Use of MRI signal intensity of extraocular muscles to evaluate methylprednisolone pulse therapy in thyroid-associated ophthalmopathy
Purpose To quantitatively evaluate the efficacy of methylprednisolone pulse therapy for extraocular muscle inflammation in thyroid-associated ophthalmopathy (TAO) using the short-tau inversion-recovery (STIR) technique of magnetic resonance imaging (MRI). Methods The signal intensities of the superi...
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| Veröffentlicht in: | Japanese journal of ophthalmology 2015-03, Vol.59 (2), p.124-130 |
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| creator | Higashiyama, Tomoaki Nishida, Yasuhiro Morino, Katsutaro Ugi, Satoshi Nishio, Yoshihiko Maegawa, Hiroshi Ohji, Masahito |
| description | Purpose
To quantitatively evaluate the efficacy of methylprednisolone pulse therapy for extraocular muscle inflammation in thyroid-associated ophthalmopathy (TAO) using the short-tau inversion-recovery (STIR) technique of magnetic resonance imaging (MRI).
Methods
The signal intensities of the superior rectus (SR), inferior rectus (IR), lateral rectus (LR), medial rectus (MR), and superior oblique (SO) muscles were measured using the STIR images from 34 eyes of 17 patients with TAO before and after methylprednisolone pulse therapy and 19 eyes of 19 controls. The signal intensity ratio (SIR) of the signal intensity in muscles to that in brain white matter was calculated.
Results
The mean SIRs of the controls were 1.08 ± 0.26 in the SR, 1.32 ± 0.29 in the IR, 1.34 ± 0.19 in the LR, 1.47 ± 0.25 in the MR, and 1.28 ± 0.22 in the SO muscles. SIRs exceeding 2.0 were out of the normal range. The SIRs of the patients with TAO before treatment were 2.19 ± 0.64, 2.44 ± 0.58, 1.96 ± 0.43, 2.24 ± 0.47, and 1.91 ± 0.42, respectively, which was significantly (
P
|
| doi_str_mv | 10.1007/s10384-014-0365-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1661327419</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3614376041</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-364dc8ea4d4469535eb21d689bf16ad4354a66240e05e048f0a08c717aedd61a3</originalsourceid><addsrcrecordid>eNp1kdFrFDEQxoMo9tr6B_giAV98WTvJJrm9RylqC5WCtM9hbjPb25LdrElWbt_9w815VUTwYciQ-X3fwHyMvRbwXgCsL5KAulEViFK10dX-GVsJI-pKSmWesxWAFJUWWp-w05QeAUDJWr5kJ1Ir1SjTrNiP-0Q8dPzL12ue-ocRPe_HTGPq83L4p32OGNrZY-TDnFpPiefA6Tv6GTPxgfJu8VMkN_Yp-DASn2ZfPPOOIk5LcSvtEkPvKkwptH1ROR6mXd6hH8KEZXrOXnRYRK-e3jN2_-nj3eVVdXP7-fryw03VKiNzVRvl2oZQOaXMRteatlI402y2nTDoVK0VGiMVEGgC1XSA0LRrsUZyzgisz9i7o-8Uw7eZUrZDn1ryHkcKc7LClOPJtRKbgr79B30Mcyzn-UWBAQ2iLpQ4Um0MKUXq7BT7AeNiBdhDRPYYkS0R2UNEdl80b56c5-1A7o_idyYFkEcgldH4QPGv1f91_QlMqJ78</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1660605013</pqid></control><display><type>article</type><title>Use of MRI signal intensity of extraocular muscles to evaluate methylprednisolone pulse therapy in thyroid-associated ophthalmopathy</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Higashiyama, Tomoaki ; Nishida, Yasuhiro ; Morino, Katsutaro ; Ugi, Satoshi ; Nishio, Yoshihiko ; Maegawa, Hiroshi ; Ohji, Masahito</creator><creatorcontrib>Higashiyama, Tomoaki ; Nishida, Yasuhiro ; Morino, Katsutaro ; Ugi, Satoshi ; Nishio, Yoshihiko ; Maegawa, Hiroshi ; Ohji, Masahito</creatorcontrib><description>Purpose
To quantitatively evaluate the efficacy of methylprednisolone pulse therapy for extraocular muscle inflammation in thyroid-associated ophthalmopathy (TAO) using the short-tau inversion-recovery (STIR) technique of magnetic resonance imaging (MRI).
Methods
The signal intensities of the superior rectus (SR), inferior rectus (IR), lateral rectus (LR), medial rectus (MR), and superior oblique (SO) muscles were measured using the STIR images from 34 eyes of 17 patients with TAO before and after methylprednisolone pulse therapy and 19 eyes of 19 controls. The signal intensity ratio (SIR) of the signal intensity in muscles to that in brain white matter was calculated.
Results
The mean SIRs of the controls were 1.08 ± 0.26 in the SR, 1.32 ± 0.29 in the IR, 1.34 ± 0.19 in the LR, 1.47 ± 0.25 in the MR, and 1.28 ± 0.22 in the SO muscles. SIRs exceeding 2.0 were out of the normal range. The SIRs of the patients with TAO before treatment were 2.19 ± 0.64, 2.44 ± 0.58, 1.96 ± 0.43, 2.24 ± 0.47, and 1.91 ± 0.42, respectively, which was significantly (
P
< 0.001) higher than those of the controls; after treatment, the mean SIRs were 1.82 ± 0.57, 1.81 ± 0.49, 1.64 ± 0.35, 1.88 ± 0.43, and 1.54 ± 0.33, respectively, significantly (
P
< 0.001) lower in all muscles than those before treatment. However, the SIRs of some muscles remained over 2.0. Moreover, all cases that had deterioration of TAO had one or more muscles with a SIR exceeding 2.5 after treatment.
Conclusion
Extraocular muscle inflammation in TAO improved with treatment. However, inflammation in some muscles persisted after treatment, and a high SIR in the muscle after treatment suggested the risk of deterioration of TAO.</description><identifier>ISSN: 0021-5155</identifier><identifier>EISSN: 1613-2246</identifier><identifier>DOI: 10.1007/s10384-014-0365-x</identifier><identifier>PMID: 25448468</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Administration, Oral ; Adult ; Aged ; Clinical Investigation ; Diplopia - physiopathology ; Female ; Glucocorticoids - administration & dosage ; Graves Ophthalmopathy - drug therapy ; Graves Ophthalmopathy - physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Methylprednisolone - administration & dosage ; Middle Aged ; Oculomotor Muscles - pathology ; Ophthalmology ; Prednisolone - administration & dosage ; Pulse Therapy, Drug ; Young Adult</subject><ispartof>Japanese journal of ophthalmology, 2015-03, Vol.59 (2), p.124-130</ispartof><rights>Japanese Ophthalmological Society 2014</rights><rights>Japanese Ophthalmological Society 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-364dc8ea4d4469535eb21d689bf16ad4354a66240e05e048f0a08c717aedd61a3</citedby><cites>FETCH-LOGICAL-c462t-364dc8ea4d4469535eb21d689bf16ad4354a66240e05e048f0a08c717aedd61a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10384-014-0365-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10384-014-0365-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25448468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Higashiyama, Tomoaki</creatorcontrib><creatorcontrib>Nishida, Yasuhiro</creatorcontrib><creatorcontrib>Morino, Katsutaro</creatorcontrib><creatorcontrib>Ugi, Satoshi</creatorcontrib><creatorcontrib>Nishio, Yoshihiko</creatorcontrib><creatorcontrib>Maegawa, Hiroshi</creatorcontrib><creatorcontrib>Ohji, Masahito</creatorcontrib><title>Use of MRI signal intensity of extraocular muscles to evaluate methylprednisolone pulse therapy in thyroid-associated ophthalmopathy</title><title>Japanese journal of ophthalmology</title><addtitle>Jpn J Ophthalmol</addtitle><addtitle>Jpn J Ophthalmol</addtitle><description>Purpose
To quantitatively evaluate the efficacy of methylprednisolone pulse therapy for extraocular muscle inflammation in thyroid-associated ophthalmopathy (TAO) using the short-tau inversion-recovery (STIR) technique of magnetic resonance imaging (MRI).
Methods
The signal intensities of the superior rectus (SR), inferior rectus (IR), lateral rectus (LR), medial rectus (MR), and superior oblique (SO) muscles were measured using the STIR images from 34 eyes of 17 patients with TAO before and after methylprednisolone pulse therapy and 19 eyes of 19 controls. The signal intensity ratio (SIR) of the signal intensity in muscles to that in brain white matter was calculated.
Results
The mean SIRs of the controls were 1.08 ± 0.26 in the SR, 1.32 ± 0.29 in the IR, 1.34 ± 0.19 in the LR, 1.47 ± 0.25 in the MR, and 1.28 ± 0.22 in the SO muscles. SIRs exceeding 2.0 were out of the normal range. The SIRs of the patients with TAO before treatment were 2.19 ± 0.64, 2.44 ± 0.58, 1.96 ± 0.43, 2.24 ± 0.47, and 1.91 ± 0.42, respectively, which was significantly (
P
< 0.001) higher than those of the controls; after treatment, the mean SIRs were 1.82 ± 0.57, 1.81 ± 0.49, 1.64 ± 0.35, 1.88 ± 0.43, and 1.54 ± 0.33, respectively, significantly (
P
< 0.001) lower in all muscles than those before treatment. However, the SIRs of some muscles remained over 2.0. Moreover, all cases that had deterioration of TAO had one or more muscles with a SIR exceeding 2.5 after treatment.
Conclusion
Extraocular muscle inflammation in TAO improved with treatment. However, inflammation in some muscles persisted after treatment, and a high SIR in the muscle after treatment suggested the risk of deterioration of TAO.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Clinical Investigation</subject><subject>Diplopia - physiopathology</subject><subject>Female</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Graves Ophthalmopathy - drug therapy</subject><subject>Graves Ophthalmopathy - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methylprednisolone - administration & dosage</subject><subject>Middle Aged</subject><subject>Oculomotor Muscles - pathology</subject><subject>Ophthalmology</subject><subject>Prednisolone - administration & dosage</subject><subject>Pulse Therapy, Drug</subject><subject>Young Adult</subject><issn>0021-5155</issn><issn>1613-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kdFrFDEQxoMo9tr6B_giAV98WTvJJrm9RylqC5WCtM9hbjPb25LdrElWbt_9w815VUTwYciQ-X3fwHyMvRbwXgCsL5KAulEViFK10dX-GVsJI-pKSmWesxWAFJUWWp-w05QeAUDJWr5kJ1Ir1SjTrNiP-0Q8dPzL12ue-ocRPe_HTGPq83L4p32OGNrZY-TDnFpPiefA6Tv6GTPxgfJu8VMkN_Yp-DASn2ZfPPOOIk5LcSvtEkPvKkwptH1ROR6mXd6hH8KEZXrOXnRYRK-e3jN2_-nj3eVVdXP7-fryw03VKiNzVRvl2oZQOaXMRteatlI402y2nTDoVK0VGiMVEGgC1XSA0LRrsUZyzgisz9i7o-8Uw7eZUrZDn1ryHkcKc7LClOPJtRKbgr79B30Mcyzn-UWBAQ2iLpQ4Um0MKUXq7BT7AeNiBdhDRPYYkS0R2UNEdl80b56c5-1A7o_idyYFkEcgldH4QPGv1f91_QlMqJ78</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Higashiyama, Tomoaki</creator><creator>Nishida, Yasuhiro</creator><creator>Morino, Katsutaro</creator><creator>Ugi, Satoshi</creator><creator>Nishio, Yoshihiko</creator><creator>Maegawa, Hiroshi</creator><creator>Ohji, Masahito</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>Use of MRI signal intensity of extraocular muscles to evaluate methylprednisolone pulse therapy in thyroid-associated ophthalmopathy</title><author>Higashiyama, Tomoaki ; Nishida, Yasuhiro ; Morino, Katsutaro ; Ugi, Satoshi ; Nishio, Yoshihiko ; Maegawa, Hiroshi ; Ohji, Masahito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-364dc8ea4d4469535eb21d689bf16ad4354a66240e05e048f0a08c717aedd61a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Aged</topic><topic>Clinical Investigation</topic><topic>Diplopia - physiopathology</topic><topic>Female</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Graves Ophthalmopathy - drug therapy</topic><topic>Graves Ophthalmopathy - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methylprednisolone - administration & dosage</topic><topic>Middle Aged</topic><topic>Oculomotor Muscles - pathology</topic><topic>Ophthalmology</topic><topic>Prednisolone - administration & dosage</topic><topic>Pulse Therapy, Drug</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Higashiyama, Tomoaki</creatorcontrib><creatorcontrib>Nishida, Yasuhiro</creatorcontrib><creatorcontrib>Morino, Katsutaro</creatorcontrib><creatorcontrib>Ugi, Satoshi</creatorcontrib><creatorcontrib>Nishio, Yoshihiko</creatorcontrib><creatorcontrib>Maegawa, Hiroshi</creatorcontrib><creatorcontrib>Ohji, Masahito</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Higashiyama, Tomoaki</au><au>Nishida, Yasuhiro</au><au>Morino, Katsutaro</au><au>Ugi, Satoshi</au><au>Nishio, Yoshihiko</au><au>Maegawa, Hiroshi</au><au>Ohji, Masahito</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of MRI signal intensity of extraocular muscles to evaluate methylprednisolone pulse therapy in thyroid-associated ophthalmopathy</atitle><jtitle>Japanese journal of ophthalmology</jtitle><stitle>Jpn J Ophthalmol</stitle><addtitle>Jpn J Ophthalmol</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>59</volume><issue>2</issue><spage>124</spage><epage>130</epage><pages>124-130</pages><issn>0021-5155</issn><eissn>1613-2246</eissn><abstract>Purpose
To quantitatively evaluate the efficacy of methylprednisolone pulse therapy for extraocular muscle inflammation in thyroid-associated ophthalmopathy (TAO) using the short-tau inversion-recovery (STIR) technique of magnetic resonance imaging (MRI).
Methods
The signal intensities of the superior rectus (SR), inferior rectus (IR), lateral rectus (LR), medial rectus (MR), and superior oblique (SO) muscles were measured using the STIR images from 34 eyes of 17 patients with TAO before and after methylprednisolone pulse therapy and 19 eyes of 19 controls. The signal intensity ratio (SIR) of the signal intensity in muscles to that in brain white matter was calculated.
Results
The mean SIRs of the controls were 1.08 ± 0.26 in the SR, 1.32 ± 0.29 in the IR, 1.34 ± 0.19 in the LR, 1.47 ± 0.25 in the MR, and 1.28 ± 0.22 in the SO muscles. SIRs exceeding 2.0 were out of the normal range. The SIRs of the patients with TAO before treatment were 2.19 ± 0.64, 2.44 ± 0.58, 1.96 ± 0.43, 2.24 ± 0.47, and 1.91 ± 0.42, respectively, which was significantly (
P
< 0.001) higher than those of the controls; after treatment, the mean SIRs were 1.82 ± 0.57, 1.81 ± 0.49, 1.64 ± 0.35, 1.88 ± 0.43, and 1.54 ± 0.33, respectively, significantly (
P
< 0.001) lower in all muscles than those before treatment. However, the SIRs of some muscles remained over 2.0. Moreover, all cases that had deterioration of TAO had one or more muscles with a SIR exceeding 2.5 after treatment.
Conclusion
Extraocular muscle inflammation in TAO improved with treatment. However, inflammation in some muscles persisted after treatment, and a high SIR in the muscle after treatment suggested the risk of deterioration of TAO.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>25448468</pmid><doi>10.1007/s10384-014-0365-x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Japanese journal of ophthalmology, 2015-03, Vol.59 (2), p.124-130 |
| issn | 0021-5155 1613-2246 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Administration, Oral Adult Aged Clinical Investigation Diplopia - physiopathology Female Glucocorticoids - administration & dosage Graves Ophthalmopathy - drug therapy Graves Ophthalmopathy - physiopathology Humans Magnetic Resonance Imaging Male Medicine Medicine & Public Health Methylprednisolone - administration & dosage Middle Aged Oculomotor Muscles - pathology Ophthalmology Prednisolone - administration & dosage Pulse Therapy, Drug Young Adult |
| title | Use of MRI signal intensity of extraocular muscles to evaluate methylprednisolone pulse therapy in thyroid-associated ophthalmopathy |
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