TFE3 Is a bHLH-ZIP-type Transcription Factor that Regulates the Mammalian Golgi Stress Response
The Golgi stress response is a mechanism by which, under conditions of insufficient Golgi function (Golgi stress), the transcription of Golgi-related genes is upregulated through an enhancer, the Golgi apparatus stress response element (GASE), in order to maintain homeostasis in the Golgi. The molec...
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| Veröffentlicht in: | Cell Structure and Function 2015, Vol.40(1), pp.13-30 |
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| container_title | Cell Structure and Function |
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| creator | Taniguchi, Mai Nadanaka, Satomi Tanakura, Soichiro Sawaguchi, Shogo Midori, Sachiko Kawai, Yumeto Yamaguchi, Shogo Shimada, Yui Nakamura, Yuki Matsumura, Yasuyo Fujita, Natsumi Araki, Naoko Yamamoto, Mayu Oku, Masaya Wakabayashi, Sadao Kitagawa, Hiroshi Yoshida, Hiderou |
| description | The Golgi stress response is a mechanism by which, under conditions of insufficient Golgi function (Golgi stress), the transcription of Golgi-related genes is upregulated through an enhancer, the Golgi apparatus stress response element (GASE), in order to maintain homeostasis in the Golgi. The molecular mechanisms associated with GASE remain to be clarified. Here, we identified TFE3 as a GASE-binding transcription factor. TFE3 was phosphorylated and retained in the cytoplasm in normal growth conditions, whereas it was dephosphorylated, translocated to the nucleus and activated Golgi-related genes through GASE under conditions of Golgi stress, e.g. in response to inhibition of oligosaccharide processing in the Golgi apparatus. From these observations, we concluded that the TFE3-GASE pathway is one of the regulatory pathways of the mammalian Golgi stress response, which regulates the expression of glycosylation-related proteins in response to insufficiency of glycosylation in the Golgi apparatus. |
| doi_str_mv | 10.1247/csf.14015 |
| format | Article |
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The molecular mechanisms associated with GASE remain to be clarified. Here, we identified TFE3 as a GASE-binding transcription factor. TFE3 was phosphorylated and retained in the cytoplasm in normal growth conditions, whereas it was dephosphorylated, translocated to the nucleus and activated Golgi-related genes through GASE under conditions of Golgi stress, e.g. in response to inhibition of oligosaccharide processing in the Golgi apparatus. From these observations, we concluded that the TFE3-GASE pathway is one of the regulatory pathways of the mammalian Golgi stress response, which regulates the expression of glycosylation-related proteins in response to insufficiency of glycosylation in the Golgi apparatus.</description><identifier>ISSN: 0386-7196</identifier><identifier>EISSN: 1347-3700</identifier><identifier>DOI: 10.1247/csf.14015</identifier><identifier>PMID: 25399611</identifier><language>eng</language><publisher>Japan: Japan Society for Cell Biology</publisher><subject>Active Transport, Cell Nucleus ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism ; Cell Nucleus - metabolism ; ER stress ; Glycosylation ; Golgi Apparatus - genetics ; Golgi Apparatus - metabolism ; Golgi stress ; HeLa Cells ; Humans ; Lipid Metabolism ; Oxidative Stress - genetics ; Phosphorylation ; proteoglycan ; Proteoglycans - metabolism ; Response Elements ; sialyltransferase ; Transcription, Genetic ; Transcriptional Activation</subject><ispartof>Cell Structure and Function, 2015, Vol.40(1), pp.13-30</ispartof><rights>2015 by Japan Society for Cell Biology</rights><rights>Copyright Japan Science and Technology Agency 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-2a6a192817251907531d7a9e80f8ba4a0d33f05b374a402d3504c391290ab3e33</citedby><cites>FETCH-LOGICAL-c494t-2a6a192817251907531d7a9e80f8ba4a0d33f05b374a402d3504c391290ab3e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25399611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taniguchi, Mai</creatorcontrib><creatorcontrib>Nadanaka, Satomi</creatorcontrib><creatorcontrib>Tanakura, Soichiro</creatorcontrib><creatorcontrib>Sawaguchi, Shogo</creatorcontrib><creatorcontrib>Midori, Sachiko</creatorcontrib><creatorcontrib>Kawai, Yumeto</creatorcontrib><creatorcontrib>Yamaguchi, Shogo</creatorcontrib><creatorcontrib>Shimada, Yui</creatorcontrib><creatorcontrib>Nakamura, Yuki</creatorcontrib><creatorcontrib>Matsumura, Yasuyo</creatorcontrib><creatorcontrib>Fujita, Natsumi</creatorcontrib><creatorcontrib>Araki, Naoko</creatorcontrib><creatorcontrib>Yamamoto, Mayu</creatorcontrib><creatorcontrib>Oku, Masaya</creatorcontrib><creatorcontrib>Wakabayashi, Sadao</creatorcontrib><creatorcontrib>Kitagawa, Hiroshi</creatorcontrib><creatorcontrib>Yoshida, Hiderou</creatorcontrib><title>TFE3 Is a bHLH-ZIP-type Transcription Factor that Regulates the Mammalian Golgi Stress Response</title><title>Cell Structure and Function</title><addtitle>Cell Struct. Funct.</addtitle><description>The Golgi stress response is a mechanism by which, under conditions of insufficient Golgi function (Golgi stress), the transcription of Golgi-related genes is upregulated through an enhancer, the Golgi apparatus stress response element (GASE), in order to maintain homeostasis in the Golgi. The molecular mechanisms associated with GASE remain to be clarified. Here, we identified TFE3 as a GASE-binding transcription factor. TFE3 was phosphorylated and retained in the cytoplasm in normal growth conditions, whereas it was dephosphorylated, translocated to the nucleus and activated Golgi-related genes through GASE under conditions of Golgi stress, e.g. in response to inhibition of oligosaccharide processing in the Golgi apparatus. From these observations, we concluded that the TFE3-GASE pathway is one of the regulatory pathways of the mammalian Golgi stress response, which regulates the expression of glycosylation-related proteins in response to insufficiency of glycosylation in the Golgi apparatus.</description><subject>Active Transport, Cell Nucleus</subject><subject>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism</subject><subject>Cell Nucleus - metabolism</subject><subject>ER stress</subject><subject>Glycosylation</subject><subject>Golgi Apparatus - genetics</subject><subject>Golgi Apparatus - metabolism</subject><subject>Golgi stress</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Lipid Metabolism</subject><subject>Oxidative Stress - genetics</subject><subject>Phosphorylation</subject><subject>proteoglycan</subject><subject>Proteoglycans - metabolism</subject><subject>Response Elements</subject><subject>sialyltransferase</subject><subject>Transcription, Genetic</subject><subject>Transcriptional Activation</subject><issn>0386-7196</issn><issn>1347-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0MtOGzEUBmALgUqgXfACyBKbdjFwfBk7XqEKERIpCETTTTfWmYknTDQ3bM-Ct69JgErd2LL86T9HPyFnDC4Zl_qqDNUlk8DyAzJhQupMaIBDMgExVZlmRh2TkxC2ADwHpb-QY54LYxRjE2JXs1tBF4EiLebLefZn8ZjF18HRlcculL4eYt13dIZl7D2Nzxjpk9uMDUYX0tPRe2xbbGrs6F3fbGr6K3oXQkJh6LvgvpKjCpvgvr3fp-T37HZ1M8-WD3eLm5_LrJRGxoyjQmb4lGmeMwM6F2yt0bgpVNMCJcJaiAryQmiJEvha5CBLYRg3gIVwQpyS7_vcwfcvowvRtnUoXdNg5_oxWKYUEwK0Mole_Ee3_ei7tJ1labDhwLVK6sdelb4PwbvKDr5u0b9aBvatdZtat7vWkz1_TxyL1q0_5UfNCVzvwTZE3LhPgD7WZeN2UTLF7o63yH8_z-it68RfSquQaA</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Taniguchi, Mai</creator><creator>Nadanaka, Satomi</creator><creator>Tanakura, Soichiro</creator><creator>Sawaguchi, Shogo</creator><creator>Midori, Sachiko</creator><creator>Kawai, Yumeto</creator><creator>Yamaguchi, Shogo</creator><creator>Shimada, Yui</creator><creator>Nakamura, Yuki</creator><creator>Matsumura, Yasuyo</creator><creator>Fujita, Natsumi</creator><creator>Araki, Naoko</creator><creator>Yamamoto, Mayu</creator><creator>Oku, Masaya</creator><creator>Wakabayashi, Sadao</creator><creator>Kitagawa, Hiroshi</creator><creator>Yoshida, Hiderou</creator><general>Japan Society for Cell Biology</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>TFE3 Is a bHLH-ZIP-type Transcription Factor that Regulates the Mammalian Golgi Stress Response</title><author>Taniguchi, Mai ; 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| ispartof | Cell Structure and Function, 2015, Vol.40(1), pp.13-30 |
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| subjects | Active Transport, Cell Nucleus Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Cell Nucleus - metabolism ER stress Glycosylation Golgi Apparatus - genetics Golgi Apparatus - metabolism Golgi stress HeLa Cells Humans Lipid Metabolism Oxidative Stress - genetics Phosphorylation proteoglycan Proteoglycans - metabolism Response Elements sialyltransferase Transcription, Genetic Transcriptional Activation |
| title | TFE3 Is a bHLH-ZIP-type Transcription Factor that Regulates the Mammalian Golgi Stress Response |
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