Metabolic parameters in rats receiving different levels of oral glycerol supplementation
The use of glycerol in the diets for animals is of interest because it is a residue of biodiesel production and rich in energy. Thus, this study aimed to evaluate metabolic and physiological parameters of rats receiving supplemental pure glycerol by gavage. We used 30 Wistar rats (initial weight 202...
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| Veröffentlicht in: | Journal of animal physiology and animal nutrition 2015-04, Vol.99 (2), p.265-272 |
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| creator | Lisenko, K. G Andrade, E. F Lobato, R. V Orlando, D. R Damin, D. H. C Costa, A. C Lima, R. R Alvarenga, R. R Zangeronimo, M. G Sousa, R. V Pereira, L. J |
| description | The use of glycerol in the diets for animals is of interest because it is a residue of biodiesel production and rich in energy. Thus, this study aimed to evaluate metabolic and physiological parameters of rats receiving supplemental pure glycerol by gavage. We used 30 Wistar rats (initial weight 202.7 ± 29.98 g) receiving 0 (control/saline), 200, 400, 800 and 1600 mg glycerol/kg of body weight (bidistilled glycerine, 99.85% glycerol) beside food and water ad libitum for 28 days. We used a completely randomised design with five treatments and six replicates. At the end of the experiment, the animals were killed, and the results showed that there was no change (p > 0.05) in the intake and excretion of water, the average daily weight gain, dry matter, ash and crude protein in the carcass or plasma triacylglycerols. There was a beneficial effect (p |
| doi_str_mv | 10.1111/jpn.12217 |
| format | Article |
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G ; Andrade, E. F ; Lobato, R. V ; Orlando, D. R ; Damin, D. H. C ; Costa, A. C ; Lima, R. R ; Alvarenga, R. R ; Zangeronimo, M. G ; Sousa, R. V ; Pereira, L. J</creator><creatorcontrib>Lisenko, K. G ; Andrade, E. F ; Lobato, R. V ; Orlando, D. R ; Damin, D. H. C ; Costa, A. C ; Lima, R. R ; Alvarenga, R. R ; Zangeronimo, M. G ; Sousa, R. V ; Pereira, L. J</creatorcontrib><description>The use of glycerol in the diets for animals is of interest because it is a residue of biodiesel production and rich in energy. Thus, this study aimed to evaluate metabolic and physiological parameters of rats receiving supplemental pure glycerol by gavage. We used 30 Wistar rats (initial weight 202.7 ± 29.98 g) receiving 0 (control/saline), 200, 400, 800 and 1600 mg glycerol/kg of body weight (bidistilled glycerine, 99.85% glycerol) beside food and water ad libitum for 28 days. We used a completely randomised design with five treatments and six replicates. At the end of the experiment, the animals were killed, and the results showed that there was no change (p > 0.05) in the intake and excretion of water, the average daily weight gain, dry matter, ash and crude protein in the carcass or plasma triacylglycerols. There was a beneficial effect (p < 0.05) up to a dose of 800 mg/kg glycerol on feed intake, percentage of carcass fat, plasma levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), high‐density lipoprotein (HDLc) and low‐/very low‐density lipoprotein (LDLc + VLDLc). The levels of total cholesterol and glucose were increased with up to a dose of 800 mg/kg glycerol (but remained within the normal range); they were reduced with the dose of 1600 mg/kg. The total leucocyte count tended to be reduced, although it was within the reference values for rats. There were no renal or pancreatic lesions. In conclusion, glycerol presented as a safe supplement at the studied doses, even having some beneficial effects in a dose‐dependent manner in rats.</description><identifier>ISSN: 0931-2439</identifier><identifier>EISSN: 1439-0396</identifier><identifier>DOI: 10.1111/jpn.12217</identifier><identifier>PMID: 24996054</identifier><language>eng</language><publisher>Germany: Blackwell Science</publisher><subject>Administration, Oral ; alanine transaminase ; Animal Feed - analysis ; animal nutrition ; Animals ; aspartate transaminase ; biodiesel ; body weight ; cholesterol ; crude protein ; Diet ; Dietary Supplements ; dose response ; Dose-Response Relationship, Drug ; energy ; excretion ; feed intake ; fuel production ; glucose ; glycerine ; glycerol ; Glycerol - administration & dosage ; Glycerol - metabolism ; Glycerol - pharmacokinetics ; high density lipoprotein ; leukocyte count ; low density lipoprotein ; Male ; metabolism ; normal values ; Random Allocation ; Rats ; supplementary feeding ; triacylglycerols ; weight gain</subject><ispartof>Journal of animal physiology and animal nutrition, 2015-04, Vol.99 (2), p.265-272</ispartof><rights>Journal of Animal Physiology and Animal Nutrition © 2014 Blackwell Verlag GmbH</rights><rights>Journal of Animal Physiology and Animal Nutrition © 2014 Blackwell Verlag GmbH.</rights><rights>2015 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4157-29f6a84d1edd3f4af57c708e041d23b691b747849d942fb4a811b2d71b890f4f3</citedby><cites>FETCH-LOGICAL-c4157-29f6a84d1edd3f4af57c708e041d23b691b747849d942fb4a811b2d71b890f4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjpn.12217$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjpn.12217$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24996054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lisenko, K. G</creatorcontrib><creatorcontrib>Andrade, E. F</creatorcontrib><creatorcontrib>Lobato, R. V</creatorcontrib><creatorcontrib>Orlando, D. R</creatorcontrib><creatorcontrib>Damin, D. H. C</creatorcontrib><creatorcontrib>Costa, A. C</creatorcontrib><creatorcontrib>Lima, R. R</creatorcontrib><creatorcontrib>Alvarenga, R. R</creatorcontrib><creatorcontrib>Zangeronimo, M. G</creatorcontrib><creatorcontrib>Sousa, R. V</creatorcontrib><creatorcontrib>Pereira, L. J</creatorcontrib><title>Metabolic parameters in rats receiving different levels of oral glycerol supplementation</title><title>Journal of animal physiology and animal nutrition</title><addtitle>J Anim Physiol Anim Nutr</addtitle><description>The use of glycerol in the diets for animals is of interest because it is a residue of biodiesel production and rich in energy. Thus, this study aimed to evaluate metabolic and physiological parameters of rats receiving supplemental pure glycerol by gavage. We used 30 Wistar rats (initial weight 202.7 ± 29.98 g) receiving 0 (control/saline), 200, 400, 800 and 1600 mg glycerol/kg of body weight (bidistilled glycerine, 99.85% glycerol) beside food and water ad libitum for 28 days. We used a completely randomised design with five treatments and six replicates. At the end of the experiment, the animals were killed, and the results showed that there was no change (p > 0.05) in the intake and excretion of water, the average daily weight gain, dry matter, ash and crude protein in the carcass or plasma triacylglycerols. There was a beneficial effect (p < 0.05) up to a dose of 800 mg/kg glycerol on feed intake, percentage of carcass fat, plasma levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), high‐density lipoprotein (HDLc) and low‐/very low‐density lipoprotein (LDLc + VLDLc). The levels of total cholesterol and glucose were increased with up to a dose of 800 mg/kg glycerol (but remained within the normal range); they were reduced with the dose of 1600 mg/kg. The total leucocyte count tended to be reduced, although it was within the reference values for rats. There were no renal or pancreatic lesions. In conclusion, glycerol presented as a safe supplement at the studied doses, even having some beneficial effects in a dose‐dependent manner in rats.</description><subject>Administration, Oral</subject><subject>alanine transaminase</subject><subject>Animal Feed - analysis</subject><subject>animal nutrition</subject><subject>Animals</subject><subject>aspartate transaminase</subject><subject>biodiesel</subject><subject>body weight</subject><subject>cholesterol</subject><subject>crude protein</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>dose response</subject><subject>Dose-Response Relationship, Drug</subject><subject>energy</subject><subject>excretion</subject><subject>feed intake</subject><subject>fuel production</subject><subject>glucose</subject><subject>glycerine</subject><subject>glycerol</subject><subject>Glycerol - administration & dosage</subject><subject>Glycerol - metabolism</subject><subject>Glycerol - pharmacokinetics</subject><subject>high density lipoprotein</subject><subject>leukocyte count</subject><subject>low density lipoprotein</subject><subject>Male</subject><subject>metabolism</subject><subject>normal values</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>supplementary feeding</subject><subject>triacylglycerols</subject><subject>weight gain</subject><issn>0931-2439</issn><issn>1439-0396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10c1u1DAUBWALgehQWPACYIkNLNL6L3a8RAUKVSmVSgU7y0muRx48cbCTwrw9HtJ2gYQ3lqzvHlnnIvSckiNazvFmHI4oY1Q9QCsquK4I1_IhWhHNacXKwwF6kvOGEKpqIh-jAya0lqQWK_T9M0y2jcF3eLTJbmGClLEfcLJTxgk68Dd-WOPeOwcJhgkHuIGQcXQ4JhvwOuw6SDHgPI9jgG0hdvJxeIoeORsyPLu9D9H1h_dfTz5W519OP528Pa86QWtVMe2kbURPoe-5E9bVqlOkASJoz3grNW2VUI3QvRbMtcI2lLasV7RtNHHC8UP0eskdU_w5Q57M1ucOQrADxDkbKiUTrKkZL_TVP3QT5zSU3-0V0bQmYq_eLKpLMecEzozJb23aGUrMvm5T6jZ_6y72xW3i3G6hv5d3_RZwvIBfPsDu_0nm7PLiLrJaJnye4Pf9hE0_jFRc1ebbxam5ujzjqnmnjC7-5eKdjcauk8_m-ooRKsu2SS014X8Ay5yhVA</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Lisenko, K. G</creator><creator>Andrade, E. F</creator><creator>Lobato, R. V</creator><creator>Orlando, D. R</creator><creator>Damin, D. H. C</creator><creator>Costa, A. C</creator><creator>Lima, R. R</creator><creator>Alvarenga, R. R</creator><creator>Zangeronimo, M. G</creator><creator>Sousa, R. V</creator><creator>Pereira, L. J</creator><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201504</creationdate><title>Metabolic parameters in rats receiving different levels of oral glycerol supplementation</title><author>Lisenko, K. G ; Andrade, E. F ; Lobato, R. V ; Orlando, D. R ; Damin, D. H. C ; Costa, A. C ; Lima, R. R ; Alvarenga, R. R ; Zangeronimo, M. G ; Sousa, R. V ; Pereira, L. 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G</creatorcontrib><creatorcontrib>Andrade, E. F</creatorcontrib><creatorcontrib>Lobato, R. V</creatorcontrib><creatorcontrib>Orlando, D. R</creatorcontrib><creatorcontrib>Damin, D. H. C</creatorcontrib><creatorcontrib>Costa, A. C</creatorcontrib><creatorcontrib>Lima, R. R</creatorcontrib><creatorcontrib>Alvarenga, R. R</creatorcontrib><creatorcontrib>Zangeronimo, M. G</creatorcontrib><creatorcontrib>Sousa, R. V</creatorcontrib><creatorcontrib>Pereira, L. J</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal physiology and animal nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lisenko, K. G</au><au>Andrade, E. F</au><au>Lobato, R. V</au><au>Orlando, D. R</au><au>Damin, D. H. C</au><au>Costa, A. C</au><au>Lima, R. R</au><au>Alvarenga, R. R</au><au>Zangeronimo, M. G</au><au>Sousa, R. V</au><au>Pereira, L. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic parameters in rats receiving different levels of oral glycerol supplementation</atitle><jtitle>Journal of animal physiology and animal nutrition</jtitle><addtitle>J Anim Physiol Anim Nutr</addtitle><date>2015-04</date><risdate>2015</risdate><volume>99</volume><issue>2</issue><spage>265</spage><epage>272</epage><pages>265-272</pages><issn>0931-2439</issn><eissn>1439-0396</eissn><abstract>The use of glycerol in the diets for animals is of interest because it is a residue of biodiesel production and rich in energy. Thus, this study aimed to evaluate metabolic and physiological parameters of rats receiving supplemental pure glycerol by gavage. We used 30 Wistar rats (initial weight 202.7 ± 29.98 g) receiving 0 (control/saline), 200, 400, 800 and 1600 mg glycerol/kg of body weight (bidistilled glycerine, 99.85% glycerol) beside food and water ad libitum for 28 days. We used a completely randomised design with five treatments and six replicates. At the end of the experiment, the animals were killed, and the results showed that there was no change (p > 0.05) in the intake and excretion of water, the average daily weight gain, dry matter, ash and crude protein in the carcass or plasma triacylglycerols. There was a beneficial effect (p < 0.05) up to a dose of 800 mg/kg glycerol on feed intake, percentage of carcass fat, plasma levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), high‐density lipoprotein (HDLc) and low‐/very low‐density lipoprotein (LDLc + VLDLc). The levels of total cholesterol and glucose were increased with up to a dose of 800 mg/kg glycerol (but remained within the normal range); they were reduced with the dose of 1600 mg/kg. The total leucocyte count tended to be reduced, although it was within the reference values for rats. There were no renal or pancreatic lesions. In conclusion, glycerol presented as a safe supplement at the studied doses, even having some beneficial effects in a dose‐dependent manner in rats.</abstract><cop>Germany</cop><pub>Blackwell Science</pub><pmid>24996054</pmid><doi>10.1111/jpn.12217</doi><tpages>8</tpages></addata></record> |
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| subjects | Administration, Oral alanine transaminase Animal Feed - analysis animal nutrition Animals aspartate transaminase biodiesel body weight cholesterol crude protein Diet Dietary Supplements dose response Dose-Response Relationship, Drug energy excretion feed intake fuel production glucose glycerine glycerol Glycerol - administration & dosage Glycerol - metabolism Glycerol - pharmacokinetics high density lipoprotein leukocyte count low density lipoprotein Male metabolism normal values Random Allocation Rats supplementary feeding triacylglycerols weight gain |
| title | Metabolic parameters in rats receiving different levels of oral glycerol supplementation |
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