle variables obtained from self-administered questionnaires were collected. From blood samples, Hb-AA and Hb-GA in erythrocytes were analysed by liquid chromatography/MS/MS. Dietary determinants were evaluated by multiple linear regression analyses adjusted for age and smoking behaviour among ex-smokers. The median for Hb-AA was 35 pmol/g globin (5th percentile 17, 95th percentile 89) and for Hb-GA 21 pmol/g globin (5th percentile 8, 95th percentile 49). Of the dietary factors studied, intakes of coffee and chips were statistically significantly associated with a 4 % per 200 g/d (95 % CI 2, 7; P < 0·0001) and an 18 % per 5 g/d (95 % CI 6, 31; P = 0·002) higher Hb-AA, respectively. This model explained 17 % of the variation in Hb-AA. Intakes of coffee and biscuits/crackers were statistically significantly associated with a 3 % per 200 g/d (95 % CI 1, 6; P = 0·005) and 12 % per 10 g/d (95 % CI 3, 23; P = 0·01) higher Hb-GA, respectively. This model explained 12 % of the variation in Hb-GA. In conclusion, only a few dietary determinants of Hb-AA and Hb-GA were identified. Thus, the present study implies that dietary intake measured by an FFQ explains only to a limited extent the variation in Hb-AA and Hb-GA concentrations.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114510005003</identifier><identifier>PMID: 21272397</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Acrylamide ; Acrylamide - chemistry ; Acrylamide - metabolism ; acrylamides ; Biological and medical sciences ; biscuits ; Blood ; Blood tests ; Carcinogenesis, carcinogens and anticarcinogens ; Carcinogens ; Case-Control Studies ; chemistry ; Coffee ; crackers ; cross-sectional studies ; Denmark ; Diet ; Dietary Surveys and Nutritional Epidemiology ; Epoxy Compounds ; Epoxy Compounds - chemistry ; Epoxy Compounds - metabolism ; erythrocytes ; Feeding Behavior ; Female ; food intake ; Foods and miscellaneous ; Hemoglobins ; Hemoglobins - chemistry ; Hemoglobins - metabolism ; Humans ; lifestyle ; linear models ; Liquid chromatography ; Medical sciences ; metabolism ; Middle Aged ; Postmenopause ; questionnaires ; regression analysis ; Risk Factors ; Smoking ; Tumors ; Women</subject><ispartof>British journal of nutrition, 2011-05, Vol.105 (9), p.1381-1387</ispartof><rights>Copyright © The Authors 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-9312d90850022f0be6d192b8104b921f2d8dff005be859c147fed56657130ab53</citedby><cites>FETCH-LOGICAL-c501t-9312d90850022f0be6d192b8104b921f2d8dff005be859c147fed56657130ab53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114510005003/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24167422$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21272397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Outzen, Malene</creatorcontrib><creatorcontrib>Egeberg, Rikke</creatorcontrib><creatorcontrib>Dragsted, Lars</creatorcontrib><creatorcontrib>Christensen, Jane</creatorcontrib><creatorcontrib>Olesen, Pelle T.</creatorcontrib><creatorcontrib>Frandsen, Henrik</creatorcontrib><creatorcontrib>Overvad, Kim</creatorcontrib><creatorcontrib>Tjønneland, Anne</creatorcontrib><creatorcontrib>Olsen, Anja</creatorcontrib><title>Dietary determinants for Hb-acrylamide and Hb-glycidamide adducts in Danish non-smoking women</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Acrylamide (AA) is a probable human carcinogen that is formed in heat-treated carbohydrate-rich foods. The validity of FFQ to assess AA exposure has been questioned. The aim of the present cross-sectional study was to investigate dietary determinants of Hb-AA and Hb-glycidamide (GA) adducts. The study included 537 non-smoking women aged 50–65 years who participated in the Diet, Cancer and Health cohort (1993–97). At study baseline, blood samples and information on dietary and lifestyle variables obtained from self-administered questionnaires were collected. From blood samples, Hb-AA and Hb-GA in erythrocytes were analysed by liquid chromatography/MS/MS. Dietary determinants were evaluated by multiple linear regression analyses adjusted for age and smoking behaviour among ex-smokers. The median for Hb-AA was 35 pmol/g globin (5th percentile 17, 95th percentile 89) and for Hb-GA 21 pmol/g globin (5th percentile 8, 95th percentile 49). Of the dietary factors studied, intakes of coffee and chips were statistically significantly associated with a 4 % per 200 g/d (95 % CI 2, 7; P < 0·0001) and an 18 % per 5 g/d (95 % CI 6, 31; P = 0·002) higher Hb-AA, respectively. This model explained 17 % of the variation in Hb-AA. Intakes of coffee and biscuits/crackers were statistically significantly associated with a 3 % per 200 g/d (95 % CI 1, 6; P = 0·005) and 12 % per 10 g/d (95 % CI 3, 23; P = 0·01) higher Hb-GA, respectively. This model explained 12 % of the variation in Hb-GA. In conclusion, only a few dietary determinants of Hb-AA and Hb-GA were identified. Thus, the present study implies that dietary intake measured by an FFQ explains only to a limited extent the variation in Hb-AA and Hb-GA concentrations.</description><subject>Acrylamide</subject><subject>Acrylamide - chemistry</subject><subject>Acrylamide - metabolism</subject><subject>acrylamides</subject><subject>Biological and medical sciences</subject><subject>biscuits</subject><subject>Blood</subject><subject>Blood tests</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Carcinogens</subject><subject>Case-Control Studies</subject><subject>chemistry</subject><subject>Coffee</subject><subject>crackers</subject><subject>cross-sectional studies</subject><subject>Denmark</subject><subject>Diet</subject><subject>Dietary Surveys and Nutritional Epidemiology</subject><subject>Epoxy Compounds</subject><subject>Epoxy Compounds - chemistry</subject><subject>Epoxy Compounds - metabolism</subject><subject>erythrocytes</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>food intake</subject><subject>Foods and miscellaneous</subject><subject>Hemoglobins</subject><subject>Hemoglobins - chemistry</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>lifestyle</subject><subject>linear models</subject><subject>Liquid chromatography</subject><subject>Medical sciences</subject><subject>metabolism</subject><subject>Middle Aged</subject><subject>Postmenopause</subject><subject>questionnaires</subject><subject>regression analysis</subject><subject>Risk Factors</subject><subject>Smoking</subject><subject>Tumors</subject><subject>Women</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kM1u1TAQhS0EopfCA7CBCKkSm4DHju14WbWFIlViUbqsIsc_F5fELnYidN--jm7aSq1YeTzzzeicg9B7wF8Ag_h6iTEWAA2DUjCM6Qu0gUawmnBOXqLNMq6X-QF6k_NN-baA5Wt0QIAIQqXYoOtTbyeVdpWxk02jDypMuXIxVed9rXTaDWr0xlYqmKWzHXbam7VlzKwL7EN1qoLPv6sQQ53H-MeHbfUvjja8Ra-cGrJ9t76H6Orb2a-T8_ri5_cfJ8cXtWYYplpSIEbitlggxOHecgOS9EVs00sCjpjWOFcs9rZlUheLzhrGORNAseoZPUSf93dvU_w72zx1o8_aDoMKNs65A84pE7ShvKCfnqA3cU6hqOtazmTDqZAFgj2kU8w5WdfdJj-WmDrA3RJ99yz6svNhPTz3ozUPG_dZF-BoBVTWanBJBe3zI9cAFw0hhfu455yKndqmwlxdEgwNxsA4wGKXrvLU2CdvtvbRxP8F3gEx6aF3</recordid><startdate>20110514</startdate><enddate>20110514</enddate><creator>Outzen, Malene</creator><creator>Egeberg, Rikke</creator><creator>Dragsted, Lars</creator><creator>Christensen, Jane</creator><creator>Olesen, Pelle T.</creator><creator>Frandsen, Henrik</creator><creator>Overvad, Kim</creator><creator>Tjønneland, Anne</creator><creator>Olsen, Anja</creator><general>Cambridge University Press</general><general>CABI Pub</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20110514</creationdate><title>Dietary determinants for Hb-acrylamide and Hb-glycidamide adducts in Danish non-smoking women</title><author>Outzen, Malene ; Egeberg, Rikke ; Dragsted, Lars ; Christensen, Jane ; Olesen, Pelle T. ; Frandsen, Henrik ; Overvad, Kim ; Tjønneland, Anne ; Olsen, Anja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-9312d90850022f0be6d192b8104b921f2d8dff005be859c147fed56657130ab53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acrylamide</topic><topic>Acrylamide - chemistry</topic><topic>Acrylamide - metabolism</topic><topic>acrylamides</topic><topic>Biological and medical sciences</topic><topic>biscuits</topic><topic>Blood</topic><topic>Blood tests</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Carcinogens</topic><topic>Case-Control Studies</topic><topic>chemistry</topic><topic>Coffee</topic><topic>crackers</topic><topic>cross-sectional studies</topic><topic>Denmark</topic><topic>Diet</topic><topic>Dietary Surveys and Nutritional Epidemiology</topic><topic>Epoxy Compounds</topic><topic>Epoxy Compounds - chemistry</topic><topic>Epoxy Compounds - metabolism</topic><topic>erythrocytes</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>food intake</topic><topic>Foods and miscellaneous</topic><topic>Hemoglobins</topic><topic>Hemoglobins - chemistry</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>lifestyle</topic><topic>linear models</topic><topic>Liquid chromatography</topic><topic>Medical sciences</topic><topic>metabolism</topic><topic>Middle Aged</topic><topic>Postmenopause</topic><topic>questionnaires</topic><topic>regression analysis</topic><topic>Risk Factors</topic><topic>Smoking</topic><topic>Tumors</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Outzen, Malene</creatorcontrib><creatorcontrib>Egeberg, Rikke</creatorcontrib><creatorcontrib>Dragsted, Lars</creatorcontrib><creatorcontrib>Christensen, Jane</creatorcontrib><creatorcontrib>Olesen, Pelle T.</creatorcontrib><creatorcontrib>Frandsen, Henrik</creatorcontrib><creatorcontrib>Overvad, Kim</creatorcontrib><creatorcontrib>Tjønneland, Anne</creatorcontrib><creatorcontrib>Olsen, Anja</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Outzen, Malene</au><au>Egeberg, Rikke</au><au>Dragsted, Lars</au><au>Christensen, Jane</au><au>Olesen, Pelle T.</au><au>Frandsen, Henrik</au><au>Overvad, Kim</au><au>Tjønneland, Anne</au><au>Olsen, Anja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary determinants for Hb-acrylamide and Hb-glycidamide adducts in Danish non-smoking women</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2011-05-14</date><risdate>2011</risdate><volume>105</volume><issue>9</issue><spage>1381</spage><epage>1387</epage><pages>1381-1387</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Acrylamide (AA) is a probable human carcinogen that is formed in heat-treated carbohydrate-rich foods. The validity of FFQ to assess AA exposure has been questioned. The aim of the present cross-sectional study was to investigate dietary determinants of Hb-AA and Hb-glycidamide (GA) adducts. The study included 537 non-smoking women aged 50–65 years who participated in the Diet, Cancer and Health cohort (1993–97). At study baseline, blood samples and information on dietary and lifestyle variables obtained from self-administered questionnaires were collected. From blood samples, Hb-AA and Hb-GA in erythrocytes were analysed by liquid chromatography/MS/MS. Dietary determinants were evaluated by multiple linear regression analyses adjusted for age and smoking behaviour among ex-smokers. The median for Hb-AA was 35 pmol/g globin (5th percentile 17, 95th percentile 89) and for Hb-GA 21 pmol/g globin (5th percentile 8, 95th percentile 49). Of the dietary factors studied, intakes of coffee and chips were statistically significantly associated with a 4 % per 200 g/d (95 % CI 2, 7; P < 0·0001) and an 18 % per 5 g/d (95 % CI 6, 31; P = 0·002) higher Hb-AA, respectively. This model explained 17 % of the variation in Hb-AA. Intakes of coffee and biscuits/crackers were statistically significantly associated with a 3 % per 200 g/d (95 % CI 1, 6; P = 0·005) and 12 % per 10 g/d (95 % CI 3, 23; P = 0·01) higher Hb-GA, respectively. This model explained 12 % of the variation in Hb-GA. In conclusion, only a few dietary determinants of Hb-AA and Hb-GA were identified. Thus, the present study implies that dietary intake measured by an FFQ explains only to a limited extent the variation in Hb-AA and Hb-GA concentrations.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>21272397</pmid><doi>10.1017/S0007114510005003</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acrylamide Acrylamide - chemistry Acrylamide - metabolism acrylamides Biological and medical sciences biscuits Blood Blood tests Carcinogenesis, carcinogens and anticarcinogens Carcinogens Case-Control Studies chemistry Coffee crackers cross-sectional studies Denmark Diet Dietary Surveys and Nutritional Epidemiology Epoxy Compounds Epoxy Compounds - chemistry Epoxy Compounds - metabolism erythrocytes Feeding Behavior Female food intake Foods and miscellaneous Hemoglobins Hemoglobins - chemistry Hemoglobins - metabolism Humans lifestyle linear models Liquid chromatography Medical sciences metabolism Middle Aged Postmenopause questionnaires regression analysis Risk Factors Smoking Tumors Women |
| title | Dietary determinants for Hb-acrylamide and Hb-glycidamide adducts in Danish non-smoking women |
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