Improvement of the stability and activity of the BPO-A1 haloperoxidase from Streptomyces aureofaciens by directed evolution

•Directed evolution was adopted to improve thermostability of the haloperoxidase.•Two mutant haloperoxidases having higher thermostabilities were obtained.•One mutant acquired higher thermo- and organic solvent stabilities simultaneously.•The residues responsible for thermo- and organic solvent stab...

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