A high dose of short term exogenous d-galactose administration in young male rats produces symptoms simulating the natural aging process
d-Galactose (d-gal) induced accelerated senescence has been used to develop an aging model for brain. Previously, long term administration of a wide range of doses has been used for this purpose. In the present study we investigate whether short term administration of a high dose of d-gal in rats in...
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| Veröffentlicht in: | Life sciences (1973) 2015-03, Vol.124, p.110-119 |
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| container_title | Life sciences (1973) |
| container_volume | 124 |
| creator | Haider, Saida Liaquat, Laraib Shahzad, Sidrah Sadir, Sadia Madiha, Syeda Batool, Zehra Tabassum, Saiqa Saleem, Sadia Naqvi, Fizza Perveen, Tahira |
| description | d-Galactose (d-gal) induced accelerated senescence has been used to develop an aging model for brain. Previously, long term administration of a wide range of doses has been used for this purpose. In the present study we investigate whether short term administration of a high dose of d-gal in rats induces significant signs and symptoms similar to natural aging.
Young rats were injected intraperitoneally with d-gal at a dose of 300mg/ml/kg for one week. Behavioral analysis for depression and anxiety like symptoms were monitored by forced swim test (FST) and light/dark transition (LDT) test. Assessment of memory was done using the Morris water maze (MWM), passive avoidance test (PAT) and elevated plus maze (EPM) test. Biochemical analysis was done for estimation of antioxidant enzymes and acetylcholinesterase. Determination of brain biogenic amines was performed by HPLC–EC.
Short term administration of d-gal significantly altered behavioral, biochemical and neurochemical responses in rats. d-Gal injected rats exhibited depressogenic and anxiogenic behaviors while memory was also significantly impaired in these rats. Brain lipid peroxidation and superoxide dismutase activity were significantly increased while catalase and glutathione peroxidase decreased. Increased activity of acetylcholinesterase was also exhibited by d-gal injected rats while brain biogenic amines were significantly decreased. Food intake and growth rate were however comparable in both groups.
Together the behavioral, biochemical and neurochemical impairments following the high dose of d-gal suggest that symptoms similar to natural aging may be developed in rats in as early as one week. |
| doi_str_mv | 10.1016/j.lfs.2015.01.016 |
| format | Article |
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Young rats were injected intraperitoneally with d-gal at a dose of 300mg/ml/kg for one week. Behavioral analysis for depression and anxiety like symptoms were monitored by forced swim test (FST) and light/dark transition (LDT) test. Assessment of memory was done using the Morris water maze (MWM), passive avoidance test (PAT) and elevated plus maze (EPM) test. Biochemical analysis was done for estimation of antioxidant enzymes and acetylcholinesterase. Determination of brain biogenic amines was performed by HPLC–EC.
Short term administration of d-gal significantly altered behavioral, biochemical and neurochemical responses in rats. d-Gal injected rats exhibited depressogenic and anxiogenic behaviors while memory was also significantly impaired in these rats. Brain lipid peroxidation and superoxide dismutase activity were significantly increased while catalase and glutathione peroxidase decreased. Increased activity of acetylcholinesterase was also exhibited by d-gal injected rats while brain biogenic amines were significantly decreased. Food intake and growth rate were however comparable in both groups.
Together the behavioral, biochemical and neurochemical impairments following the high dose of d-gal suggest that symptoms similar to natural aging may be developed in rats in as early as one week.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2015.01.016</identifier><identifier>PMID: 25637686</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Acetylcholinesterase - metabolism ; Aging - physiology ; Animals ; Antioxidants - metabolism ; Behavior, Animal - physiology ; Behaviors ; Biogenic Amines - metabolism ; Brain - physiology ; Catalase - metabolism ; Chromatography, High Pressure Liquid ; d-Galactose ; Dose-Response Relationship, Drug ; Galactose - administration & dosage ; Galactose - pharmacology ; Glutathione Peroxidase - metabolism ; Lipid Peroxidation - physiology ; Male ; Maze Learning ; Memory - physiology ; Neurotransmitters ; Oxidative stress ; Rats ; Rats, Wistar ; Time Factors</subject><ispartof>Life sciences (1973), 2015-03, Vol.124, p.110-119</ispartof><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-3aef919b68713fa1bdf3e58f718866885de4f0d74d75a806821fb8e4ee18e5633</citedby><cites>FETCH-LOGICAL-c353t-3aef919b68713fa1bdf3e58f718866885de4f0d74d75a806821fb8e4ee18e5633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2015.01.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25637686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haider, Saida</creatorcontrib><creatorcontrib>Liaquat, Laraib</creatorcontrib><creatorcontrib>Shahzad, Sidrah</creatorcontrib><creatorcontrib>Sadir, Sadia</creatorcontrib><creatorcontrib>Madiha, Syeda</creatorcontrib><creatorcontrib>Batool, Zehra</creatorcontrib><creatorcontrib>Tabassum, Saiqa</creatorcontrib><creatorcontrib>Saleem, Sadia</creatorcontrib><creatorcontrib>Naqvi, Fizza</creatorcontrib><creatorcontrib>Perveen, Tahira</creatorcontrib><title>A high dose of short term exogenous d-galactose administration in young male rats produces symptoms simulating the natural aging process</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>d-Galactose (d-gal) induced accelerated senescence has been used to develop an aging model for brain. Previously, long term administration of a wide range of doses has been used for this purpose. In the present study we investigate whether short term administration of a high dose of d-gal in rats induces significant signs and symptoms similar to natural aging.
Young rats were injected intraperitoneally with d-gal at a dose of 300mg/ml/kg for one week. Behavioral analysis for depression and anxiety like symptoms were monitored by forced swim test (FST) and light/dark transition (LDT) test. Assessment of memory was done using the Morris water maze (MWM), passive avoidance test (PAT) and elevated plus maze (EPM) test. Biochemical analysis was done for estimation of antioxidant enzymes and acetylcholinesterase. Determination of brain biogenic amines was performed by HPLC–EC.
Short term administration of d-gal significantly altered behavioral, biochemical and neurochemical responses in rats. d-Gal injected rats exhibited depressogenic and anxiogenic behaviors while memory was also significantly impaired in these rats. Brain lipid peroxidation and superoxide dismutase activity were significantly increased while catalase and glutathione peroxidase decreased. Increased activity of acetylcholinesterase was also exhibited by d-gal injected rats while brain biogenic amines were significantly decreased. Food intake and growth rate were however comparable in both groups.
Together the behavioral, biochemical and neurochemical impairments following the high dose of d-gal suggest that symptoms similar to natural aging may be developed in rats in as early as one week.</description><subject>Acetylcholinesterase - metabolism</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Behavior, Animal - physiology</subject><subject>Behaviors</subject><subject>Biogenic Amines - metabolism</subject><subject>Brain - physiology</subject><subject>Catalase - metabolism</subject><subject>Chromatography, High Pressure Liquid</subject><subject>d-Galactose</subject><subject>Dose-Response Relationship, Drug</subject><subject>Galactose - administration & dosage</subject><subject>Galactose - pharmacology</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Lipid Peroxidation - physiology</subject><subject>Male</subject><subject>Maze Learning</subject><subject>Memory - physiology</subject><subject>Neurotransmitters</subject><subject>Oxidative stress</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Time Factors</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFqGzEQhkVpaZy0D9BL0TGXdTWrlVampxDaJhDopT0LeTVay6xWrqQN8Rv0sSvjJMfCwAzDN7_49RPyCdgaGMgv-_Xk8rplINYMask3ZAWq3zRMcnhLVoy1XcNbJi7IZc57xpgQPX9PLloheS-VXJG_N3Tnxx21MSONjuZdTIUWTIHiUxxxjkumthnNZIZyYowNfva5JFN8nKmf6TEu80iDmZDWZaaHFO0yYKb5GA4lhjr4sEyVr1jZIZ1NWZKZqBlPm4pXOH8g75yZMn587lfk9_dvv27vmoefP-5vbx6agQteGm7QbWCzlaoH7gxsreMolOtBKSmVEhY7x2zf2V4YxaRqwW0VdoigsLrmV-T6rFvf_bNgLjr4POA0mRmrVw1Sth0HpjYVhTM6pJhzQqcPyQeTjhqYPgWg97oGoE8BaAa1ZL35_Cy_bAPa14uXH6_A1zOA1eSjx6Tz4HEe0PqEQ9E2-v_I_wO8YJkr</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Haider, Saida</creator><creator>Liaquat, Laraib</creator><creator>Shahzad, Sidrah</creator><creator>Sadir, Sadia</creator><creator>Madiha, Syeda</creator><creator>Batool, Zehra</creator><creator>Tabassum, Saiqa</creator><creator>Saleem, Sadia</creator><creator>Naqvi, Fizza</creator><creator>Perveen, Tahira</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>A high dose of short term exogenous d-galactose administration in young male rats produces symptoms simulating the natural aging process</title><author>Haider, Saida ; Liaquat, Laraib ; Shahzad, Sidrah ; Sadir, Sadia ; Madiha, Syeda ; Batool, Zehra ; Tabassum, Saiqa ; Saleem, Sadia ; Naqvi, Fizza ; Perveen, Tahira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-3aef919b68713fa1bdf3e58f718866885de4f0d74d75a806821fb8e4ee18e5633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acetylcholinesterase - metabolism</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Behavior, Animal - physiology</topic><topic>Behaviors</topic><topic>Biogenic Amines - metabolism</topic><topic>Brain - physiology</topic><topic>Catalase - metabolism</topic><topic>Chromatography, High Pressure Liquid</topic><topic>d-Galactose</topic><topic>Dose-Response Relationship, Drug</topic><topic>Galactose - administration & dosage</topic><topic>Galactose - pharmacology</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Lipid Peroxidation - physiology</topic><topic>Male</topic><topic>Maze Learning</topic><topic>Memory - physiology</topic><topic>Neurotransmitters</topic><topic>Oxidative stress</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haider, Saida</creatorcontrib><creatorcontrib>Liaquat, Laraib</creatorcontrib><creatorcontrib>Shahzad, Sidrah</creatorcontrib><creatorcontrib>Sadir, Sadia</creatorcontrib><creatorcontrib>Madiha, Syeda</creatorcontrib><creatorcontrib>Batool, Zehra</creatorcontrib><creatorcontrib>Tabassum, Saiqa</creatorcontrib><creatorcontrib>Saleem, Sadia</creatorcontrib><creatorcontrib>Naqvi, Fizza</creatorcontrib><creatorcontrib>Perveen, Tahira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haider, Saida</au><au>Liaquat, Laraib</au><au>Shahzad, Sidrah</au><au>Sadir, Sadia</au><au>Madiha, Syeda</au><au>Batool, Zehra</au><au>Tabassum, Saiqa</au><au>Saleem, Sadia</au><au>Naqvi, Fizza</au><au>Perveen, Tahira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A high dose of short term exogenous d-galactose administration in young male rats produces symptoms simulating the natural aging process</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>124</volume><spage>110</spage><epage>119</epage><pages>110-119</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>d-Galactose (d-gal) induced accelerated senescence has been used to develop an aging model for brain. Previously, long term administration of a wide range of doses has been used for this purpose. In the present study we investigate whether short term administration of a high dose of d-gal in rats induces significant signs and symptoms similar to natural aging.
Young rats were injected intraperitoneally with d-gal at a dose of 300mg/ml/kg for one week. Behavioral analysis for depression and anxiety like symptoms were monitored by forced swim test (FST) and light/dark transition (LDT) test. Assessment of memory was done using the Morris water maze (MWM), passive avoidance test (PAT) and elevated plus maze (EPM) test. Biochemical analysis was done for estimation of antioxidant enzymes and acetylcholinesterase. Determination of brain biogenic amines was performed by HPLC–EC.
Short term administration of d-gal significantly altered behavioral, biochemical and neurochemical responses in rats. d-Gal injected rats exhibited depressogenic and anxiogenic behaviors while memory was also significantly impaired in these rats. Brain lipid peroxidation and superoxide dismutase activity were significantly increased while catalase and glutathione peroxidase decreased. Increased activity of acetylcholinesterase was also exhibited by d-gal injected rats while brain biogenic amines were significantly decreased. Food intake and growth rate were however comparable in both groups.
Together the behavioral, biochemical and neurochemical impairments following the high dose of d-gal suggest that symptoms similar to natural aging may be developed in rats in as early as one week.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>25637686</pmid><doi>10.1016/j.lfs.2015.01.016</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 2015-03, Vol.124, p.110-119 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acetylcholinesterase - metabolism Aging - physiology Animals Antioxidants - metabolism Behavior, Animal - physiology Behaviors Biogenic Amines - metabolism Brain - physiology Catalase - metabolism Chromatography, High Pressure Liquid d-Galactose Dose-Response Relationship, Drug Galactose - administration & dosage Galactose - pharmacology Glutathione Peroxidase - metabolism Lipid Peroxidation - physiology Male Maze Learning Memory - physiology Neurotransmitters Oxidative stress Rats Rats, Wistar Time Factors |
| title | A high dose of short term exogenous d-galactose administration in young male rats produces symptoms simulating the natural aging process |
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