Low-dose glimepiride with sitagliptin improves glycemic control without dose-dependency in patients with type 2 diabetes inadequately controlled on high-dose glimepiride

This randomized, prospective study was conducted in 76 subjects to assess whether low-dose (0.5-2 mg/day) glimepiride, in combination therapy with sitagliptin, improves glycemic control in a dose-dependent manner in Japanese patients with type 2 diabetes. Eligible subjects had been treated with glim...

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Veröffentlicht in:	Endocrine Journal 2014, Vol.61(12), pp.1163-1170
Hauptverfasser:	Umayahara, Rieko, Yonemoto, Takako, Kyou, Chika, Morishita, Kae, Ogawa, Tatsuo, Taguchi, Yoshitaka, Inoue, Tatsuhide
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Cohort Studies Combination therapy Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - ethnology Diabetic Nephropathies - physiopathology Dipeptidyl-Peptidase IV Inhibitors - administration & dosage Dipeptidyl-Peptidase IV Inhibitors - adverse effects Dipeptidyl-Peptidase IV Inhibitors - therapeutic use Dose-dependency Dose-Response Relationship, Drug Drug Resistance Drug Therapy, Combination - adverse effects Female Glycated Hemoglobin A - analysis Glycemic control Humans Hyperglycemia - prevention & control Incretins - administration & dosage Incretins - adverse effects Incretins - therapeutic use Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Japan Kidney - physiopathology Low-dose glimepiride Male Middle Aged Pyrazines - administration & dosage Pyrazines - adverse effects Pyrazines - therapeutic use Severity of Illness Index Sitagliptin Sitagliptin Phosphate Sulfonylurea Compounds - administration & dosage Sulfonylurea Compounds - adverse effects Sulfonylurea Compounds - therapeutic use Triazoles - administration & dosage Triazoles - adverse effects Triazoles - therapeutic use
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