Post-myocardial Infarct Inflammation and the Potential Role of Cell Therapy
Myocardial infarction triggers reparative inflammatory processes programmed to repair damaged tissue. However, often additional injury to the myocardium occurs through the course of this inflammatory process, which ultimately can lead to heart failure. The potential beneficial effects of cell therap...
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| Veröffentlicht in: | Cardiovascular drugs and therapy 2015-02, Vol.29 (1), p.59-73 |
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| container_title | Cardiovascular drugs and therapy |
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| creator | van Zuylen, Vanessa-leigh den Haan, Melina C. Geutskens, Sacha B. Roelofs, Helene Fibbe, Willem E. Schalij, Martin J. Atsma, Douwe E. |
| description | Myocardial infarction triggers reparative inflammatory processes programmed to repair damaged tissue. However, often additional injury to the myocardium occurs through the course of this inflammatory process, which ultimately can lead to heart failure. The potential beneficial effects of cell therapy in treating cardiac ischemic disease, the number one cause of death worldwide, are being studied extensively, both in clinical trials using adult stem cells as well as in fundamental research on cardiac stem cells and regenerative biology. This review summarizes the current knowledge on molecular and cellular processes implicated in post-infarction inflammation and discusses the potential beneficial role cell therapy might play in this process. Due to its immunomodulatory properties, the mesenchymal stromal cell is a candidate to reverse the disease progression of the infarcted heart towards heart failure, and therefore is emphasized in this review. |
| doi_str_mv | 10.1007/s10557-014-6568-z |
| format | Article |
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However, often additional injury to the myocardium occurs through the course of this inflammatory process, which ultimately can lead to heart failure. The potential beneficial effects of cell therapy in treating cardiac ischemic disease, the number one cause of death worldwide, are being studied extensively, both in clinical trials using adult stem cells as well as in fundamental research on cardiac stem cells and regenerative biology. This review summarizes the current knowledge on molecular and cellular processes implicated in post-infarction inflammation and discusses the potential beneficial role cell therapy might play in this process. 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| subjects | Animals Cardiology Cell- and Tissue-Based Therapy Humans Inflammation - immunology Inflammation - therapy Medicine Medicine & Public Health Myocardial Infarction - immunology Myocardial Infarction - therapy Reperfusion Injury - immunology Reperfusion Injury - therapy Review Article |
| title | Post-myocardial Infarct Inflammation and the Potential Role of Cell Therapy |
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