Pharmacology of organophosphates
The cholinergic nerve fibers, which employ acetylcholine (ACh) as a neurohumoral transmitter, and the results of their activation are listed. The reactions between the enzyme acetylcholinesterase (AChE), its natural substrate, ACh, and the various types of inhibitors are described. The limited thera...
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| Veröffentlicht in: | Journal of applied toxicology 1994-03, Vol.14 (2), p.105-109 |
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| container_end_page | 109 |
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| container_title | Journal of applied toxicology |
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| creator | Koelle, George B. |
| description | The cholinergic nerve fibers, which employ acetylcholine (ACh) as a neurohumoral transmitter, and the results of their activation are listed. The reactions between the enzyme acetylcholinesterase (AChE), its natural substrate, ACh, and the various types of inhibitors are described. The limited therapeutic uses of the anticholinesterase (anti‐ChE) agents are considered. The toxicological effects encountered when the anti‐ChE agents are employed as insecticides or as chemical warfare (CW) agents are discussed. Certain anti‐ChE agents produce also a delayed neurotoxic effect which is apparently unrelated to the inhibition of AChE. |
| doi_str_mv | 10.1002/jat.2550140211 |
| format | Article |
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The reactions between the enzyme acetylcholinesterase (AChE), its natural substrate, ACh, and the various types of inhibitors are described. The limited therapeutic uses of the anticholinesterase (anti‐ChE) agents are considered. The toxicological effects encountered when the anti‐ChE agents are employed as insecticides or as chemical warfare (CW) agents are discussed. Certain anti‐ChE agents produce also a delayed neurotoxic effect which is apparently unrelated to the inhibition of AChE.</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.2550140211</identifier><identifier>PMID: 8027504</identifier><identifier>CODEN: JJATDK</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>acetylcholinesterase inhibitors ; anticholinesterase agents ; Biological and medical sciences ; Chemical and industrial products toxicology. 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Appl. Toxicol</addtitle><description>The cholinergic nerve fibers, which employ acetylcholine (ACh) as a neurohumoral transmitter, and the results of their activation are listed. The reactions between the enzyme acetylcholinesterase (AChE), its natural substrate, ACh, and the various types of inhibitors are described. The limited therapeutic uses of the anticholinesterase (anti‐ChE) agents are considered. The toxicological effects encountered when the anti‐ChE agents are employed as insecticides or as chemical warfare (CW) agents are discussed. Certain anti‐ChE agents produce also a delayed neurotoxic effect which is apparently unrelated to the inhibition of AChE.</description><subject>acetylcholinesterase inhibitors</subject><subject>anticholinesterase agents</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>chemical warfare agents</subject><subject>Chemical Warfare Agents - toxicity</subject><subject>Cholinesterase Inhibitors - metabolism</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>dipole-induced dipole bond</subject><subject>epidemiology</subject><subject>Eye - drug effects</subject><subject>Humans</subject><subject>Hydrolysis</subject><subject>Insecticides - toxicity</subject><subject>Medical sciences</subject><subject>ocular effects</subject><subject>organophosphates</subject><subject>Organophosphorus Compounds - chemistry</subject><subject>Organophosphorus Compounds - metabolism</subject><subject>Organophosphorus Compounds - pharmacology</subject><subject>Receptors, Cholinergic - classification</subject><subject>Receptors, Cholinergic - drug effects</subject><subject>Receptors, Cholinergic - metabolism</subject><subject>Structure-Activity Relationship</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1PAjEQxRujQUSv3kw4GG-L089lj4QIigSN2ai3ppQuLC50bSHKf2_JbjCevEwneb_3pnkIXWLoYAByu1SbDuEcMAOC8RFqYkiSCBNBj1ETiICI0fj9FJ15vwQIGuk2UKMLJObAmqj9vFBupbQt7HzXtlnburla23JhfblQG-PP0UmmCm8u6reF0sFd2r-Pxk_Dh35vHOmQgyMSqxlQ3tXThFNKVEIAa8aFBpYYoWmXM0whpmEPg7EsYRwzHDihqMloC91UsaWzn1vjN3KVe22KQq2N3XqJhSBAQnYLdSpQO-u9M5ksXb5SbicxyH0jMjQifxsJhqs6eTtdmdkBrysI-nWtK69VkTm11rk_YAyHLskeSyrsKy_M7p-jctRL_3whqry535jvg1e5DyliGnP5NhnKwQsbpeL1UU7oD077hbA</recordid><startdate>199403</startdate><enddate>199403</enddate><creator>Koelle, George B.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>199403</creationdate><title>Pharmacology of organophosphates</title><author>Koelle, George B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5041-27ad0358cb95332a9201c456c049e6c385413073e6c73e44f945141a926a3ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>acetylcholinesterase inhibitors</topic><topic>anticholinesterase agents</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>chemical warfare agents</topic><topic>Chemical Warfare Agents - toxicity</topic><topic>Cholinesterase Inhibitors - metabolism</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>dipole-induced dipole bond</topic><topic>epidemiology</topic><topic>Eye - drug effects</topic><topic>Humans</topic><topic>Hydrolysis</topic><topic>Insecticides - toxicity</topic><topic>Medical sciences</topic><topic>ocular effects</topic><topic>organophosphates</topic><topic>Organophosphorus Compounds - chemistry</topic><topic>Organophosphorus Compounds - metabolism</topic><topic>Organophosphorus Compounds - pharmacology</topic><topic>Receptors, Cholinergic - classification</topic><topic>Receptors, Cholinergic - drug effects</topic><topic>Receptors, Cholinergic - metabolism</topic><topic>Structure-Activity Relationship</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koelle, George B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koelle, George B.</au><au>Katz, A (eds)</au><au>Seabaugh, V</au><au>Koelle, GB</au><au>Salem, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacology of organophosphates</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>1994-03</date><risdate>1994</risdate><volume>14</volume><issue>2</issue><spage>105</spage><epage>109</epage><pages>105-109</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>The cholinergic nerve fibers, which employ acetylcholine (ACh) as a neurohumoral transmitter, and the results of their activation are listed. The reactions between the enzyme acetylcholinesterase (AChE), its natural substrate, ACh, and the various types of inhibitors are described. The limited therapeutic uses of the anticholinesterase (anti‐ChE) agents are considered. The toxicological effects encountered when the anti‐ChE agents are employed as insecticides or as chemical warfare (CW) agents are discussed. Certain anti‐ChE agents produce also a delayed neurotoxic effect which is apparently unrelated to the inhibition of AChE.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><pmid>8027504</pmid><doi>10.1002/jat.2550140211</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of applied toxicology, 1994-03, Vol.14 (2), p.105-109 |
| issn | 0260-437X 1099-1263 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | acetylcholinesterase inhibitors anticholinesterase agents Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases chemical warfare agents Chemical Warfare Agents - toxicity Cholinesterase Inhibitors - metabolism Cholinesterase Inhibitors - pharmacology dipole-induced dipole bond epidemiology Eye - drug effects Humans Hydrolysis Insecticides - toxicity Medical sciences ocular effects organophosphates Organophosphorus Compounds - chemistry Organophosphorus Compounds - metabolism Organophosphorus Compounds - pharmacology Receptors, Cholinergic - classification Receptors, Cholinergic - drug effects Receptors, Cholinergic - metabolism Structure-Activity Relationship Toxicology Various organic compounds |
| title | Pharmacology of organophosphates |
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