Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

Significance Antiretroviral therapy (ART) effectively suppresses HIV replication; however, treatment cannot be stopped, because latently infected CD4+ T cells will rekindle infection. As one estimate of the size of the pool of latently infected cells that must be purged for cure, we asked whether re...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-03, Vol.112 (10), p.E1126-E1134
Hauptverfasser:	Rothenberger, Meghan K., Keele, Brandon F., Wietgrefe, Stephen W., Fletcher, Courtney V., Beilman, Gregory J., Chipman, Jeffrey G., Khoruts, Alexander, Estes, Jacob D., Anderson, Jodi, Callisto, Samuel P., Schmidt, Thomas E., Thorkelson, Ann, Reilly, Cavan, Perkey, Katherine, Reimann, Thomas G., Utay, Netanya S., Makamdop, Krystelle Nganou, Stevenson, Mario, Douek, Daniel C., Haase, Ashley T., Schacker, Timothy W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - therapeutic use antiretroviral agents Antiretroviral drugs Biological Sciences CD4 Lymphocyte Count CD4-positive T-lymphocytes Cells Drug Administration Schedule Drug therapy HIV HIV - genetics HIV - physiology HIV infections HIV Infections - drug therapy HIV Infections - virology Human immunodeficiency virus Humans In Situ Hybridization Lymphatic system Lymphoid Tissue - virology Middle Aged Molecular Sequence Data patients Phylogeny PNAS Plus RNA, Viral - blood therapeutics Tissues Viral Load viruses
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