Supply-Demand Mismatch Transients in Susceptible Peri-infarct Hot Zones Explain the Origins of Spreading Injury Depolarizations

Peri-infarct depolarizations (PIDs) are seemingly spontaneous spreading depression-like waves that negatively impact tissue outcome in both experimental and human stroke. Factors triggering PIDs are unknown. Here, we show that somatosensory activation of peri-infarct cortex triggers PIDs when the ac...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2015-03, Vol.85 (5), p.1117-1131
Hauptverfasser:	von Bornstädt, Daniel, Houben, Thijs, Seidel, Jessica L., Zheng, Yi, Dilekoz, Ergin, Qin, Tao, Sandow, Nora, Kura, Sreekanth, Eikermann-Haerter, Katharina, Endres, Matthias, Boas, David A., Moskowitz, Michael A., Lo, Eng H., Dreier, Jens P., Woitzik, Johannes, Sakadžić, Sava, Ayata, Cenk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Cerebral Infarction - metabolism Cerebral Infarction - pathology Cortical Spreading Depression - physiology Female Humans Infarction, Middle Cerebral Artery - metabolism Infarction, Middle Cerebral Artery - pathology Lasers Male Metabolism Mice Mice, Inbred C57BL Middle Aged Patients Somatosensory Cortex - metabolism Somatosensory Cortex - pathology Statistical analysis Statistical methods Stroke
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