Influence of Trans Fat on Skin Damage in First-Generation Rats Exposed to UV Radiation
The influence of trans fatty acids (TFA) on lipid profile, oxidative damage and mitochondrial function in the skin of rats exposed to ultraviolet radiation (UVR) was assessed. The first‐generation offspring of female Wistar rats supplemented from pregnancy with either soybean oil (C‐SO, rich in n–6...
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| Veröffentlicht in: | Photochemistry and photobiology 2015-03, Vol.91 (2), p.424-430 |
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| creator | Barcelos, Raquel Cristine S. Vey, Luciana T. Segat, Hecson Jesser Benvegnú, Dalila M. Trevizol, Fabíola Roversi, Karine Roversi, Katiane Dias, Verônica T. Dolci, Geisa S. Kuhn, Fábio T. Piccolo, Jaqueline CristinaVeit, Juliana Emanuelli, Tatiana Bürger, Marilise E. |
| description | The influence of trans fatty acids (TFA) on lipid profile, oxidative damage and mitochondrial function in the skin of rats exposed to ultraviolet radiation (UVR) was assessed. The first‐generation offspring of female Wistar rats supplemented from pregnancy with either soybean oil (C‐SO, rich in n–6 FA; control group) or hydrogenated vegetable fat (HVF, rich in TFA) were continued with the same supplements until adulthood, when half of each group was exposed to UVR for 12 weeks. The HVF group showed higher TFA cutaneous incorporation, increased protein carbonyl (PC) levels, decreased functionality of mitochondrial enzymes and antioxidant defenses of the skin. After UVR, the HVF group showed increased skin thickness and reactive species (RS) generation, with decreased skin antioxidant defenses. RS generation was positively correlated with skin thickness, wrinkles and PC levels. Once incorporated to skin, TFA make it more susceptible to developing UVR‐induced disorders.
Metabolism of trans fat by COX and LOX: The dietary intake of trans fat favors the synthesis of biologically active prostanoids produced during inflammatory processes. After ultraviolet radiation exposure, trans fat supplementation, which is rich in trans fatty acids (TFA), increases the skin thickness, reactive species generation and decreases the skin antioxidant defenses. |
| doi_str_mv | 10.1111/php.12414 |
| format | Article |
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Metabolism of trans fat by COX and LOX: The dietary intake of trans fat favors the synthesis of biologically active prostanoids produced during inflammatory processes. After ultraviolet radiation exposure, trans fat supplementation, which is rich in trans fatty acids (TFA), increases the skin thickness, reactive species generation and decreases the skin antioxidant defenses.</description><identifier>ISSN: 0031-8655</identifier><identifier>EISSN: 1751-1097</identifier><identifier>DOI: 10.1111/php.12414</identifier><identifier>PMID: 25600099</identifier><identifier>CODEN: PHCBAP</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; Antioxidants ; Antioxidants - metabolism ; Catalase - metabolism ; Dietary Supplements ; Enzymes ; Female ; Hydrogenation ; Lipids ; Mitochondria ; Mitochondria - drug effects ; Mitochondria - radiation effects ; Plant Oils - administration & dosage ; Pregnancy ; Protein Carbonylation - drug effects ; Protein Carbonylation - radiation effects ; Rats ; Rats, Wistar ; Reactive Oxygen Species - metabolism ; Skin - chemistry ; Skin - drug effects ; Skin - metabolism ; Skin - radiation effects ; Skin Aging - drug effects ; Skin Aging - radiation effects ; Soybean Oil - administration & dosage ; Superoxide Dismutase - metabolism ; Trans fats ; Ultraviolet radiation ; Ultraviolet Rays ; Vegetable oils</subject><ispartof>Photochemistry and photobiology, 2015-03, Vol.91 (2), p.424-430</ispartof><rights>2015 The American Society of Photobiology</rights><rights>2015 The American Society of Photobiology.</rights><rights>Copyright Blackwell Publishing Ltd. Mar-Apr 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4614-3ee82f15860ad9b99cd280c12ea17463aa5bae5aae1d980a06a68f1acaba9e373</citedby><cites>FETCH-LOGICAL-c4614-3ee82f15860ad9b99cd280c12ea17463aa5bae5aae1d980a06a68f1acaba9e373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fphp.12414$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fphp.12414$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25600099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barcelos, Raquel Cristine S.</creatorcontrib><creatorcontrib>Vey, Luciana T.</creatorcontrib><creatorcontrib>Segat, Hecson Jesser</creatorcontrib><creatorcontrib>Benvegnú, Dalila M.</creatorcontrib><creatorcontrib>Trevizol, Fabíola</creatorcontrib><creatorcontrib>Roversi, Karine</creatorcontrib><creatorcontrib>Roversi, Katiane</creatorcontrib><creatorcontrib>Dias, Verônica T.</creatorcontrib><creatorcontrib>Dolci, Geisa S.</creatorcontrib><creatorcontrib>Kuhn, Fábio T.</creatorcontrib><creatorcontrib>Piccolo, Jaqueline</creatorcontrib><creatorcontrib>CristinaVeit, Juliana</creatorcontrib><creatorcontrib>Emanuelli, Tatiana</creatorcontrib><creatorcontrib>Bürger, Marilise E.</creatorcontrib><title>Influence of Trans Fat on Skin Damage in First-Generation Rats Exposed to UV Radiation</title><title>Photochemistry and photobiology</title><addtitle>Photochem Photobiol</addtitle><description>The influence of trans fatty acids (TFA) on lipid profile, oxidative damage and mitochondrial function in the skin of rats exposed to ultraviolet radiation (UVR) was assessed. The first‐generation offspring of female Wistar rats supplemented from pregnancy with either soybean oil (C‐SO, rich in n–6 FA; control group) or hydrogenated vegetable fat (HVF, rich in TFA) were continued with the same supplements until adulthood, when half of each group was exposed to UVR for 12 weeks. The HVF group showed higher TFA cutaneous incorporation, increased protein carbonyl (PC) levels, decreased functionality of mitochondrial enzymes and antioxidant defenses of the skin. After UVR, the HVF group showed increased skin thickness and reactive species (RS) generation, with decreased skin antioxidant defenses. RS generation was positively correlated with skin thickness, wrinkles and PC levels. Once incorporated to skin, TFA make it more susceptible to developing UVR‐induced disorders.
Metabolism of trans fat by COX and LOX: The dietary intake of trans fat favors the synthesis of biologically active prostanoids produced during inflammatory processes. After ultraviolet radiation exposure, trans fat supplementation, which is rich in trans fatty acids (TFA), increases the skin thickness, reactive species generation and decreases the skin antioxidant defenses.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Catalase - metabolism</subject><subject>Dietary Supplements</subject><subject>Enzymes</subject><subject>Female</subject><subject>Hydrogenation</subject><subject>Lipids</subject><subject>Mitochondria</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - radiation effects</subject><subject>Plant Oils - administration & dosage</subject><subject>Pregnancy</subject><subject>Protein Carbonylation - drug effects</subject><subject>Protein Carbonylation - radiation effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Skin - chemistry</subject><subject>Skin - drug effects</subject><subject>Skin - metabolism</subject><subject>Skin - radiation effects</subject><subject>Skin Aging - drug effects</subject><subject>Skin Aging - radiation effects</subject><subject>Soybean Oil - administration & dosage</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Trans fats</subject><subject>Ultraviolet radiation</subject><subject>Ultraviolet Rays</subject><subject>Vegetable oils</subject><issn>0031-8655</issn><issn>1751-1097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9PFEEQxTtGIyt68AuYTrzoYaBr-s90Hw3LLhiiRBb01qmdqdGB2ZmxeybAt6dhgYOJdalKvV-9VB5j70HsQar94c-wB7kC9YLNoNCQgXDFSzYTQkJmjdY77E2Ml0KAcgW8Zju5NkII52bs4rir24m6knhf81XALvIFjrzv-NlV0_E5bvA38TQtmhDHbEkdBRybpP_AMfLDm6GPVPGx5-cXaVU1D-Jb9qrGNtK7x77LzheHq4Oj7OT78vjgy0lWKgMqk0Q2r0FbI7Bya-fKKreihJwQCmUkol4jaUSCylmBwqCxNWCJa3QkC7nLPm19h9D_nSiOftPEktoWO-qn6MGYXEmwuU3ox3_Qy34KXfrunpKFkUrJRH3eUmXoYwxU-yE0Gwy3HoS_D9unsP1D2In98Og4rTdUPZNP6SZgfwtcNy3d_t_Jnx6dPllm24smjnTzfIHhyptCFtr__Lb0X-erpT6zv_xc3gGC4JY2</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Barcelos, Raquel Cristine S.</creator><creator>Vey, Luciana T.</creator><creator>Segat, Hecson Jesser</creator><creator>Benvegnú, Dalila M.</creator><creator>Trevizol, Fabíola</creator><creator>Roversi, Karine</creator><creator>Roversi, Katiane</creator><creator>Dias, Verônica T.</creator><creator>Dolci, Geisa S.</creator><creator>Kuhn, Fábio T.</creator><creator>Piccolo, Jaqueline</creator><creator>CristinaVeit, Juliana</creator><creator>Emanuelli, Tatiana</creator><creator>Bürger, Marilise E.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>7TM</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201503</creationdate><title>Influence of Trans Fat on Skin Damage in First-Generation Rats Exposed to UV Radiation</title><author>Barcelos, Raquel Cristine S. ; Vey, Luciana T. ; Segat, Hecson Jesser ; Benvegnú, Dalila M. ; Trevizol, Fabíola ; Roversi, Karine ; Roversi, Katiane ; Dias, Verônica T. ; Dolci, Geisa S. ; Kuhn, Fábio T. ; Piccolo, Jaqueline ; CristinaVeit, Juliana ; Emanuelli, Tatiana ; Bürger, Marilise E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4614-3ee82f15860ad9b99cd280c12ea17463aa5bae5aae1d980a06a68f1acaba9e373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Catalase - metabolism</topic><topic>Dietary Supplements</topic><topic>Enzymes</topic><topic>Female</topic><topic>Hydrogenation</topic><topic>Lipids</topic><topic>Mitochondria</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - radiation effects</topic><topic>Plant Oils - administration & dosage</topic><topic>Pregnancy</topic><topic>Protein Carbonylation - drug effects</topic><topic>Protein Carbonylation - radiation effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Skin - chemistry</topic><topic>Skin - drug effects</topic><topic>Skin - metabolism</topic><topic>Skin - radiation effects</topic><topic>Skin Aging - drug effects</topic><topic>Skin Aging - radiation effects</topic><topic>Soybean Oil - administration & dosage</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Trans fats</topic><topic>Ultraviolet radiation</topic><topic>Ultraviolet Rays</topic><topic>Vegetable oils</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barcelos, Raquel Cristine S.</creatorcontrib><creatorcontrib>Vey, Luciana T.</creatorcontrib><creatorcontrib>Segat, Hecson Jesser</creatorcontrib><creatorcontrib>Benvegnú, Dalila M.</creatorcontrib><creatorcontrib>Trevizol, Fabíola</creatorcontrib><creatorcontrib>Roversi, Karine</creatorcontrib><creatorcontrib>Roversi, Katiane</creatorcontrib><creatorcontrib>Dias, Verônica T.</creatorcontrib><creatorcontrib>Dolci, Geisa S.</creatorcontrib><creatorcontrib>Kuhn, Fábio T.</creatorcontrib><creatorcontrib>Piccolo, Jaqueline</creatorcontrib><creatorcontrib>CristinaVeit, Juliana</creatorcontrib><creatorcontrib>Emanuelli, Tatiana</creatorcontrib><creatorcontrib>Bürger, Marilise E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Photochemistry and photobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barcelos, Raquel Cristine S.</au><au>Vey, Luciana T.</au><au>Segat, Hecson Jesser</au><au>Benvegnú, Dalila M.</au><au>Trevizol, Fabíola</au><au>Roversi, Karine</au><au>Roversi, Katiane</au><au>Dias, Verônica T.</au><au>Dolci, Geisa S.</au><au>Kuhn, Fábio T.</au><au>Piccolo, Jaqueline</au><au>CristinaVeit, Juliana</au><au>Emanuelli, Tatiana</au><au>Bürger, Marilise E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Trans Fat on Skin Damage in First-Generation Rats Exposed to UV Radiation</atitle><jtitle>Photochemistry and photobiology</jtitle><addtitle>Photochem Photobiol</addtitle><date>2015-03</date><risdate>2015</risdate><volume>91</volume><issue>2</issue><spage>424</spage><epage>430</epage><pages>424-430</pages><issn>0031-8655</issn><eissn>1751-1097</eissn><coden>PHCBAP</coden><abstract>The influence of trans fatty acids (TFA) on lipid profile, oxidative damage and mitochondrial function in the skin of rats exposed to ultraviolet radiation (UVR) was assessed. The first‐generation offspring of female Wistar rats supplemented from pregnancy with either soybean oil (C‐SO, rich in n–6 FA; control group) or hydrogenated vegetable fat (HVF, rich in TFA) were continued with the same supplements until adulthood, when half of each group was exposed to UVR for 12 weeks. The HVF group showed higher TFA cutaneous incorporation, increased protein carbonyl (PC) levels, decreased functionality of mitochondrial enzymes and antioxidant defenses of the skin. After UVR, the HVF group showed increased skin thickness and reactive species (RS) generation, with decreased skin antioxidant defenses. RS generation was positively correlated with skin thickness, wrinkles and PC levels. Once incorporated to skin, TFA make it more susceptible to developing UVR‐induced disorders.
Metabolism of trans fat by COX and LOX: The dietary intake of trans fat favors the synthesis of biologically active prostanoids produced during inflammatory processes. After ultraviolet radiation exposure, trans fat supplementation, which is rich in trans fatty acids (TFA), increases the skin thickness, reactive species generation and decreases the skin antioxidant defenses.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25600099</pmid><doi>10.1111/php.12414</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antioxidants Antioxidants - metabolism Catalase - metabolism Dietary Supplements Enzymes Female Hydrogenation Lipids Mitochondria Mitochondria - drug effects Mitochondria - radiation effects Plant Oils - administration & dosage Pregnancy Protein Carbonylation - drug effects Protein Carbonylation - radiation effects Rats Rats, Wistar Reactive Oxygen Species - metabolism Skin - chemistry Skin - drug effects Skin - metabolism Skin - radiation effects Skin Aging - drug effects Skin Aging - radiation effects Soybean Oil - administration & dosage Superoxide Dismutase - metabolism Trans fats Ultraviolet radiation Ultraviolet Rays Vegetable oils |
| title | Influence of Trans Fat on Skin Damage in First-Generation Rats Exposed to UV Radiation |
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