The effects of different adjuvants on intestinal antigen absorption and subsequent immune responses of the tilapian Oreochromis mossambicus
The effects of three potential adjuvants, cholera toxin β-subunit (CTB); aluminium hydroxide [Al(0H)3] and ammonium chloride (NH4Cl) on the absorption of human gamma globulin (HGG) from the gastrointestinal tract of the tilapian Oreochromis mossambicus, and subsequent antibody generation were invest...
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| Veröffentlicht in: | Fish & shellfish immunology 1994-05, Vol.4 (3), p.167-177 |
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| container_title | Fish & shellfish immunology |
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| creator | Jenkins, P.G. Wrathmell, A.B. Harris, J.E. Pulsford, A.L. |
| description | The effects of three potential adjuvants, cholera toxin β-subunit (CTB); aluminium hydroxide [Al(0H)3] and ammonium chloride (NH4Cl) on the absorption of human gamma globulin (HGG) from the gastrointestinal tract of the tilapian Oreochromis mossambicus, and subsequent antibody generation were investigated utilising specific ELISA assays. CTB increased the levels of HGG transcytosed into the plasma over levels observed after HGG delivery alone or delivery of HGG with either Al(OH)3 or NH4Cl. The enteric immunisation with HGG plus CTB or Al(OH)3 resulted in antibody titres that were raised above those observed after the enteric immunisation with the antigen on its own or with NH4Cl. Parenteral immunisation with each of the three adjuvants resulted in levels of specific antibodies similar to those achieved after immunisation with HGG alone. |
| doi_str_mv | 10.1006/fsim.1994.1016 |
| format | Article |
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CTB increased the levels of HGG transcytosed into the plasma over levels observed after HGG delivery alone or delivery of HGG with either Al(OH)3 or NH4Cl. The enteric immunisation with HGG plus CTB or Al(OH)3 resulted in antibody titres that were raised above those observed after the enteric immunisation with the antigen on its own or with NH4Cl. Parenteral immunisation with each of the three adjuvants resulted in levels of specific antibodies similar to those achieved after immunisation with HGG alone.</description><identifier>ISSN: 1050-4648</identifier><identifier>EISSN: 1095-9947</identifier><identifier>DOI: 10.1006/fsim.1994.1016</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Freshwater ; oral immunisation, antigen, absorption, antibody response, HGG, cholera toxin, aluminium hydroxide, ammonium chloride, tilapia ; Oreochromis mossambicus</subject><ispartof>Fish & shellfish immunology, 1994-05, Vol.4 (3), p.167-177</ispartof><rights>1994 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-13856f8d0cac0b6a42e9c311b9828baadeaa7dc15d7a6d300b7b12d9811e8be33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/fsim.1994.1016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids></links><search><creatorcontrib>Jenkins, P.G.</creatorcontrib><creatorcontrib>Wrathmell, A.B.</creatorcontrib><creatorcontrib>Harris, J.E.</creatorcontrib><creatorcontrib>Pulsford, A.L.</creatorcontrib><title>The effects of different adjuvants on intestinal antigen absorption and subsequent immune responses of the tilapian Oreochromis mossambicus</title><title>Fish & shellfish immunology</title><description>The effects of three potential adjuvants, cholera toxin β-subunit (CTB); aluminium hydroxide [Al(0H)3] and ammonium chloride (NH4Cl) on the absorption of human gamma globulin (HGG) from the gastrointestinal tract of the tilapian Oreochromis mossambicus, and subsequent antibody generation were investigated utilising specific ELISA assays. CTB increased the levels of HGG transcytosed into the plasma over levels observed after HGG delivery alone or delivery of HGG with either Al(OH)3 or NH4Cl. The enteric immunisation with HGG plus CTB or Al(OH)3 resulted in antibody titres that were raised above those observed after the enteric immunisation with the antigen on its own or with NH4Cl. Parenteral immunisation with each of the three adjuvants resulted in levels of specific antibodies similar to those achieved after immunisation with HGG alone.</description><subject>Freshwater</subject><subject>oral immunisation, antigen, absorption, antibody response, HGG, cholera toxin, aluminium hydroxide, ammonium chloride, tilapia</subject><subject>Oreochromis mossambicus</subject><issn>1050-4648</issn><issn>1095-9947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNp1kLtOxDAQRSMEEs-W2hVdFnuTdZISIV4SEg3U1tiesF4ldvA4SHwDP43D0lLN88xc3aK4FHwlOJfXPblxJbquzqWQB8WJ4N2mzHVzuOQbXtaybo-LU6Idz0Al-Unx_bpFhn2PJhELPbMu5xF9YmB38yf4pe2Z8wkpOQ8Dyy33jp6BphCn5PIUvGU0a8KPeSHdOM4eWUSagif8vZvym-QGmBx49hIxmG0MoyM2BiIYtTMznRdHPQyEF3_xrHi7v3u9fSyfXx6ebm-eS1OJJpWiajeyby03YLiWUK-xyxOhu3bdagCLAI01YmMbkLbiXDdarG3XCoGtxqo6K672d6cYsmJKKgsxOAzgMcykhJSiqyuZF1f7RROzyoi9mqIbIX4pwdXiuVo8V4vnavE8A-0ewCz_02FUZBx6g9bF7LCywf2H_gCk8Y1q</recordid><startdate>19940501</startdate><enddate>19940501</enddate><creator>Jenkins, P.G.</creator><creator>Wrathmell, A.B.</creator><creator>Harris, J.E.</creator><creator>Pulsford, A.L.</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>H98</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope></search><sort><creationdate>19940501</creationdate><title>The effects of different adjuvants on intestinal antigen absorption and subsequent immune responses of the tilapian Oreochromis mossambicus</title><author>Jenkins, P.G. ; Wrathmell, A.B. ; Harris, J.E. ; Pulsford, A.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-13856f8d0cac0b6a42e9c311b9828baadeaa7dc15d7a6d300b7b12d9811e8be33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Freshwater</topic><topic>oral immunisation, antigen, absorption, antibody response, HGG, cholera toxin, aluminium hydroxide, ammonium chloride, tilapia</topic><topic>Oreochromis mossambicus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jenkins, P.G.</creatorcontrib><creatorcontrib>Wrathmell, A.B.</creatorcontrib><creatorcontrib>Harris, J.E.</creatorcontrib><creatorcontrib>Pulsford, A.L.</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Fish & shellfish immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jenkins, P.G.</au><au>Wrathmell, A.B.</au><au>Harris, J.E.</au><au>Pulsford, A.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of different adjuvants on intestinal antigen absorption and subsequent immune responses of the tilapian Oreochromis mossambicus</atitle><jtitle>Fish & shellfish immunology</jtitle><date>1994-05-01</date><risdate>1994</risdate><volume>4</volume><issue>3</issue><spage>167</spage><epage>177</epage><pages>167-177</pages><issn>1050-4648</issn><eissn>1095-9947</eissn><abstract>The effects of three potential adjuvants, cholera toxin β-subunit (CTB); aluminium hydroxide [Al(0H)3] and ammonium chloride (NH4Cl) on the absorption of human gamma globulin (HGG) from the gastrointestinal tract of the tilapian Oreochromis mossambicus, and subsequent antibody generation were investigated utilising specific ELISA assays. CTB increased the levels of HGG transcytosed into the plasma over levels observed after HGG delivery alone or delivery of HGG with either Al(OH)3 or NH4Cl. The enteric immunisation with HGG plus CTB or Al(OH)3 resulted in antibody titres that were raised above those observed after the enteric immunisation with the antigen on its own or with NH4Cl. Parenteral immunisation with each of the three adjuvants resulted in levels of specific antibodies similar to those achieved after immunisation with HGG alone.</abstract><pub>Elsevier Ltd</pub><doi>10.1006/fsim.1994.1016</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1050-4648 |
| ispartof | Fish & shellfish immunology, 1994-05, Vol.4 (3), p.167-177 |
| issn | 1050-4648 1095-9947 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16619436 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Freshwater oral immunisation, antigen, absorption, antibody response, HGG, cholera toxin, aluminium hydroxide, ammonium chloride, tilapia Oreochromis mossambicus |
| title | The effects of different adjuvants on intestinal antigen absorption and subsequent immune responses of the tilapian Oreochromis mossambicus |
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