B(12)-mediated, long wavelength photopolymerization of hydrogels
Medical hydrogel applications have expanded rapidly over the past decade. Implantation in patients by noninvasive injection is preferred, but this requires hydrogel solidification from a low viscosity solution to occur in vivo via an applied stimuli. Transdermal photo-cross-linking of acrylated biop...
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| Veröffentlicht in: | Journal of the American Chemical Society 2015-03, Vol.137 (9), p.3372-3378 |
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| container_issue | 9 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 137 |
| creator | Rodgers, Zachary L Hughes, Robert M Doherty, Laura M Shell, Jennifer R Molesky, Brian P Brugh, Alexander M Forbes, Malcolm D E Moran, Andrew M Lawrence, David S |
| description | Medical hydrogel applications have expanded rapidly over the past decade. Implantation in patients by noninvasive injection is preferred, but this requires hydrogel solidification from a low viscosity solution to occur in vivo via an applied stimuli. Transdermal photo-cross-linking of acrylated biopolymers with photoinitiators and lights offers a mild, spatiotemporally controlled solidification trigger. However, the current short wavelength initiators limit curing depth and efficacy because they do not absorb within the optical window of tissue (600-900 nm). As a solution to the current wavelength limitations, we report the development of a red light responsive initiator capable of polymerizing a range of acrylated monomers. Photoactivation occurs within a range of skin type models containing high biochromophore concentrations. |
| doi_str_mv | 10.1021/jacs.5b00182 |
| format | Article |
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Implantation in patients by noninvasive injection is preferred, but this requires hydrogel solidification from a low viscosity solution to occur in vivo via an applied stimuli. Transdermal photo-cross-linking of acrylated biopolymers with photoinitiators and lights offers a mild, spatiotemporally controlled solidification trigger. However, the current short wavelength initiators limit curing depth and efficacy because they do not absorb within the optical window of tissue (600-900 nm). As a solution to the current wavelength limitations, we report the development of a red light responsive initiator capable of polymerizing a range of acrylated monomers. 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Implantation in patients by noninvasive injection is preferred, but this requires hydrogel solidification from a low viscosity solution to occur in vivo via an applied stimuli. Transdermal photo-cross-linking of acrylated biopolymers with photoinitiators and lights offers a mild, spatiotemporally controlled solidification trigger. However, the current short wavelength initiators limit curing depth and efficacy because they do not absorb within the optical window of tissue (600-900 nm). As a solution to the current wavelength limitations, we report the development of a red light responsive initiator capable of polymerizing a range of acrylated monomers. 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| fulltext | fulltext |
| identifier | EISSN: 1520-5126 |
| ispartof | Journal of the American Chemical Society, 2015-03, Vol.137 (9), p.3372-3378 |
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| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Acrylates - chemistry Cell Survival Hep G2 Cells Humans Hydrogels - chemistry Light Materials Testing - methods Melanins - chemistry Photochemistry - methods Photolysis Polyethylene Glycols - chemistry Polymerization Propane - analogs & derivatives Propane - chemistry Skin Vitamin B 12 - chemistry |
| title | B(12)-mediated, long wavelength photopolymerization of hydrogels |
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