The Peroxisome Proliferator-Activated Receptor Regulates Mitochondrial Fatty Acid Oxidative Enzyme Gene Expression

Medium-chain acyl-CoA dehydrogenase (MCAD) catalyzes a pivotal reaction in mitochondrial fatty acid (FA) β-oxidation. To examine the potential role of FAs and their metabolites in the regulation of MCAD gene expression, we measured MCAD mRNA levels in animals fed inhibitors of mitochondrial long-cha...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-11, Vol.91 (23), p.11012-11016
Hauptverfasser:	Gulick, Tod, Cresci, Sharon, Caira, Teresa, Moore, David D., Kelly, Daniel P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA Dehydrogenase Acyl-CoA Dehydrogenase, Long-Chain - genetics Animals Base Sequence Biochemistry Carnitine O-Palmitoyltransferase - antagonists & inhibitors Enzymes Fatty acids Fatty Acids - metabolism Gene expression regulation Gene Expression Regulation, Enzymologic Genes Hep G2 cells Lipid metabolism Male Messenger RNA Metabolism Mitochondria - enzymology Molecular Sequence Data Oxidation Plasmids Promoter Regions, Genetic Rats Rats, Sprague-Dawley Receptors Receptors, Cytoplasmic and Nuclear - physiology Ribonucleic acid RNA RNA, Messenger - genetics Tissue Distribution Transcription Factors - physiology Transcription, Genetic Transcriptional Activation
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