Weaning Triggers a Maturation Step of Pancreatic β Cells

Because tissue regeneration deteriorates with age, it is generally assumed that the younger the animal, the better it compensates for tissue damage. We have examined the effect of young age on compensatory proliferation of pancreatic β cells in vivo. Surprisingly, β cells in suckling mice fail to en...

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Veröffentlicht in:	Developmental cell 2015-03, Vol.32 (5), p.535-545
Hauptverfasser:	Stolovich-Rain, Miri, Enk, Jonatan, Vikesa, Jonas, Nielsen, Finn Cilius, Saada, Ann, Glaser, Benjamin, Dor, Yuval
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomarkers - metabolism Blotting, Western Cell Proliferation Cells, Cultured Female Gene Expression Profiling Glucose - pharmacology Hypoglycemic Agents - pharmacology Immunoenzyme Techniques Insulin - pharmacology Insulin-Secreting Cells - cytology Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Islets of Langerhans - cytology Islets of Langerhans - drug effects Islets of Langerhans - metabolism Male Mice Mice, Inbred ICR Mice, Transgenic Oligonucleotide Array Sequence Analysis Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Weaning
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