Anti‐fibrotic and Anti‐tumorigenic Effects of Rhein, a Natural Anthraquinone Derivative, in Mammalian Stellate and Carcinoma Cells

Anthraquinone compounds have been recognized to possess antiinflammatory, anti‐fibrotic and anti‐tumour properties and thus applied in human and veterinary therapeutics as active substances of medicinal products. Amongst the anthraquinones isolated from Rheum palmatum, also known as da‐huang, rhein...

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Veröffentlicht in:	Phytotherapy research 2015-03, Vol.29 (3), p.407-414
Hauptverfasser:	Tsang, Siu Wai, Bian, Zhao‐Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Actins - metabolism active ingredients adenocarcinoma Animals anthraquinone anthraquinones Anthraquinones - pharmacology anti-fibrotic agent anti-inflammatory activity anti-tumour agent Antineoplastic Agents, Phytogenic - pharmacology blood flow Cadherins - metabolism carcinoma cells Cell Line, Tumor collagen Collagen Type I - metabolism fibronectins Fibronectins - metabolism Hedgehog Proteins - metabolism Humans Matrix Metalloproteinases - metabolism messenger RNA metabolites metalloproteinases muscles Pancreatic Stellate Cells - drug effects Protein-Serine-Threonine Kinases - metabolism quantitative polymerase chain reaction Rats rhein Rheum - chemistry Rheum palmatum signal transduction Signal Transduction - drug effects stellate cells therapeutics Western blotting
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