Nitric Oxide is an Important Mediator for Tumoricidal Activity In vivo

When cultured in vitro, peritoneal macrophages, obtained from mice previously inoculated with bacillus Calmette-Guérin, release nitric oxide, which is cytostatic and/or cytolytic for tumor cells. However, it is not known whether nitric oxide has antitumor effects in vivo. Here we demonstrate that ni...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-09, Vol.91 (20), p.9407-9411
Hauptverfasser:	Farias-Eisner, Robin, Sherman, Michael P., Aeberhard, Ernesto, Chaudhuri, Gautam
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - pharmacology Arginine - analogs & derivatives Arginine - pharmacology Cancer Cell Line Cell lines Cell Survival - drug effects Cell transplantation Cytokines Cytokines - pharmacology Epithelial cells Female Humans Immunity, Innate Interferon-gamma - immunology Interferon-gamma - pharmacology Interferon-gamma - physiology Lipopolysaccharides - pharmacology Lymphocytes Macrophages Medical research Mice Mice, Inbred C3H Mice, Nude Mycobacterium bovis - immunology Nitric Oxide - physiology omega-N-Methylarginine Ovarian Neoplasms - immunology Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Pharmacology Reproductive system Rodents Teratocarcinoma Tissue grafting Transplantation, Heterologous Tumor cell line Tumor Cells, Cultured Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - physiology Tumors
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