Synthetic approach toward complexity of sialic acid-containing glycans
The biological relevance of sialic acid-containing glycans (sialo-glycans) to various interactions at the cell surface has increased the demand for the supply of structurally defined sialo-glycans. Due to their unique structures, the stereoselective synthesis of glycosides of sialic acid is inherent...
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| Veröffentlicht in: | Bioscience, Biotechnology, and Biochemistry Biotechnology, and Biochemistry, 2015-03, Vol.79 (3), p.343-346 |
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| creator | Ando, Hiromune |
| description | The biological relevance of sialic acid-containing glycans (sialo-glycans) to various interactions at the cell surface has increased the demand for the supply of structurally defined sialo-glycans. Due to their unique structures, the stereoselective synthesis of glycosides of sialic acid is inherently difficult, which makes the synthetic approach to synthesize diverse and complex sialo-glycans far from successful. However, the gap between the chemical and natural synthesis of complex sialo-glycans is narrowing through the emergence of synthetic methods. This review highlights recent progress made in the synthesis of complex sialo-glycans via cutting-edge synthetic methods.
The development of versatile synthetic units of sialic acid allowed to synthesize highly complicated sialic acid-containing molecules. |
| doi_str_mv | 10.1080/09168451.2014.990228 |
| format | Article |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals |
| subjects | Chemistry Techniques, Synthetic - methods glycan Glycosylation Hydroxides - chemistry N-Acetylneuraminic Acid organic synthesis Polysaccharides - chemical synthesis Polysaccharides - chemistry sialic acid |
| title | Synthetic approach toward complexity of sialic acid-containing glycans |
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