Anti‐allergic Effect of Intranasal Administration of Type‐A Procyanidin Polyphenols Based Standardized Extract of Cinnamon Bark in Ovalbumin Sensitized BALB/c Mice
The objective of the present work was to evaluate anti‐allergic effects of intranasal administration of type‐A procynidines polyphenols (TAPP) based standardized hydroalcoholic extract of Cinnamomum zeylanicum bark (TAPP‐CZ) in ovalbumin (OVA)‐induced experimental allergic rhinitis (AR) in BALB/c mi...
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| Veröffentlicht in: | Phytotherapy research 2015-03, Vol.29 (3), p.423-433 |
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| creator | Aswar, Urmila M Kandhare, Amit D Mohan, Vishwaraman Thakurdesai, Prasad A |
| description | The objective of the present work was to evaluate anti‐allergic effects of intranasal administration of type‐A procynidines polyphenols (TAPP) based standardized hydroalcoholic extract of Cinnamomum zeylanicum bark (TAPP‐CZ) in ovalbumin (OVA)‐induced experimental allergic rhinitis (AR) in BALB/c mice. Sixty male BALB/c mice were divided into six groups of ten each (G1–G6). The mice from G1 were nonsensitized and maintained as normal group. Remaining mice (G2–G6) were sensitized with OVA (500 μL solution, intraperitoneal) on alternate days for 13 days and had twice daily intranasal treatment from day 14–21 as follows: G2 (AR control) received saline, G3 (positive control, XLY) received xylometazoline (0.5 mg/mL, 20 μL/nostril) and G4–G6 received TAPP‐CZ (3, 10 and 30 µg/kg in nostril), respectively. On day 21, mice were challenged with OVA (5 μL/nostril, 5% solution) and assessments (nasal signs, biochemical and histopathological) were performed. Treatment with TAPP‐CZ (10 and 30 µg/kg in nostril) showed significant attenuation in OVA‐induced alterations of the nasal (number of nasal rubbing and sneezing), biochemical markers (serum IgE and histamine), haematological, morphological (relative organ weight of spleen and lung) and histopathological (nasal mucosa and spleen) parameters. In conclusion, TAPP‐CZ showed anti‐allergic efficacy in animal model of AR. Copyright © 2014 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.5269 |
| format | Article |
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Sixty male BALB/c mice were divided into six groups of ten each (G1–G6). The mice from G1 were nonsensitized and maintained as normal group. Remaining mice (G2–G6) were sensitized with OVA (500 μL solution, intraperitoneal) on alternate days for 13 days and had twice daily intranasal treatment from day 14–21 as follows: G2 (AR control) received saline, G3 (positive control, XLY) received xylometazoline (0.5 mg/mL, 20 μL/nostril) and G4–G6 received TAPP‐CZ (3, 10 and 30 µg/kg in nostril), respectively. On day 21, mice were challenged with OVA (5 μL/nostril, 5% solution) and assessments (nasal signs, biochemical and histopathological) were performed. Treatment with TAPP‐CZ (10 and 30 µg/kg in nostril) showed significant attenuation in OVA‐induced alterations of the nasal (number of nasal rubbing and sneezing), biochemical markers (serum IgE and histamine), haematological, morphological (relative organ weight of spleen and lung) and histopathological (nasal mucosa and spleen) parameters. In conclusion, TAPP‐CZ showed anti‐allergic efficacy in animal model of AR. Copyright © 2014 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.5269</identifier><identifier>PMID: 25504814</identifier><identifier>CODEN: PHYREH</identifier><language>eng</language><publisher>England: Heyden & Son</publisher><subject>Administration, Intranasal ; allergic rhinitis ; animal models ; Animals ; Anti-Allergic Agents - pharmacology ; bark ; Biflavonoids - pharmacology ; biomarkers ; blood serum ; Catechin - pharmacology ; Cinnamomum verum ; Cinnamomum zeylanicum - chemistry ; Cinnamomum zeylanicum bark ; cinnamon ; Disease Models, Animal ; histamine ; Histamine - blood ; histopathology ; immunoglobulin E ; Immunoglobulin E - blood ; intranasal administration ; Male ; males ; Mice ; Mice, Inbred BALB C ; nasal mucosa ; Ovalbumin ; Plant Bark - chemistry ; Plant Extracts - pharmacology ; Polyphenols - pharmacology ; Proanthocyanidins - pharmacology ; procyanidins ; rhinitis ; Rhinitis, Allergic - drug therapy ; Sneezing ; spleen ; tissue weight ; type-A procyanidin polyphenols</subject><ispartof>Phytotherapy research, 2015-03, Vol.29 (3), p.423-433</ispartof><rights>Copyright © 2014 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2015 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4119-ec84e6331eb3f11b6edffbd69d63138aa33e0f63020a43ccded1e23b1923eb9a3</citedby><orcidid>0000-0002-9144-6600</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.5269$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.5269$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25504814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aswar, Urmila M</creatorcontrib><creatorcontrib>Kandhare, Amit D</creatorcontrib><creatorcontrib>Mohan, Vishwaraman</creatorcontrib><creatorcontrib>Thakurdesai, Prasad A</creatorcontrib><title>Anti‐allergic Effect of Intranasal Administration of Type‐A Procyanidin Polyphenols Based Standardized Extract of Cinnamon Bark in Ovalbumin Sensitized BALB/c Mice</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The objective of the present work was to evaluate anti‐allergic effects of intranasal administration of type‐A procynidines polyphenols (TAPP) based standardized hydroalcoholic extract of Cinnamomum zeylanicum bark (TAPP‐CZ) in ovalbumin (OVA)‐induced experimental allergic rhinitis (AR) in BALB/c mice. Sixty male BALB/c mice were divided into six groups of ten each (G1–G6). The mice from G1 were nonsensitized and maintained as normal group. Remaining mice (G2–G6) were sensitized with OVA (500 μL solution, intraperitoneal) on alternate days for 13 days and had twice daily intranasal treatment from day 14–21 as follows: G2 (AR control) received saline, G3 (positive control, XLY) received xylometazoline (0.5 mg/mL, 20 μL/nostril) and G4–G6 received TAPP‐CZ (3, 10 and 30 µg/kg in nostril), respectively. On day 21, mice were challenged with OVA (5 μL/nostril, 5% solution) and assessments (nasal signs, biochemical and histopathological) were performed. Treatment with TAPP‐CZ (10 and 30 µg/kg in nostril) showed significant attenuation in OVA‐induced alterations of the nasal (number of nasal rubbing and sneezing), biochemical markers (serum IgE and histamine), haematological, morphological (relative organ weight of spleen and lung) and histopathological (nasal mucosa and spleen) parameters. In conclusion, TAPP‐CZ showed anti‐allergic efficacy in animal model of AR. Copyright © 2014 John Wiley & Sons, Ltd.</description><subject>Administration, Intranasal</subject><subject>allergic rhinitis</subject><subject>animal models</subject><subject>Animals</subject><subject>Anti-Allergic Agents - pharmacology</subject><subject>bark</subject><subject>Biflavonoids - pharmacology</subject><subject>biomarkers</subject><subject>blood serum</subject><subject>Catechin - pharmacology</subject><subject>Cinnamomum verum</subject><subject>Cinnamomum zeylanicum - chemistry</subject><subject>Cinnamomum zeylanicum bark</subject><subject>cinnamon</subject><subject>Disease Models, Animal</subject><subject>histamine</subject><subject>Histamine - blood</subject><subject>histopathology</subject><subject>immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>intranasal administration</subject><subject>Male</subject><subject>males</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>nasal mucosa</subject><subject>Ovalbumin</subject><subject>Plant Bark - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Polyphenols - pharmacology</subject><subject>Proanthocyanidins - pharmacology</subject><subject>procyanidins</subject><subject>rhinitis</subject><subject>Rhinitis, Allergic - drug therapy</subject><subject>Sneezing</subject><subject>spleen</subject><subject>tissue weight</subject><subject>type-A procyanidin polyphenols</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd1u1DAQhS0EoktB4gnAEjfcpPVP_nyZXZZSaaELu1V7ZznxpLgkzmIn0HDFI_AWvBdPgsOWInE1Gs13zozmIPSUkiNKCDve9e4oYam4h2aUCBHRJOP30YyIhEYxzS8P0CPvrwkhgpH4ITpgSULinMYz9LOwvfn1_YdqGnBXpsLLuoaqx12NT23vlFVeNbjQrbHGh743nZ2G23EHQVbgteuqUVmjjcXrrhl3H8F2jcdz5UHjTa-sVk6bb6FZ3gSDvffCWKvaYDVX7hMO0rMvqimHsAVvwHrT_xHMi9X8uMJvTQWP0YNaNR6e3NZDdP56uV28iVZnJ6eLYhVVMaUigiqPIeWcQslrSssUdF2XOhU65ZTnSnEOpE45YUTFvKo0aAqMl1QwDqVQ_BC93PvuXPd5AN_L1vgKmkZZ6AYvaZqymJMkZwF98R963Q3OhusmirI8fFkE6tktNZQtaLlzplVulH8jCEC0B76aBsa7OSVyilaGaOUUrVxvP0z1Hx_ygJs7PvxRphnPEnnx7kS-yi7fk2y9kheBf77na9VJdeWMl-cbRmhCCM2zTGT8N-qLsd4</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Aswar, Urmila M</creator><creator>Kandhare, Amit D</creator><creator>Mohan, Vishwaraman</creator><creator>Thakurdesai, Prasad A</creator><general>Heyden & Son</general><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9144-6600</orcidid></search><sort><creationdate>201503</creationdate><title>Anti‐allergic Effect of Intranasal Administration of Type‐A Procyanidin Polyphenols Based Standardized Extract of Cinnamon Bark in Ovalbumin Sensitized BALB/c Mice</title><author>Aswar, Urmila M ; Kandhare, Amit D ; Mohan, Vishwaraman ; Thakurdesai, Prasad A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4119-ec84e6331eb3f11b6edffbd69d63138aa33e0f63020a43ccded1e23b1923eb9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Administration, Intranasal</topic><topic>allergic rhinitis</topic><topic>animal models</topic><topic>Animals</topic><topic>Anti-Allergic Agents - pharmacology</topic><topic>bark</topic><topic>Biflavonoids - pharmacology</topic><topic>biomarkers</topic><topic>blood serum</topic><topic>Catechin - pharmacology</topic><topic>Cinnamomum verum</topic><topic>Cinnamomum zeylanicum - chemistry</topic><topic>Cinnamomum zeylanicum bark</topic><topic>cinnamon</topic><topic>Disease Models, Animal</topic><topic>histamine</topic><topic>Histamine - blood</topic><topic>histopathology</topic><topic>immunoglobulin E</topic><topic>Immunoglobulin E - blood</topic><topic>intranasal administration</topic><topic>Male</topic><topic>males</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>nasal mucosa</topic><topic>Ovalbumin</topic><topic>Plant Bark - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Polyphenols - pharmacology</topic><topic>Proanthocyanidins - pharmacology</topic><topic>procyanidins</topic><topic>rhinitis</topic><topic>Rhinitis, Allergic - drug therapy</topic><topic>Sneezing</topic><topic>spleen</topic><topic>tissue weight</topic><topic>type-A procyanidin polyphenols</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aswar, Urmila M</creatorcontrib><creatorcontrib>Kandhare, Amit D</creatorcontrib><creatorcontrib>Mohan, Vishwaraman</creatorcontrib><creatorcontrib>Thakurdesai, Prasad A</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aswar, Urmila M</au><au>Kandhare, Amit D</au><au>Mohan, Vishwaraman</au><au>Thakurdesai, Prasad A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti‐allergic Effect of Intranasal Administration of Type‐A Procyanidin Polyphenols Based Standardized Extract of Cinnamon Bark in Ovalbumin Sensitized BALB/c Mice</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2015-03</date><risdate>2015</risdate><volume>29</volume><issue>3</issue><spage>423</spage><epage>433</epage><pages>423-433</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><coden>PHYREH</coden><abstract>The objective of the present work was to evaluate anti‐allergic effects of intranasal administration of type‐A procynidines polyphenols (TAPP) based standardized hydroalcoholic extract of Cinnamomum zeylanicum bark (TAPP‐CZ) in ovalbumin (OVA)‐induced experimental allergic rhinitis (AR) in BALB/c mice. Sixty male BALB/c mice were divided into six groups of ten each (G1–G6). The mice from G1 were nonsensitized and maintained as normal group. Remaining mice (G2–G6) were sensitized with OVA (500 μL solution, intraperitoneal) on alternate days for 13 days and had twice daily intranasal treatment from day 14–21 as follows: G2 (AR control) received saline, G3 (positive control, XLY) received xylometazoline (0.5 mg/mL, 20 μL/nostril) and G4–G6 received TAPP‐CZ (3, 10 and 30 µg/kg in nostril), respectively. On day 21, mice were challenged with OVA (5 μL/nostril, 5% solution) and assessments (nasal signs, biochemical and histopathological) were performed. Treatment with TAPP‐CZ (10 and 30 µg/kg in nostril) showed significant attenuation in OVA‐induced alterations of the nasal (number of nasal rubbing and sneezing), biochemical markers (serum IgE and histamine), haematological, morphological (relative organ weight of spleen and lung) and histopathological (nasal mucosa and spleen) parameters. In conclusion, TAPP‐CZ showed anti‐allergic efficacy in animal model of AR. Copyright © 2014 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Heyden & Son</pub><pmid>25504814</pmid><doi>10.1002/ptr.5269</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9144-6600</orcidid></addata></record> |
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| subjects | Administration, Intranasal allergic rhinitis animal models Animals Anti-Allergic Agents - pharmacology bark Biflavonoids - pharmacology biomarkers blood serum Catechin - pharmacology Cinnamomum verum Cinnamomum zeylanicum - chemistry Cinnamomum zeylanicum bark cinnamon Disease Models, Animal histamine Histamine - blood histopathology immunoglobulin E Immunoglobulin E - blood intranasal administration Male males Mice Mice, Inbred BALB C nasal mucosa Ovalbumin Plant Bark - chemistry Plant Extracts - pharmacology Polyphenols - pharmacology Proanthocyanidins - pharmacology procyanidins rhinitis Rhinitis, Allergic - drug therapy Sneezing spleen tissue weight type-A procyanidin polyphenols |
| title | Anti‐allergic Effect of Intranasal Administration of Type‐A Procyanidin Polyphenols Based Standardized Extract of Cinnamon Bark in Ovalbumin Sensitized BALB/c Mice |
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