Piperine prevents cholesterol gallstones formation in mice
Biliary cholesterol may contribute to the formation of cholesterol gallstones, and regulation of these levels could be a useful therapeutic strategy for gallstones disease. Piperine (PA) is a potential cholesterol lowering agent. In this study, we assessed the effect and mechanism of PA in preventin...
Gespeichert in:
| Veröffentlicht in: | European journal of pharmacology 2015-03, Vol.751, p.112-117 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 117 |
|---|---|
| container_issue | |
| container_start_page | 112 |
| container_title | European journal of pharmacology |
| container_volume | 751 |
| creator | Song, Xiu-Yun Xu, Shuang Hu, Jin-Feng Tang, Jia Chu, Shi-Feng Liu, Hang Han, Ning Li, Jing-Wei Zhang, Dong-Ming Li, Yue-Ting Chen, Nai-Hong |
| description | Biliary cholesterol may contribute to the formation of cholesterol gallstones, and regulation of these levels could be a useful therapeutic strategy for gallstones disease. Piperine (PA) is a potential cholesterol lowering agent. In this study, we assessed the effect and mechanism of PA in preventing cholesterol gallstones formation induced by feeding lithogenic diet containing high cholesterol levels to mice. C57BL/6 inbred mice were fed lithogenic or chow diets for 10 weeks, with or without PA (15, 30 and 60mg/kg) or ursodeoxycholic acid (UDCA, 60mg/kg) administration. Cholesterol, phospholipids and crystals in bile, the lipid in serum, pathological changes and proteins expression in liver were analyzed. The results showed that PA could decrease the cholesterol potency and crystals in bile, reduce total cholesterol (TC), triglycerides (TG) and increase high-density lipoprotein/low-density lipoprotein (HDL/LDL) levels in serum. Furthermore, PA treatment reduced liver lipid peroxidation and protected hepatobiliary cells from liver injury by decreasing malondialdehyde (MDA) and increasing superoxide dismutase (SOD). In addition, PA inhibited the expression of ATP-binding cassette transporters G5/8 (ABCG5/8) and liver X receptor (LXR) in liver, and reduced cholesterol transport from the hepatocytes to the gallbladder. It may be the mechanism of PA in preventing cholesterol gallstones formation. PA as a potential drug for prevention cholesterol gallstones merits further investigation. |
| doi_str_mv | 10.1016/j.ejphar.2015.01.038 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1662003426</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014299915000710</els_id><sourcerecordid>1662003426</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-6158521cf797b7ac0f4a5f71c0939e61c68926fb13de2fabd3ffe0346367d6733</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMoun78A5EevbTOJG3aeBBE_AJBD3oO2XSiWdqmJl3Bf29l1aOnuTzvvDMPY8cIBQLKs1VBq_HNxIIDVgVgAaLZYgtsapVDjXybLQCwzLlSao_tp7QCgErxapft8UqWVYN8wc6f_EjRD5SNkT5omFJm30JHaaIYuuzVdF2awkApcyH2ZvJhyPyQ9d7SIdtxpkt09DMP2MvN9fPVXf7weHt_dfmQWyH5lEusmoqjdbWql7Wx4EpTuRotKKFIopWN4tItUbTEnVm2wjkCUUoh61bWQhyw083eMYb39XyZ7n2y1HVmoLBOGqXkMAe4nNFyg9oYUork9Bh9b-KnRtDf1vRKb6zpb2saUM_W5tjJT8N62VP7F_rVNAMXG4DmPz88RZ2sp8FS6yPZSbfB_9_wBdYef4Y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1662003426</pqid></control><display><type>article</type><title>Piperine prevents cholesterol gallstones formation in mice</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Song, Xiu-Yun ; Xu, Shuang ; Hu, Jin-Feng ; Tang, Jia ; Chu, Shi-Feng ; Liu, Hang ; Han, Ning ; Li, Jing-Wei ; Zhang, Dong-Ming ; Li, Yue-Ting ; Chen, Nai-Hong</creator><creatorcontrib>Song, Xiu-Yun ; Xu, Shuang ; Hu, Jin-Feng ; Tang, Jia ; Chu, Shi-Feng ; Liu, Hang ; Han, Ning ; Li, Jing-Wei ; Zhang, Dong-Ming ; Li, Yue-Ting ; Chen, Nai-Hong</creatorcontrib><description>Biliary cholesterol may contribute to the formation of cholesterol gallstones, and regulation of these levels could be a useful therapeutic strategy for gallstones disease. Piperine (PA) is a potential cholesterol lowering agent. In this study, we assessed the effect and mechanism of PA in preventing cholesterol gallstones formation induced by feeding lithogenic diet containing high cholesterol levels to mice. C57BL/6 inbred mice were fed lithogenic or chow diets for 10 weeks, with or without PA (15, 30 and 60mg/kg) or ursodeoxycholic acid (UDCA, 60mg/kg) administration. Cholesterol, phospholipids and crystals in bile, the lipid in serum, pathological changes and proteins expression in liver were analyzed. The results showed that PA could decrease the cholesterol potency and crystals in bile, reduce total cholesterol (TC), triglycerides (TG) and increase high-density lipoprotein/low-density lipoprotein (HDL/LDL) levels in serum. Furthermore, PA treatment reduced liver lipid peroxidation and protected hepatobiliary cells from liver injury by decreasing malondialdehyde (MDA) and increasing superoxide dismutase (SOD). In addition, PA inhibited the expression of ATP-binding cassette transporters G5/8 (ABCG5/8) and liver X receptor (LXR) in liver, and reduced cholesterol transport from the hepatocytes to the gallbladder. It may be the mechanism of PA in preventing cholesterol gallstones formation. PA as a potential drug for prevention cholesterol gallstones merits further investigation.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2015.01.038</identifier><identifier>PMID: 25645812</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alkaloids - pharmacology ; Animals ; ATP Binding Cassette Transporter, Sub-Family G, Member 5 ; ATP Binding Cassette Transporter, Sub-Family G, Member 8 ; ATP-binding cassette transporters ; ATP-Binding Cassette Transporters - metabolism ; Benzodioxoles - pharmacology ; Bile - drug effects ; Bile - metabolism ; Biliary cholesterol ; Cholesterol - metabolism ; Cholesterol gallstones ; Diet - adverse effects ; Gallstones - etiology ; Gallstones - metabolism ; Gallstones - prevention & control ; Gene Expression Regulation - drug effects ; Lipid Peroxidation - drug effects ; Lipoproteins - metabolism ; Liver - drug effects ; Liver - injuries ; Liver - metabolism ; Liver - pathology ; Liver X receptor ; Liver X Receptors ; Male ; Mice ; Mice, Inbred C57BL ; Orphan Nuclear Receptors - metabolism ; Piperidines - pharmacology ; Piperine ; Polyunsaturated Alkamides - pharmacology</subject><ispartof>European journal of pharmacology, 2015-03, Vol.751, p.112-117</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-6158521cf797b7ac0f4a5f71c0939e61c68926fb13de2fabd3ffe0346367d6733</citedby><cites>FETCH-LOGICAL-c362t-6158521cf797b7ac0f4a5f71c0939e61c68926fb13de2fabd3ffe0346367d6733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2015.01.038$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25645812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Xiu-Yun</creatorcontrib><creatorcontrib>Xu, Shuang</creatorcontrib><creatorcontrib>Hu, Jin-Feng</creatorcontrib><creatorcontrib>Tang, Jia</creatorcontrib><creatorcontrib>Chu, Shi-Feng</creatorcontrib><creatorcontrib>Liu, Hang</creatorcontrib><creatorcontrib>Han, Ning</creatorcontrib><creatorcontrib>Li, Jing-Wei</creatorcontrib><creatorcontrib>Zhang, Dong-Ming</creatorcontrib><creatorcontrib>Li, Yue-Ting</creatorcontrib><creatorcontrib>Chen, Nai-Hong</creatorcontrib><title>Piperine prevents cholesterol gallstones formation in mice</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Biliary cholesterol may contribute to the formation of cholesterol gallstones, and regulation of these levels could be a useful therapeutic strategy for gallstones disease. Piperine (PA) is a potential cholesterol lowering agent. In this study, we assessed the effect and mechanism of PA in preventing cholesterol gallstones formation induced by feeding lithogenic diet containing high cholesterol levels to mice. C57BL/6 inbred mice were fed lithogenic or chow diets for 10 weeks, with or without PA (15, 30 and 60mg/kg) or ursodeoxycholic acid (UDCA, 60mg/kg) administration. Cholesterol, phospholipids and crystals in bile, the lipid in serum, pathological changes and proteins expression in liver were analyzed. The results showed that PA could decrease the cholesterol potency and crystals in bile, reduce total cholesterol (TC), triglycerides (TG) and increase high-density lipoprotein/low-density lipoprotein (HDL/LDL) levels in serum. Furthermore, PA treatment reduced liver lipid peroxidation and protected hepatobiliary cells from liver injury by decreasing malondialdehyde (MDA) and increasing superoxide dismutase (SOD). In addition, PA inhibited the expression of ATP-binding cassette transporters G5/8 (ABCG5/8) and liver X receptor (LXR) in liver, and reduced cholesterol transport from the hepatocytes to the gallbladder. It may be the mechanism of PA in preventing cholesterol gallstones formation. PA as a potential drug for prevention cholesterol gallstones merits further investigation.</description><subject>Alkaloids - pharmacology</subject><subject>Animals</subject><subject>ATP Binding Cassette Transporter, Sub-Family G, Member 5</subject><subject>ATP Binding Cassette Transporter, Sub-Family G, Member 8</subject><subject>ATP-binding cassette transporters</subject><subject>ATP-Binding Cassette Transporters - metabolism</subject><subject>Benzodioxoles - pharmacology</subject><subject>Bile - drug effects</subject><subject>Bile - metabolism</subject><subject>Biliary cholesterol</subject><subject>Cholesterol - metabolism</subject><subject>Cholesterol gallstones</subject><subject>Diet - adverse effects</subject><subject>Gallstones - etiology</subject><subject>Gallstones - metabolism</subject><subject>Gallstones - prevention & control</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipoproteins - metabolism</subject><subject>Liver - drug effects</subject><subject>Liver - injuries</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver X receptor</subject><subject>Liver X Receptors</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Orphan Nuclear Receptors - metabolism</subject><subject>Piperidines - pharmacology</subject><subject>Piperine</subject><subject>Polyunsaturated Alkamides - pharmacology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78A5EevbTOJG3aeBBE_AJBD3oO2XSiWdqmJl3Bf29l1aOnuTzvvDMPY8cIBQLKs1VBq_HNxIIDVgVgAaLZYgtsapVDjXybLQCwzLlSao_tp7QCgErxapft8UqWVYN8wc6f_EjRD5SNkT5omFJm30JHaaIYuuzVdF2awkApcyH2ZvJhyPyQ9d7SIdtxpkt09DMP2MvN9fPVXf7weHt_dfmQWyH5lEusmoqjdbWql7Wx4EpTuRotKKFIopWN4tItUbTEnVm2wjkCUUoh61bWQhyw083eMYb39XyZ7n2y1HVmoLBOGqXkMAe4nNFyg9oYUork9Bh9b-KnRtDf1vRKb6zpb2saUM_W5tjJT8N62VP7F_rVNAMXG4DmPz88RZ2sp8FS6yPZSbfB_9_wBdYef4Y</recordid><startdate>20150315</startdate><enddate>20150315</enddate><creator>Song, Xiu-Yun</creator><creator>Xu, Shuang</creator><creator>Hu, Jin-Feng</creator><creator>Tang, Jia</creator><creator>Chu, Shi-Feng</creator><creator>Liu, Hang</creator><creator>Han, Ning</creator><creator>Li, Jing-Wei</creator><creator>Zhang, Dong-Ming</creator><creator>Li, Yue-Ting</creator><creator>Chen, Nai-Hong</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150315</creationdate><title>Piperine prevents cholesterol gallstones formation in mice</title><author>Song, Xiu-Yun ; Xu, Shuang ; Hu, Jin-Feng ; Tang, Jia ; Chu, Shi-Feng ; Liu, Hang ; Han, Ning ; Li, Jing-Wei ; Zhang, Dong-Ming ; Li, Yue-Ting ; Chen, Nai-Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-6158521cf797b7ac0f4a5f71c0939e61c68926fb13de2fabd3ffe0346367d6733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alkaloids - pharmacology</topic><topic>Animals</topic><topic>ATP Binding Cassette Transporter, Sub-Family G, Member 5</topic><topic>ATP Binding Cassette Transporter, Sub-Family G, Member 8</topic><topic>ATP-binding cassette transporters</topic><topic>ATP-Binding Cassette Transporters - metabolism</topic><topic>Benzodioxoles - pharmacology</topic><topic>Bile - drug effects</topic><topic>Bile - metabolism</topic><topic>Biliary cholesterol</topic><topic>Cholesterol - metabolism</topic><topic>Cholesterol gallstones</topic><topic>Diet - adverse effects</topic><topic>Gallstones - etiology</topic><topic>Gallstones - metabolism</topic><topic>Gallstones - prevention & control</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipoproteins - metabolism</topic><topic>Liver - drug effects</topic><topic>Liver - injuries</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver X receptor</topic><topic>Liver X Receptors</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Orphan Nuclear Receptors - metabolism</topic><topic>Piperidines - pharmacology</topic><topic>Piperine</topic><topic>Polyunsaturated Alkamides - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Xiu-Yun</creatorcontrib><creatorcontrib>Xu, Shuang</creatorcontrib><creatorcontrib>Hu, Jin-Feng</creatorcontrib><creatorcontrib>Tang, Jia</creatorcontrib><creatorcontrib>Chu, Shi-Feng</creatorcontrib><creatorcontrib>Liu, Hang</creatorcontrib><creatorcontrib>Han, Ning</creatorcontrib><creatorcontrib>Li, Jing-Wei</creatorcontrib><creatorcontrib>Zhang, Dong-Ming</creatorcontrib><creatorcontrib>Li, Yue-Ting</creatorcontrib><creatorcontrib>Chen, Nai-Hong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Xiu-Yun</au><au>Xu, Shuang</au><au>Hu, Jin-Feng</au><au>Tang, Jia</au><au>Chu, Shi-Feng</au><au>Liu, Hang</au><au>Han, Ning</au><au>Li, Jing-Wei</au><au>Zhang, Dong-Ming</au><au>Li, Yue-Ting</au><au>Chen, Nai-Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Piperine prevents cholesterol gallstones formation in mice</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2015-03-15</date><risdate>2015</risdate><volume>751</volume><spage>112</spage><epage>117</epage><pages>112-117</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Biliary cholesterol may contribute to the formation of cholesterol gallstones, and regulation of these levels could be a useful therapeutic strategy for gallstones disease. Piperine (PA) is a potential cholesterol lowering agent. In this study, we assessed the effect and mechanism of PA in preventing cholesterol gallstones formation induced by feeding lithogenic diet containing high cholesterol levels to mice. C57BL/6 inbred mice were fed lithogenic or chow diets for 10 weeks, with or without PA (15, 30 and 60mg/kg) or ursodeoxycholic acid (UDCA, 60mg/kg) administration. Cholesterol, phospholipids and crystals in bile, the lipid in serum, pathological changes and proteins expression in liver were analyzed. The results showed that PA could decrease the cholesterol potency and crystals in bile, reduce total cholesterol (TC), triglycerides (TG) and increase high-density lipoprotein/low-density lipoprotein (HDL/LDL) levels in serum. Furthermore, PA treatment reduced liver lipid peroxidation and protected hepatobiliary cells from liver injury by decreasing malondialdehyde (MDA) and increasing superoxide dismutase (SOD). In addition, PA inhibited the expression of ATP-binding cassette transporters G5/8 (ABCG5/8) and liver X receptor (LXR) in liver, and reduced cholesterol transport from the hepatocytes to the gallbladder. It may be the mechanism of PA in preventing cholesterol gallstones formation. PA as a potential drug for prevention cholesterol gallstones merits further investigation.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25645812</pmid><doi>10.1016/j.ejphar.2015.01.038</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 2015-03, Vol.751, p.112-117 |
| issn | 0014-2999 1879-0712 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1662003426 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alkaloids - pharmacology Animals ATP Binding Cassette Transporter, Sub-Family G, Member 5 ATP Binding Cassette Transporter, Sub-Family G, Member 8 ATP-binding cassette transporters ATP-Binding Cassette Transporters - metabolism Benzodioxoles - pharmacology Bile - drug effects Bile - metabolism Biliary cholesterol Cholesterol - metabolism Cholesterol gallstones Diet - adverse effects Gallstones - etiology Gallstones - metabolism Gallstones - prevention & control Gene Expression Regulation - drug effects Lipid Peroxidation - drug effects Lipoproteins - metabolism Liver - drug effects Liver - injuries Liver - metabolism Liver - pathology Liver X receptor Liver X Receptors Male Mice Mice, Inbred C57BL Orphan Nuclear Receptors - metabolism Piperidines - pharmacology Piperine Polyunsaturated Alkamides - pharmacology |
| title | Piperine prevents cholesterol gallstones formation in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T07%3A35%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Piperine%20prevents%20cholesterol%20gallstones%20formation%20in%20mice&rft.jtitle=European%20journal%20of%20pharmacology&rft.au=Song,%20Xiu-Yun&rft.date=2015-03-15&rft.volume=751&rft.spage=112&rft.epage=117&rft.pages=112-117&rft.issn=0014-2999&rft.eissn=1879-0712&rft_id=info:doi/10.1016/j.ejphar.2015.01.038&rft_dat=%3Cproquest_cross%3E1662003426%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1662003426&rft_id=info:pmid/25645812&rft_els_id=S0014299915000710&rfr_iscdi=true |