A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle

Abstract The role of non-structural protein 3A of foot-and-mouth disease virus (FMDV) on the virulence in cattle has received significant attention. Particularly, a characteristic 10–20 amino acid deletion has been implicated as responsible for virus attenuation in cattle: a 10 amino acid deletion i...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2013-11, Vol.446 (1), p.260-267
Hauptverfasser:	Pacheco, Juan M, Gladue, Douglas P, Holinka, Lauren G, Arzt, Jonathan, Bishop, Elizabeth, Smoliga, George, Pauszek, Steve J, Bracht, Alexa J, O'Donnell, Vivian, Fernandez-Sainz, Ignacio, Fletcher, Paige, Piccone, Maria E, Rodriguez, Luis L, Borca, Manuel V
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid deletion Amino Acid Sequence Animals Cattle Cattle Diseases - pathology Cattle Diseases - virology Foot-and-Mouth Disease - pathology Foot-and-Mouth Disease - virology Foot-and-mouth disease virus Foot-and-Mouth Disease Virus - genetics Foot-and-Mouth Disease Virus - pathogenicity Infectious Disease Molecular Sequence Data Nasal Mucosa - virology phenotype Sequence Alignment Sequence Deletion serotypes Serum - virology Viral Load Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Viral Plaque Assay viral proteins Virulence Virulence Factors - genetics Virulence Factors - metabolism viruses
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