MicroRNA-7 expression in colorectal cancer is associated with poor prognosis and regulates cetuximab sensitivity via EGFR regulation

MicroRNA-7 (miR-7) has been reported to be a tumor suppressor in all malignancies including colorectal cancer (CRC). However, its significance for CRC clinical outcomes has not yet been explored. The potential for miR-7 to act as a tumor suppressor by coordinately regulating the epidermal growth fac...

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Veröffentlicht in:	Carcinogenesis (New York) 2015-03, Vol.36 (3), p.338-345
Hauptverfasser:	Suto, Toshinaga, Yokobori, Takehiko, Yajima, Reina, Morita, Hiroki, Fujii, Takaaki, Yamaguchi, Satoru, Altan, Bolag, Tsutsumi, Souichi, Asao, Takayuki, Kuwano, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Antibodies, Monoclonal, Humanized - pharmacology Biomarkers, Tumor - genetics Cell Line, Tumor Cell Proliferation - genetics Cetuximab Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Drug Resistance, Neoplasm - genetics Female Gene Expression Regulation, Neoplastic Humans Male MicroRNAs - genetics Middle Aged Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Prognosis Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-raf - genetics Proto-Oncogene Proteins c-raf - metabolism Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism
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