Brain Targeting of anti-HIV Nucleosides: Ether Prodrugs of 3′-Azido-2′,3′-Dideoxyuridine (AZdU) and 3′-Azido-3′-Deoxythymidine (AZT)

In an effort to increase the brain delivery of anti-HIV nucleosides, 5-0-benzyl and glucose derivatives of 3′-azido-2′,3′-dideoxyuridine (AZdU or CS-87) and 3′-azido-3′-deoxythymidine (AZT) were synthesized. In vitro stability and pharmacokinetic studies in mice were conducted with benzyl AZdU (BzlA...

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Veröffentlicht in:	Antiviral chemistry & chemotherapy 1993-10, Vol.4 (5), p.263-269
Hauptverfasser:	Doshi, K. J., Islam, Q., Gallo, J. M., Boudinot, F. D., Hsieh, L., Qin, Y., Schinazi, R. F., Chu, C. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences High-performance liquid chromatography HIV Human immunodeficiency virus Intravenous administration Medical sciences Metabolites Nucleosides Pharmacokinetics Pharmacology. Drug treatments Prodrugs Zidovudine
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