Induction and Repair of DNA Double-Strand Breaks

Induction and repair of DNA double-strand breaks (DSBs) was measured using a pulsed-field gel electrophoresis system. A cell line of methotrexate-resistant EMT-6 cells that contain numerous double-minutes (DMs) 3 million base pairs in size was employed. The electrophoretic mobility of these DMs depe...

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Veröffentlicht in:	Radiation research 1993-03, Vol.133 (3), p.370-374
Hauptverfasser:	Nevaldine, Barbara, Longo, John A., King, Gerald A., Vilenchik, Michael, Sagerman, Robert H., Hahn, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biological effects of radiation Cell culture techniques Cell Line Cell lines CHO cells Cultured cells DNA DNA - radiation effects DNA Damage - radiation effects DNA probes DNA Repair Dose-Response Relationship, Radiation Electrophoresis Electrophoresis, Gel, Pulsed-Field Fundamental and applied biological sciences. Psychology Gels Ionizing radiations Kinetics Radiation dosage Tissues, organs and organisms biophysics
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