Chronic MPTP treatment reproduces in baboons the differential vulnerability of mesencephalic dopaminergic neurons observed in parkinson's disease

Chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to baboons was shown previously to result in a motor syndrome and a pattern of striatal dopaminergic fibre loss similar to those observed in idiopathic Parkinson's disease. In the present study, tyrosine hydroxylase-i...

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Veröffentlicht in:	Neuroscience 1994-11, Vol.63 (1), p.47-56
Hauptverfasser:	Varastet, M., Riche, D., Maziere, M., Hantraye, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine - physiology Immunohistochemistry Medical sciences Mesencephalon - enzymology Mesencephalon - metabolism Mesencephalon - pathology MPTP Poisoning Neurology Neurons - drug effects Neurons - enzymology Neurons - metabolism Papio Papio papio Parkinson Disease - metabolism Parkinson Disease - pathology Substantia Nigra - metabolism Substantia Nigra - pathology Tyrosine 3-Monooxygenase - metabolism
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