Solution conformation of the (+)-cis-anti-[BP]dG adduct in a DNA duplex: Intercalation of the covalently attached benzo[a]pyrenyl ring into the helix and displacement of the modified deoxyguanosine

This paper reports on the solution structure of the (+)-cis-anti-[BP]dG adduct positioned opposite dC in a DNA oligomer duplex which provides the first experimentally based solution structure of an intercalative complex of a polycyclic aromatic hydrocarbon covalently bound to the N2 of deoxyguanosin...

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Veröffentlicht in:	Biochemistry (Easton) 1993-04, Vol.32 (16), p.4145-4155
Hauptverfasser:	Cosman, Monique, de los Santos, Carlos, Fiala, Radovan, Hingerty, Brian E, Ibanez, Victor, Luna, Ernestina, Harvey, Ronald, Geacintov, Nicholas E, Broyde, Suse, Patel, Dinshaw J
Format:	Artikel
Sprache:	eng
Schlagworte:	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - analogs & derivatives 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - chemistry Analytical, structural and metabolic biochemistry Base Composition Base Sequence Benzo(a)pyrene - chemistry Biological and medical sciences Deoxyguanosine - analogs & derivatives Deoxyguanosine - chemistry DNA - chemistry Dna, deoxyribonucleoproteins Fundamental and applied biological sciences. Psychology Hydrogen Bonding Intercalating Agents Magnetic Resonance Spectroscopy - methods Models, Molecular Molecular Conformation Molecular Sequence Data Nucleic Acid Conformation Nucleic acids Oligodeoxyribonucleotides - chemistry Solutions Thermodynamics
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