Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter

Presynaptic nerve terminals are formed from preassembled vesicles that are delivered to the prospective synapse by kinesin-mediated axonal transport. However, precisely how the various cargoes are linked to the motor proteins remains unclear. Here, we report a transport complex linking syntaxin 1a (...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-04, Vol.109 (15), p.5862-5867
Hauptverfasser:	Chua, John Jia En, Butkevich, Eugenia, Worseck, Josephine M, Kittelmann, Maike, Grønborg, Mads, Behrmann, Elmar, Stelzl, Ulrich, Pavlos, Nathan J, Lalowski, Maciej M, Eimer, Stefan, Wanker, Erich E, Klopfenstein, Dieter Robert, Jahn, Reinhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adaptor Proteins, Signal Transducing - metabolism Amino acids Animals Antibodies Axonal Transport Axons Axons - metabolism Binding sites Biological Sciences Caenorhabditis elegans Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins Caenorhabditis elegans Proteins - metabolism Cell membranes cytoplasmic streaming exocytosis Freight genetics HEK293 Cells Humans kinesin Kinesin - metabolism Kinesins metabolism molecular motor proteins Munc18 Proteins Munc18 Proteins - metabolism Mutant Proteins Mutant Proteins - metabolism Mutation Mutation - genetics Nematodes nerve tissue Nerve Tissue Proteins Nerve Tissue Proteins - metabolism Neurons Neuropeptides Neuropeptides - metabolism Neurosecretory cells PC12 cells Phosphorylation plasma membrane Protein Binding protein kinases Protein Transport Proteins serine synapse Syntaxin 1 Syntaxin 1 - metabolism
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