First use of investigational antiviral drug pocapavir (v-073) for treating neonatal enteroviral sepsis
Neonatal enteroviral sepsis is a potentially fatal condition. Perinatally acquired infection and severe coagulopathy can be associated with a poor clinical outcome, and antiviral therapy is currently unavailable. Pocapavir (V-073) is an investigational drug candidate being developed for poliovirus i...
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| Veröffentlicht in: | The Pediatric infectious disease journal 2015-01, Vol.34 (1), p.52-54 |
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| container_end_page | 54 |
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| container_issue | 1 |
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| container_title | The Pediatric infectious disease journal |
| container_volume | 34 |
| creator | Torres-Torres, Sanet Myers, Angela L Klatte, J Michael Rhoden, Eric E Oberste, M Steven Collett, Marc S McCulloh, Russell J |
| description | Neonatal enteroviral sepsis is a potentially fatal condition. Perinatally acquired infection and severe coagulopathy can be associated with a poor clinical outcome, and antiviral therapy is currently unavailable. Pocapavir (V-073) is an investigational drug candidate being developed for poliovirus indications, but also has variable antiviral activity against nonpolio enteroviruses. We describe the first use of pocapavir in treating a case of severe neonatal enteroviral sepsis due to Coxsackievirus B3. |
| doi_str_mv | 10.1097/INF.0000000000000497 |
| format | Article |
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| ispartof | The Pediatric infectious disease journal, 2015-01, Vol.34 (1), p.52-54 |
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| language | eng |
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| source | Journals@Ovid Complete - AutoHoldings; MEDLINE |
| subjects | Antiviral Agents - therapeutic use Enterovirus B, Human - isolation & purification Enterovirus Infections - drug therapy Enterovirus Infections - virology Female Humans Infant, Newborn Poliovirus Sepsis - drug therapy Sepsis - virology Treatment Outcome |
| title | First use of investigational antiviral drug pocapavir (v-073) for treating neonatal enteroviral sepsis |
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