Prior Caspofungin Exposure in Patients with Hematological Malignancies Is a Risk Factor for Subsequent Fungemia Due to Decreased Susceptibility in Candida spp.: a Case-Control Study in Paris, France
Infections due to caspofungin-resistant Candida isolates in patients exposed to caspofungin therapy are increasing. We report here a nested case-control study which aimed at identifying factors associated with bloodstream infections caused by Candida spp. having reduced susceptibility to caspofungin...
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| Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2011-11, Vol.55 (11), p.5358-5361 |
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| container_title | Antimicrobial Agents and Chemotherapy |
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| creator | Blanchard, Elodie Lortholary, Olivier Boukris-Sitbon, Karine Desnos-Ollivier, Marie Dromer, Françoise Guillemot, Didier |
| description | Infections due to caspofungin-resistant Candida isolates in patients exposed to caspofungin therapy are increasing. We report here a nested case-control study which aimed at identifying factors associated with bloodstream infections caused by Candida spp. having reduced susceptibility to caspofungin (CRSC) in adults suffering from hematological malignancies. In univariate and multivariate analyses, infections with CRSC were associated with caspofungin exposure in the previous 30 days (odds ratio [OR] = 5.25; 95% confidence interval [95% CI], 1.68–16.35) and with an age of ≤65 years (OR = 3.27; 95% CI, 1.26–8.50). |
| doi_str_mv | 10.1128/AAC.00690-11 |
| format | Article |
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We report here a nested case-control study which aimed at identifying factors associated with bloodstream infections caused by Candida spp. having reduced susceptibility to caspofungin (CRSC) in adults suffering from hematological malignancies. In univariate and multivariate analyses, infections with CRSC were associated with caspofungin exposure in the previous 30 days (odds ratio [OR] = 5.25; 95% confidence interval [95% CI], 1.68–16.35) and with an age of ≤65 years (OR = 3.27; 95% CI, 1.26–8.50).</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.00690-11</identifier><identifier>PMID: 21859944</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>adults ; Aged ; antibiotic resistance ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal Agents ; Antifungal Agents - therapeutic use ; Biological and medical sciences ; blood flow ; Candida ; Candida - drug effects ; Candida - pathogenicity ; Case-Control Studies ; Clinical Therapeutics ; confidence interval ; drug effects ; Drug Resistance, Fungal ; drug therapy ; Echinocandins ; Echinocandins - therapeutic use ; Female ; France ; Fungemia ; Fungemia - drug therapy ; Hematologic Neoplasms ; Hematologic Neoplasms - drug therapy ; Hematologic Neoplasms - microbiology ; Human mycoses ; Humans ; Infectious diseases ; Life Sciences ; Lipopeptides ; Male ; Medical sciences ; microbiology ; Microbiology and Parasitology ; Middle Aged ; multivariate analysis ; Mycology ; Mycoses ; Mycotic sepsis ; odds ratio ; pathogenicity ; patients ; Pharmacology. Drug treatments ; Risk Factors ; therapeutic use ; therapeutics</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2011-11, Vol.55 (11), p.5358-5361</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011, American Society for Microbiology. All Rights Reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2011, American Society for Microbiology. All Rights Reserved. 2011 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a565t-aca5634985e43333b2aefb2a001c71a3fc9576dec14b2fe1030ee021364a5ccc3</citedby><cites>FETCH-LOGICAL-a565t-aca5634985e43333b2aefb2a001c71a3fc9576dec14b2fe1030ee021364a5ccc3</cites><orcidid>0000-0003-1671-1475 ; 0000-0002-8497-1765 ; 0000-0002-9137-0466</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194997/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194997/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24692886$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21859944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00818510$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Blanchard, Elodie</creatorcontrib><creatorcontrib>Lortholary, Olivier</creatorcontrib><creatorcontrib>Boukris-Sitbon, Karine</creatorcontrib><creatorcontrib>Desnos-Ollivier, Marie</creatorcontrib><creatorcontrib>Dromer, Françoise</creatorcontrib><creatorcontrib>Guillemot, Didier</creatorcontrib><creatorcontrib>French Mycosis Study Group</creatorcontrib><creatorcontrib>the French Mycosis Study Group</creatorcontrib><title>Prior Caspofungin Exposure in Patients with Hematological Malignancies Is a Risk Factor for Subsequent Fungemia Due to Decreased Susceptibility in Candida spp.: a Case-Control Study in Paris, France</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Infections due to caspofungin-resistant Candida isolates in patients exposed to caspofungin therapy are increasing. We report here a nested case-control study which aimed at identifying factors associated with bloodstream infections caused by Candida spp. having reduced susceptibility to caspofungin (CRSC) in adults suffering from hematological malignancies. In univariate and multivariate analyses, infections with CRSC were associated with caspofungin exposure in the previous 30 days (odds ratio [OR] = 5.25; 95% confidence interval [95% CI], 1.68–16.35) and with an age of ≤65 years (OR = 3.27; 95% CI, 1.26–8.50).</description><subject>adults</subject><subject>Aged</subject><subject>antibiotic resistance</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal Agents</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>blood flow</subject><subject>Candida</subject><subject>Candida - drug effects</subject><subject>Candida - pathogenicity</subject><subject>Case-Control Studies</subject><subject>Clinical Therapeutics</subject><subject>confidence interval</subject><subject>drug effects</subject><subject>Drug Resistance, Fungal</subject><subject>drug therapy</subject><subject>Echinocandins</subject><subject>Echinocandins - therapeutic use</subject><subject>Female</subject><subject>France</subject><subject>Fungemia</subject><subject>Fungemia - drug therapy</subject><subject>Hematologic Neoplasms</subject><subject>Hematologic Neoplasms - drug therapy</subject><subject>Hematologic Neoplasms - microbiology</subject><subject>Human mycoses</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Life Sciences</subject><subject>Lipopeptides</subject><subject>Male</subject><subject>Medical sciences</subject><subject>microbiology</subject><subject>Microbiology and Parasitology</subject><subject>Middle Aged</subject><subject>multivariate analysis</subject><subject>Mycology</subject><subject>Mycoses</subject><subject>Mycotic sepsis</subject><subject>odds ratio</subject><subject>pathogenicity</subject><subject>patients</subject><subject>Pharmacology. 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Antiinfectious agents. 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We report here a nested case-control study which aimed at identifying factors associated with bloodstream infections caused by Candida spp. having reduced susceptibility to caspofungin (CRSC) in adults suffering from hematological malignancies. In univariate and multivariate analyses, infections with CRSC were associated with caspofungin exposure in the previous 30 days (odds ratio [OR] = 5.25; 95% confidence interval [95% CI], 1.68–16.35) and with an age of ≤65 years (OR = 3.27; 95% CI, 1.26–8.50).</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>21859944</pmid><doi>10.1128/AAC.00690-11</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-1671-1475</orcidid><orcidid>https://orcid.org/0000-0002-8497-1765</orcidid><orcidid>https://orcid.org/0000-0002-9137-0466</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | adults Aged antibiotic resistance Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents Antifungal Agents - therapeutic use Biological and medical sciences blood flow Candida Candida - drug effects Candida - pathogenicity Case-Control Studies Clinical Therapeutics confidence interval drug effects Drug Resistance, Fungal drug therapy Echinocandins Echinocandins - therapeutic use Female France Fungemia Fungemia - drug therapy Hematologic Neoplasms Hematologic Neoplasms - drug therapy Hematologic Neoplasms - microbiology Human mycoses Humans Infectious diseases Life Sciences Lipopeptides Male Medical sciences microbiology Microbiology and Parasitology Middle Aged multivariate analysis Mycology Mycoses Mycotic sepsis odds ratio pathogenicity patients Pharmacology. Drug treatments Risk Factors therapeutic use therapeutics |
| title | Prior Caspofungin Exposure in Patients with Hematological Malignancies Is a Risk Factor for Subsequent Fungemia Due to Decreased Susceptibility in Candida spp.: a Case-Control Study in Paris, France |
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